Magnetic resonance imaging measures of brain atrophy in multiple sclerosis

Voxel-Based Morphometry—The Methods

2000 • 8,281 citations

A nonparametric method for automatic correction of intensity nonuniformity in MRI data

1998 • 4,609 citations

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Accurate, Robust, and Automated Longitudinal and Cross-Sectional Brain Change Analysis

2002 • 1,962 citations

Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions

2001 • 1,377 citations

Multimodal Image Coregistration and Partitioning—A Unified Framework

1997 • 926 citations

Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

2000 • 918 citations

A Longitudinal Study of Abnormalities on MRI and Disability from Multiple Sclerosis

2002 • 852 citations

Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time

2002 • 766 citations

Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS

1999 • 728 citations

Axonal loss in multiple sclerosis lesions: Magnetic resonance imaging insights into substrates of disability

1999 • 713 citations

Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis

1998 • 652 citations

Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance

2002 • 635 citations

Evidence of Axonal Damage in the Early Stages of Multiple Sclerosis and Its Relevance to Disability

2001 • 507 citations

Normalized Accurate Measurement of Longitudinal Brain Change

2001 • 490 citations

Thalamic neurodegeneration in multiple sclerosis

2002 • 488 citations

Evidence of early cortical atrophy in MS

2003 • 485 citations

Progressive cerebral atrophy in multiple sclerosis A serial MRI study

1996 • 482 citations

Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis

1999 • 467 citations

Brain atrophy in clinically early relapsing–remitting multiple sclerosis

2002 • 456 citations

Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis

1999 • 426 citations

Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis

2000 • 404 citations

Focal thinning of the cerebral cortex in multiple sclerosis

2003 • 398 citations

A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis

2001 • 378 citations

Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes

2004 • 378 citations

Eight-year follow-up study of brain atrophy in patients with MS

2002 • 376 citations

Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis

2003 • 370 citations

Prediction of Neuropsychological Impairment in Multiple Sclerosis

2004 • 364 citations

A longitudinal study of brain atrophy in relapsing multiple sclerosis

1999 • 334 citations

Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis

2000 • 325 citations

Multiple sclerosis lesion quantification using fuzzy-connectedness principles

1997 • 325 citations

Brain atrophy progression measured from registered serial MRI: Validation and application to alzheimer's disease

1997 • 324 citations

Neocortical volume decrease in relapsing–remitting MS patients with mild cognitive impairment

2004 • 316 citations

Electrically active axons degenerate when exposed to nitric oxide

2001 • 308 citations

Oligodendrocytes Promote Neuronal Survival and Axonal Length by Distinct Intracellular Mechanisms: A Novel Role for Oligodendrocyte-Derived Glial Cell Line-Derived Neurotrophic Factor

2003 • 278 citations

Interactive algorithms for the segmentation and quantitation of 3-D MRI brain scans

1997 • 277 citations

Interferon beta-1a for brain tissue loss in patients at presentation with syndromes suggestive of multiple sclerosis: a randomised, double-blind, placebo-controlled trial

2004 • 254 citations

Oligodendroglia Regulate the Regional Expansion of Axon Caliber and Local Accumulation of Neurofilaments during Development Independently of Myelin Formation

1996 • 247 citations

The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis

2000 • 236 citations

Cognitive function in primary progressive and transitional progressive multiple sclerosis: A controlled study with MRI correlates

1999 • 230 citations

Brain Atrophy in Relapsing-Remitting Multiple Sclerosis and Secondary Progressive Multiple Sclerosis: Longitudinal Quantitative Analysis

2000 • 219 citations

Progressive cerebral atrophy in MS

2000 • 218 citations

Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis

2004 • 215 citations

Thalamic neurodegeneration in relapsing-remitting multiple sclerosis

2003 • 184 citations

Detection of ventricular enlargement in patients at the earliest clinical stage of MS

2000 • 184 citations

Relationship between brain atrophy and disability: an 8-year follow-up study of multiple sclerosis patients

2000 • 180 citations

Three dimensional MRI estimates of brain and spinal cord atrophy in multiple sclerosis

1999 • 177 citations

Regional brain atrophy evolves differently in patients with multiple sclerosis according to clinical phenotype.

2005 • 171 citations

Gray and white matter volume changes in early RRMS

2005 • 163 citations

Progressive ventricular enlargement in patients with clinically isolated syndromes is associated with the early development of multiple sclerosis

2002 • 158 citations

A Robust Method for Extraction and Automatic Segmentation of Brain Images

2002 • 157 citations

Short-term brain volume change in relapsing-remitting multiple sclerosis: Effect of glatiramer acetate and implications

2001 • 156 citations

ACUTE INTERSTITIAL NEPHRITIS

1898 • 154 citations

Longitudinal Brain Volume Measurement in Multiple Sclerosis

2002 • 153 citations

Bicaudate Ratio as a Magnetic Resonance Imaging Marker of Brain Atrophy in Multiple Sclerosis

2002 • 150 citations

The reproducibility and sensitivity of brain tissue volume measurements derived from an SPM‐based segmentation methodology

2002 • 142 citations

A Longitudinal Study of Callosal Atrophy and Interhemispheric Dysfunction in Relapsing-Remitting Multiple Sclerosis

2001 • 140 citations

Conventional and magnetization transfer MRI predictors of clinical multiple sclerosis evolution: a medium-term follow-up study

2003 • 134 citations

Primary progressive multiple sclerosis: a 5-year clinical and MR study

2003 • 132 citations

Use of the Multiple Sclerosis Functional Composite to predict disability in relapsing MS

2001 • 127 citations

Heterogeneity of congnitive profiles in aging: successful aging, normal aging, and individuals at risks for cognitive decline

1999 • 125 citations

Brain atrophy in relapsing multiple sclerosis: relationship to relapses, EDSS, and treatment with interferon β-1a

2000 • 125 citations

A semiautomated measure of whole-brain atrophy in multiple sclerosis

2003 • 124 citations

Brain atrophy in relapsing-remitting multiple sclerosis: relationship with ‘black holes’, disease duration and clinical disability

2000 • 122 citations

Correction of differential intensity inhomogeneity in longitudinal MR images

2004 • 121 citations

Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis

2004 • 120 citations

Progressive grey matter atrophy in clinically early relapsing-remitting multiple sclerosis

2004 • 119 citations

One year follow up study of primary and transitional progressive multiple sclerosis

2000 • 116 citations

Accelerated evolution of brain atrophy and “black holes” in MS patients with APOE‐ε4

2004 • 115 citations

MRI techniques and cognitive impairment in the early phase of relapsing-remitting multiple sclerosis

2001 • 115 citations

Selective caudate atrophy in multiple sclerosis: a 3D MRI parcellation study

2003 • 112 citations

Rate of brain atrophy in relapsing MS decreases during treatment with IFNβ-1a

2005 • 101 citations

Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation.

2004 • 99 citations

The longitudinal relation between brain lesion load and atrophy in multiple sclerosis: a 14 year follow up study

2003 • 97 citations

Grey and white matter atrophy in early clinical stages of primary progressive multiple sclerosis

2004 • 93 citations

The Relationship between inflammation and atrophy in clinically isolated syndromes suggestive of multiple sclerosis

2004 • 72 citations

The relationship of brain and cervical cord volume to disability in clinical subtypes of multiple sclerosis: a three-dimensional MRI study

2003 • 71 citations

A 6‐year clinical and MRI follow‐up study of patients with relapsing–remitting multiple sclerosis treated with Interferon‐beta

2002 • 69 citations

Whole-brain atrophy in multiple sclerosis measured by automated versus semiautomated MR imaging segmentation.

2004 • 67 citations

C erebral atrophy and disability in relapsing-remitting and secondary progressive multiple sclerosis over four years

2003 • 63 citations

Ventricular enlargement in multiple sclerosis: a comparison of three-dimensional and linear MRI estimates

2001 • 63 citations

Volumes of brain atrophy and plaques correlated with neurological disability in secondary progressive multiple sclerosis

1999 • 59 citations

MRI brain volume changes in relapsing-remitting multiple sclerosis patients treated with interferon beta-1a

2002 • 57 citations

Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis

2004 • 56 citations

Influence of Apolipoprotein E ϵ4 Genotype on Brain Tissue Integrity in Relapsing-Remitting Multiple Sclerosis

2004 • 51 citations

Automatic measurement of changes in brain volume on consecutive 3D MR images by segmentation propagation

2000 • 51 citations

Sensitivity and reproducibility of volume change measurements of different brain portions on magnetic resonance imaging in patients with multiple sclerosis

2000 • 50 citations

Whole-brain atrophy in multiple sclerosis measured by two segmentation processes from various MRI sequences

2003 • 50 citations

Frontal Cortex Atrophy Predicts Cognitive Impairment in Multiple Sclerosis

2002 • 48 citations

A longitudinal study of ventricular volume in early relapsing-remitting multiple sclerosis

2000 • 46 citations

Automated Estimation of Brain Volume in Multiple Sclerosis with BICCR

2001 • 45 citations

Atrophy Is Detectable Within a 3-Month Period in Untreated Patients With Active Relapsing Remitting Multiple Sclerosis

2003 • 45 citations

Two-year follow-up study of primary and transitional progressive multiple sclerosis

2002 • 45 citations

Is Multivariate Analysis of PET Data More Revealing Than the Univariate Approach? Evidence from a Study of Episodic Memory Retrieval

1996 • 43 citations

Short-term brain atrophy changes in relapsing–remitting multiple sclerosis

2004 • 41 citations

Inflammation and atrophy in multiple sclerosis: MRI associations with disease course

2001 • 40 citations

No major association of A poE genotype with disease characteristics and MRI findings in multiple sclerosis

2004 • 39 citations

Monitoring disease activity and progression in primary progressive multiple sclerosis using MRI: sub-voxel registration to identify lesion changes and to detect cerebral atrophy

2002 • 37 citations

Venous angioma of the optic chiasm

1978 • 35 citations

Age-related brain parenchymal fraction is significantly decreased in young multiple sclerosis patients: a quantitative MRI study

2003 • 32 citations

Intra-observer, inter-observer and inter-scanner variations in brain MRI volume measurements in multiple sclerosis

2001 • 30 citations

Estimating cerebral atrophy in multiple sclerosis patients from various MR pulse sequences

2002 • 26 citations

Corpus Callosum Axonal Injury in Multiple Sclerosis Measured by Proton Magnetic Resonance Spectroscopic Imaging

2004 • 21 citations

Axonal Damage in Multiple Sclerosis Patients with High versus Low Expanded Disability Status Scale Score

2004 • 20 citations

Serial MRI in multiple sclerosis: a prospective pilot study of lesion load, whole brain volume and thalamic atrophy

2003 • 12 citations