Neurotrophins and lung disease

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

Respiratory Syncytial Virus Bronchiolitis in Infancy Is an Important Risk Factor for Asthma and Allergy at Age 7

2000 • 1,123 citations

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1994 • 1,065 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

1994 • 978 citations

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1992 • 960 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo

1951 • 947 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

THE NERVE GROWTH FACTOR: PURIFICATION AS A 30,000-MOLECULAR-WEIGHT PROTEIN

1969 • 920 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Functional Interactions of Neurotrophins and Neurotrophin Receptors

1995 • 825 citations

Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

1994 • 804 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

1990 • 700 citations

PURIFICATION OF A NERVE-GROWTH PROMOTING PROTEIN FROM THE MOUSE SALIVARY GLAND AND ITS NEURO-CYTOTOXIC ANTISERUM

1960 • 692 citations

Neurotrophin signaling through the p75 neurotrophin receptor

2002 • 686 citations

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1993 • 670 citations

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

1992 • 633 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

1994 • 620 citations

Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo

1992 • 603 citations

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

1998 • 577 citations

Human β-nerve growth factor gene sequence highly homologous to that of mouse

1983 • 486 citations

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1992 • 480 citations

Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor.

1992 • 458 citations

Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma.

1996 • 423 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Nerve Growth Factor from Mouse Submaxillary Gland: Amino Acid Sequence

1971 • 401 citations

Nerve Growth Factor Is an Autocrine Survival Factor for Memory B Lymphocytes

1996 • 398 citations

Mast cells increase in tissues of neonatal rats injected with the nerve growth factor

1977 • 357 citations

Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones.

1993 • 315 citations

Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

1994 • 291 citations

Neurotrophins Are Increased in Bronchoalveolar Lavage Fluid after Segmental Allergen Provocation

1998 • 257 citations

Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma

1998 • 251 citations

Mediator release from mast cells by nerve growth factor. Neurotrophin specificity and receptor mediation

1993 • 239 citations

Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair

2001 • 236 citations

Nerve Growth Factor-Dependent Activation of NF-κB Contributes to Survival of Sympathetic Neurons

1998 • 225 citations

Neuropeptide expression in cultures of adult sensory neurons: Modulation of substance P and calcitonin gene-related peptide levels by nerve growth factor

1989 • 221 citations

Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors

1997 • 220 citations

Cutting Edge: Clonally Restricted Production of the Neurotrophins Brain-Derived Neurotrophic Factor and Neurotrophin-3 mRNA by Human Immune Cells and Th1/Th2-Polarized Expression of Their Receptors

1999 • 211 citations

Hyperinnervation of the Airways in Transgenic Mice Overexpressing Nerve Growth Factor

1998 • 210 citations

The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor.

1992 • 198 citations

p75-Mediated NF-κB Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor

1999 • 193 citations

Expression of functional trk protooncogene in human monocytes.

1993 • 185 citations

Acute Sensitization by NGF of the Response of Small-Diameter Sensory Neurons to Capsaicin

2001 • 165 citations

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1993 • 164 citations

Effects of nerve growth factor on rat peritoneal mast cells. Survival promotion and immediate-early gene induction.

1994 • 153 citations

Neurotrophins and Neurotrophin Receptors in Human Lung Cancer

2001 • 153 citations

Nerve growth factor functions as a chemoattractant for mast cells through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways

2000 • 145 citations

Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo

1988 • 142 citations

Nerve Growth Factor Induces a Neurokinin-1 Receptor– Mediated Airway Hyperresponsiveness in Guinea Pigs

1999 • 140 citations

Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs

2002 • 128 citations

Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains

1992 • 123 citations

Functional nerve growth factor receptors on human B lymphocytes. Interaction with IL-2.

1992 • 115 citations

Nerve growth factor levels and localisation in human asthmatic bronchi

2002 • 112 citations

Local increase in the number of mast cells and expression of nerve growth factor in the bronchus of asthmatic patients after repeated inhalation of allergen at low‐dose

2001 • 111 citations

Augmentation of Allergic Early-Phase Reaction by Nerve Growth Factor

2002 • 106 citations

Expression of trKB neurotrophin receptor during T cell development. Role of brain derived neurotrophic factor in immature thymocyte survival.

1996 • 91 citations

Rapid Phosphorylation of Phospholipase Cγ 1 by Brain‐Derived Neurotrophic Factor and Neurotrophin‐3 in Cultures of Embryonic Rat Cortical Neurons

1993 • 83 citations

The Low-Affinity Neurotrophin Receptor p75 Regulates the Function But Not the Selective Survival of Specific Subpopulations of Sensory Neurons

1997 • 81 citations

Expression of functional trk tyrosine kinase receptors after T cell activation.

1994 • 72 citations

Ligand activation of nerve growth factor receptor TrkA protects monocytes from apoptosis

2000 • 71 citations

Nerve growth factor signal transduction in human B lymphocytes is mediated by gp140trk

1996 • 70 citations

Nerve Growth Factor Induces Airway Hyperresponsiveness in Mice

2001 • 66 citations

Immunohistochemical analysis of TrkA neurotrophin receptor expression in human non‐neuronal carcinomas

1998 • 50 citations

Nerve growth factor stimulates fibronectin-induced fibroblast migration

2002 • 45 citations

Nerve growth factor abrogates the tumorigenicity of human small cell lung cancer cell lines

1998 • 45 citations

The role of sensory nerve endings in nerve growth factor‐induced airway hyperresponsiveness to histamine in guinea‐pigs

2001 • 44 citations

Massive lymphocyte apoptosis in the thymus of functionally deficient TrkB mice

2002 • 38 citations

Antibodies directed against nerve growth factor inhibit the acute bronchoconstriction due to allergen challenge in guinea-pigs

2002 • 36 citations

Age-dependent phenotypic switching of mast cells in NGF-transgenic mice

1995 • 36 citations

Nerve growth factor and retinoic acid interactions in the control of small cell lung cancer proliferation

2002 • 15 citations