Binding of the Second Generation Non-nucleoside Inhibitor S-1153 to HIV-1 Reverse Transcriptase Involves Extensive Main Chain Hydrogen Bonding

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

1992 • 1,887 citations

An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

1997 • 1,724 citations

Changing patterns of mortality across Europe in patients infected with HIV-1

1998 • 1,284 citations

Interactive computer graphics: FRODO

1985 • 848 citations

Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Nonnucleoside Inhibitors

1995 • 523 citations

High resolution structures of HIV-1 RT from four RT–inhibitor complexes

1995 • 498 citations

L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

1995 • 472 citations

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

1995 • 435 citations

Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture.

1991 • 398 citations

The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection1Presented at the Eleventh International Conference on Antiviral Research, San Diego, CA, 5–10 April 1998.1

1998 • 351 citations

Complexes of HIV-1 Reverse Transcriptase with Inhibitors of the HEPT Series Reveal Conformational Changes Relevant to the Design of Potent Non-Nucleoside Inhibitors

1996 • 338 citations

Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors

1995 • 293 citations

Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor

1997 • 190 citations

The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design

1995 • 173 citations

S-1153 Inhibits Replication of Known Drug-Resistant Strains of Human Immunodeficiency Virus Type 1

1998 • 124 citations

Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication

1993 • 117 citations

Design of MKC-442 (Emivirine) Analogues with Improved Activity Against Drug-Resistant HIV Mutants

1999 • 112 citations

Crystal Structures of HIV-1 Reverse Transcriptase in Complex with Carboxanilide Derivatives^,

1998 • 80 citations

Crystals of HIV-1 Reverse Transcriptase Diffracting to 2·2 Å Resolution

1994 • 61 citations

Continuous and Discontinuous Changes in the Unit Cell of HIV-1 Reverse Transcriptase Crystals on Dehydration

1998 • 51 citations

Crystallographic Analysis of the Binding Modes of Thiazoloisoindolinone Non-Nucleoside Inhibitors to HIV-1 Reverse Transcriptase and Comparison with Modeling Studies

1999 • 39 citations

Combination therapy for HIV: the effect on inpatient activity, morbidity and mortality of a cohort of patients

1998 • 33 citations

Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains

1995 • 30 citations

EFAVIRENZ IN THE MANAGEMENT OF HIV INFECTION

1999 • 30 citations

Efavirenz in the management of HIV infection.

1999 • 27 citations