Strategies in the design of antiviral drugs

Rational design of potent sialidase-based inhibitors of influenza virus replication

1993 • 1,819 citations

Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells

2000 • 1,122 citations

Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site: Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity

1997 • 1,070 citations

Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate

1997 • 1,023 citations

A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry

1999 • 1,019 citations

Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

1998 • 990 citations

RNA virus error catastrophe: Direct molecular test by using ribavirin

2001 • 819 citations

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

2000 • 812 citations

Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial

2000 • 779 citations

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

1999 • 752 citations

Efficacy and Safety of the Neuraminidase Inhibitor Zanamivir in the Treatment of Influenzavirus Infections

1997 • 747 citations

A novel selective broad-spectrum anti-DNA virus agent

1986 • 747 citations

Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4

1997 • 556 citations

Use of the Oral Neuraminidase Inhibitor Oseltamivir in Experimental Human Influenza

1999 • 544 citations

A Mouse Model for Evaluation of Prophylaxis and Therapy of Ebola Hemorrhagic Fever

1998 • 492 citations

Flavopiridol Inhibits P-TEFb and Blocks HIV-1 Replication

2000 • 457 citations

Inhibiting HIV-1 Entry

1999 • 433 citations

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

2000 • 430 citations

Structure and Mechanism of Inosine Monophosphate Dehydrogenase in Complex with the Immunosuppressant Mycophenolic Acid

1996 • 406 citations

Protein Design of an HIV-1 Entry Inhibitor

2001 • 387 citations

The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection1Presented at the Eleventh International Conference on Antiviral Research, San Diego, CA, 5–10 April 1998.1

1998 • 351 citations

Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion.

1996 • 327 citations

Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

1999 • 307 citations

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infectionin vitroandin vivo

2001 • 307 citations

Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

1998 • 283 citations

Antiviral drugs: current state of the art

2001 • 255 citations

Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection

1998 • 252 citations

Broad-Spectrum Antiviral Activity of the IMP Dehydrogenase Inhibitor VX-497: a Comparison with Ribavirin and Demonstration of Antiviral Additivity with Alpha Interferon

2000 • 247 citations

An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication

1997 • 241 citations

Protease Inhibitors as Antiviral Agents

1998 • 223 citations

In Vitro Antiviral Activity of AG7088, a Potent Inhibitor of Human Rhinovirus 3C Protease

1999 • 219 citations

Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.

1991 • 212 citations

Highly Potent and Selective Inhibition of Varicella-Zoster Virus by Bicyclic Furopyrimidine Nucleosides Bearing an Aryl Side Chain

2000 • 195 citations

4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells

2000 • 187 citations

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P₁ Lactam Moieties as <scp>l</scp>-Glutamine Replacements

1999 • 184 citations

Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation

1997 • 184 citations

Potent and Selective Inhibition of Varicella-Zoster Virus (VZV) by Nucleoside Analogues with an Unusual Bicyclic Base

1999 • 183 citations

Structural Mechanisms of HIV Drug Resistance

1996 • 177 citations

The HIV-1 Reverse Transcription (RT) Process as Target for RT Inhibitors

2000 • 175 citations

Cyclopentane Neuraminidase Inhibitors with Potent In Vitro Anti-Influenza Virus Activities

2001 • 166 citations

Vaccinia Virus Inhibitors as a Paradigm for the Chemotherapy of Poxvirus Infections

2001 • 165 citations

Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor

2001 • 156 citations

Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-l-homocysteine hydrolase inhibitor

2000 • 153 citations

Comparison of the Anti-Influenza Virus Activity of RWJ-270201 with Those of Oseltamivir and Zanamivir

2001 • 147 citations

A Mouse Model for Evaluation of Prophylaxis and Therapy of Ebola Hemorrhagic Fever

1999 • 138 citations

The Novel Immunosuppressive Agent Mycophenolate Mofetil Markedly Potentiates the Antiherpesvirus Activities of Acyclovir, Ganciclovir, and Penciclovir In Vitro and In Vivo

1998 • 135 citations

Therapeutic potential of HPMPC as an antiviral drug

1993 • 135 citations

cycloSal-2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine Monophosphate (cycloSal-d4TMP): Synthesis and Antiviral Evaluation of a New d4TMP Delivery System

1998 • 128 citations

Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4- carboxamide and related compounds

1991 • 123 citations

Binding of the Second Generation Non-nucleoside Inhibitor S-1153 to HIV-1 Reverse Transcriptase Involves Extensive Main Chain Hydrogen Bonding

2000 • 119 citations

The Herpesvirus Proteases as Targets for Antiviral Chemotherapy

2000 • 118 citations

Abacavir and Mycophenolic Acid, an Inhibitor of Inosine Monophosphate Dehydrogenase, Have Profound and Synergistic Anti-HIV Activity

1999 • 115 citations

Mutation of Asp¹⁷¹and Asp²⁶²of the Chemokine Receptor CXCR4 Impairs Its Coreceptor Function for Human Immunodeficiency Virus-1 Entry and Abrogates the Antagonistic Activity of AMD3100

2001 • 114 citations

Zanamivir Susceptibility Monitoring and Characterization of Influenza Virus Clinical Isolates Obtained during Phase II Clinical Efficacy Studies

2000 • 113 citations

Antiviral Drug Therapy of Filovirus Infections: S‐Adenosylhomocysteine Hydrolase Inhibitors Inhibit Ebola Virus In Vitro and in a Lethal Mouse Model

1999 • 113 citations

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 2. Peptide Structure−Activity Studies

1998 • 112 citations

Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives

1989 • 110 citations

Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists.

2000 • 109 citations

Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors

2000 • 108 citations

Human Immunodeficiency Virus Glycoprotein gp120 as the Primary Target for the Antiviral Action of AR177 (Zintevir)

1998 • 108 citations

Viral Entry as the Primary Target for the Anti-HIV Activity of Chicoric Acid and Its Tetra-Acetyl Esters

2000 • 106 citations

Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.

1999 • 104 citations

A General Model for the Surface Glycoproteins of HIV and Other Retroviruses

1995 • 102 citations

In Vivo Influenza Virus-Inhibitory Effects of the Cyclopentane Neuraminidase Inhibitor RWJ-270201

2001 • 97 citations

Poly(Sodium 4‐Styrene Sulfonate): An Effective Candidate Topical Antimicrobial for the Prevention of Sexually Transmitted Diseases

2000 • 93 citations

Retroviral integrase inhibitors year 2000: update and perspectives

2000 • 92 citations

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 1. Michael Acceptor Structure−Activity Studies

1998 • 89 citations

Herpes Simplex Virus Type 1 Entry Is Inhibited by the Cobalt Chelate Complex CTC-96

2001 • 84 citations

A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibition of human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry.

2000 • 83 citations

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. Part 7: Structure–Activity Studies of Bicyclic 2-Pyridone-Containing Peptidomimetics

2002 • 78 citations

Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones

1999 • 77 citations

Development of Resistance of Human Immunodeficiency Virus Type 1 to Dextran Sulfate Associated with the Emergence of Specific Mutations in the Envelope gp120 Glycoprotein

1997 • 77 citations

The Cyclohexene Ring System as a Furanose Mimic: Synthesis and Antiviral Activity of Both Enantiomers of Cyclohexenylguanine

2000 • 76 citations

HIV-1 Integrase as a Target for Antiviral Drugs

1997 • 73 citations

NS3 Serine Protease of Bovine Viral Diarrhea Virus: Characterization of Active Site Residues, NS4A Cofactor Domain, and Protease–Cofactor Interactions

2000 • 72 citations

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

2001 • 70 citations

Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 3. Structure−Activity Studies of Ketomethylene-Containing Peptidomimetics

1999 • 64 citations

Inhibition of human immunodeficiency virus type 1 replication and cytokine production by fluoroquinoline derivatives.

1998 • 64 citations

Novel Approaches to the Treatment of Hepatitis C Virus Infection

2000 • 63 citations

4-Hydroxy-5,6-dihydropyrones as Inhibitors of HIV Protease: The Effect of Heterocyclic Substituents at C-6 on Antiviral Potency and Pharmacokinetic Parameters

2001 • 60 citations

Cyclosaligenyl-2′,3′-didehydro-2′,3′-dideoxythymidine Monophosphate: Efficient Intracellular Delivery of d4TMP

2000 • 59 citations

Only a Small Fraction of Purified Hepatitis C RNA-Dependent RNA Polymerase Is Catalytically Competent: Implications for Viral Replication and in Vitro Assays

2000 • 59 citations

A Randomized 4–Arm Multicenter Study of Interferon Alfa-2B Plus Ribavirin in the Treatment of Patients With Chronic Hepatitis C Not Responding to Interferon Alone

2001 • 55 citations

Design and Synthesis of Lipophilic Phosphoramidate d4T-MP Prodrugs Expressing High Potency Against HIV in Cell Culture: Structural Determinants for in Vitro Activity and QSAR

1999 • 54 citations

Inhibition of Acute-, Latent-, and Chronic-Phase Human Immunodeficiency Virus Type 1 (HIV-1) Replication by a Bistriazoloacridone Analog That Selectively Inhibits HIV-1 Transcription

1998 • 54 citations

Synthesis and antiviral activity of monobactams inhibiting the human cytomegalovirus protease

1999 • 50 citations

Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors.

2000 • 47 citations

Abacavir and Mycophenolic Acid, an Inhibitor of Inosine Monophosphate Dehydrogenase, Have Profound and Synergistic Anti-HIV Activity

1999 • 46 citations

Design and Synthesis of Pyrrolidine-5,5-trans-lactams (5-Oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 1. The α-Methyl-trans-lactam Template

2000 • 44 citations

The identification of α-ketoamides as potent inhibitors of hepatitis c virus nS3-4a proteinase

2001 • 42 citations

Antiherpesvirus Activities of (1′ S ,2′ R )-9-{[1′,2′-Bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine (A-5021) in Cell Culture

1998 • 34 citations

Human Immunodeficiency Virus Gene Regulation as a Target for Antiviral Chemotherapy

1999 • 34 citations

Enzymatic properties of hepatitis C virus NS3-associated helicase

2000 • 33 citations

Models Which Explain the Inhibition of Reverse Transcriptase by HIV-1-Specific (Thio)carboxanilide Derivatives1

1997 • 30 citations

Mode of Action of (1′ S ,2′ R )-9-{[1′,2′-Bis(hydroxymethyl) cycloprop-1′-yl]methyl}guanine (A-5021) against Herpes Simplex Virus Type 1 and Type 2 and Varicella-Zoster Virus

1998 • 30 citations

Resistance of the Human Immunodeficiency Virus to the Inhibitory Action of Negatively Charged Albumins on Virus Binding to CD4

1999 • 19 citations

The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives

1999 • 18 citations

Selective Nonpeptidic Inhibitors of Herpes Simplex Virus Type 1 and Human Cytomegalovirus Proteases.

2001 • 13 citations