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Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance

Data up to Jan 2025

Published2002
Citations635
References91

Total Citations Per Year

Abstract

References (91)

Voxel-Based Morphometry—The Methods

2000 • 8,281 citations

Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm

2001 • 6,645 citations

A nonparametric method for automatic correction of intensity nonuniformity in MRI data

1998 • 4,609 citations

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Axonal damage in acute multiple sclerosis lesions

1997 • 1,543 citations

A Quantitative Magnetic Resonance Imaging Study of Changes in Brain Morphology From Infancy to Late Adulthood

1994 • 1,385 citations

Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study

2001 • 1,077 citations

Normal Brain Development and Aging: Quantitative Analysis at in Vivo MR Imaging in Healthy Volunteers

2000 • 1,042 citations

Adaptive fuzzy segmentation of magnetic resonance images

1999 • 803 citations

Cortical lesions in multiple sclerosis

1999 • 767 citations

Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS

1999 • 728 citations

Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis

1998 • 652 citations

Spinal cord atrophy and disability in multiple sclerosis

1996 • 618 citations

Normalized Accurate Measurement of Longitudinal Brain Change

2001 • 490 citations

Quantitative cerebral anatomy of the aging human brain

1992 • 486 citations

The prognostic value of brain MRI in clinically isolated syndromes of the CNS. A 10-year follow-up

1998 • 483 citations

Progressive cerebral atrophy in multiple sclerosis A serial MRI study

1996 • 482 citations

An adaptive fuzzy C-means algorithm for image segmentation in the presence of intensity inhomogeneities

1999 • 479 citations

Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis

1999 • 467 citations

Brain atrophy in clinically early relapsing–remitting multiple sclerosis

2002 • 456 citations

Gender differences in age effect on brain atrophy measured by magnetic resonance imaging.

1991 • 447 citations

Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis

2000 • 404 citations

The boundary shift integral: an accurate and robust measure of cerebral volume changes from registered repeat MRI

1997 • 380 citations

Brain and spinal cord abnormalities in multiple sclerosis. Correlation between MRI parameters, clinical subtypes and symptoms

1998 • 376 citations

Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis

2000 • 367 citations

Axonal changes in chronic demyelinated cervical spinal cord plaques

2000 • 350 citations

Spinal cord MRI using multi‐array coils and fast spin echo

1993 • 339 citations

Sex differences in aging of the human frontal and temporal lobes

1994 • 338 citations

A longitudinal study of brain atrophy in relapsing multiple sclerosis

1999 • 334 citations

Normalization of Cerebral Volumes by Use of Intracranial Volume: Implications for Longitudinal Quantitative MR Imaging

2001 • 332 citations

Multiple sclerosis lesion quantification using fuzzy-connectedness principles

1997 • 325 citations

Cladribine and progressive MS

2000 • 317 citations

An Image-Processing System for Qualitative and Quantitative Volumetric Analysis of Brain Images

1998 • 297 citations

The motor cortex shows adaptive functional changes to brain injury from multiple sclerosis

2000 • 269 citations

Method for Quantification of Brain, Ventricular, and Subarachnoid CSF Volumes from MR Images

1992 • 257 citations

Correction for head size in brain-imaging measurements

1993 • 241 citations

Modeling Brain Deformations in Alzheimer Disease by Fluid Registration of Serial 3D MR Images

1998 • 239 citations

The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis

2000 • 236 citations

Brain segmentation and white matter lesion detection in MR images.

1994 • 231 citations

Spinal cord atrophy and disability in MS

1998 • 230 citations

Cognitive function in primary progressive and transitional progressive multiple sclerosis: A controlled study with MRI correlates

1999 • 230 citations

Macrophage function during Wallerian degeneration of rat optic nerve: clearance of degenerating myelin and Ia expression

1989 • 228 citations

Brain Atrophy in Relapsing-Remitting Multiple Sclerosis and Secondary Progressive Multiple Sclerosis: Longitudinal Quantitative Analysis

2000 • 219 citations

Progressive cerebral atrophy in MS

2000 • 218 citations

Quantitative MRI in patients with secondary progressive MS treated with monoclonal antibody Campath 1H

1999 • 218 citations

Recovery from optic neuritis is associated with a change in the distribution of cerebral response to visual stimulation: a functional magnetic resonance imaging study

2000 • 210 citations

Spinal cord axonal loss in multiple sclerosis: a post‐mortem study

1999 • 203 citations

Detection of ventricular enlargement in patients at the earliest clinical stage of MS

2000 • 184 citations

Fast, accurate, and reproducible automatic segmentation of the brain in T1-weighted volume MRI data

1999 • 183 citations

Relationship between brain atrophy and disability: an 8-year follow-up study of multiple sclerosis patients

2000 • 180 citations

Three dimensional MRI estimates of brain and spinal cord atrophy in multiple sclerosis

1999 • 177 citations

IMMUNOGLOBULIN-CONTAINING CELLS IN MULTIPLE-SCLEROSIS PLAQUES

1977 • 176 citations

White matter abnormalities in mobility-impaired older persons

2000 • 168 citations

Accurate Registration of Serial 3D MR Brain Images and Its Application to Visualizing Change in Neurodegenerative Disorders

1996 • 161 citations

Short-term brain volume change in relapsing-remitting multiple sclerosis: Effect of glatiramer acetate and implications

2001 • 156 citations

Glatiramer acetate (Copaxone) treatment in relapsing–remitting MS

2000 • 142 citations

Optimizing the association between disability and biological markers in MS

2001 • 137 citations

Linomide in relapsing and secondary progressive MS

2000 • 135 citations

Histopathology and the blood-cerebrospinal fluid barrier in multiple sclerosis

1994 • 127 citations

Whole brain volume changes in patients with progressive MS treated with cladribine

2000 • 123 citations

Brain atrophy in relapsing-remitting multiple sclerosis: relationship with ‘black holes’, disease duration and clinical disability

2000 • 122 citations

Infratentorial atrophy on magnetic resonance imaging and disability in multiple sclerosis

1999 • 119 citations

One year follow up study of primary and transitional progressive multiple sclerosis

2000 • 116 citations

Automatic quantification of multiple sclerosis lesion volume using stereotaxic space

1996 • 115 citations

A spinal cord MRI study of benign and secondary progressive multiple sclerosis

1996 • 111 citations

Measurement of spinal cord area in clinically isolated syndromes suggestive of multiple sclerosis

2001 • 109 citations

Quantitative follow-up of patients with multiple sclerosis using MRI: Technical aspects

1999 • 103 citations

Quantitative follow-up of patients with multiple sclerosis using MRI: Reproducibility

1999 • 100 citations

United States open-label glatiramer acetate extension trial for relapsing multiple sclerosis: MRI and clinical correlates

2001 • 98 citations

Detection of optic nerve atrophy following a single episode of unilateral optic neuritis by MRI using a fat-saturated short-echo fast FLAIR sequence

2001 • 95 citations

T1 lesion load and cerebral atrophy as a marker for clinical progression in patients with multiple sclerosis. A prospective 18 months follow‐up study

2001 • 94 citations

Haemodialysis and Cerebral Oedema

2001 • 91 citations

United States open-label glatiramer acetate extension trial for relapsing multiple sclerosis: MRI and clinical correlates

2001 • 79 citations

Quantitative contrast-enhanced magnetic resonance imaging to evaluate blood-brain barrier integrity in multiple sclerosis: a preliminary study

2001 • 74 citations

A dual approach for minimizing false lesion classifications on magnetic resonance images

1997 • 63 citations

Quantitative volumetric analysis of brain magnetic resonance imaging from patients with multiple sclerosis

1998 • 59 citations

Catch-Up Growth in Short-at-Birth NICU Graduates

2000 • 57 citations

MRI brain volume changes in relapsing-remitting multiple sclerosis patients treated with interferon beta-1a

2002 • 57 citations

Sensitivity and reproducibility of volume change measurements of different brain portions on magnetic resonance imaging in patients with multiple sclerosis

2000 • 50 citations

G Protein Defects in Signal Transduction

2000 • 48 citations

The effect of gadolinium-enhancing lesions on whole brain atrophy in relapsing-remitting MS

2000 • 47 citations

Volumetric analysis of white matter, gray matter, and CSF using fractional volume analysis

1998 • 45 citations

Automated Estimation of Brain Volume in Multiple Sclerosis with BICCR

2001 • 45 citations

Exploratory treatment trials in multiple sclerosis using MRI: sample size calculations for relapsing-remitting and secondary progressive subgroups using placebo controlled parallel groups

1998 • 44 citations

A Longitudinal Magnetic Resonance Imaging Study of the Cervical Cord in Multiple Sclerosis

1997 • 43 citations

Some Spaces and Barriers in Postmortem Multiple Sclerosis

1968 • 41 citations

A Colour Atlas of Multiple Sclerosis and Other Myelin Disorders

1989 • 33 citations

<title>Knowledge-based 3D segmentation of the brain in MR images for quantitative multiple sclerosis lesion tracking</title>

1997 • 22 citations

Quantitative brain volumetric analysis from patients with multiple sclerosis: a follow-up study

1999 • 21 citations

Reproducibility of magnetic resonance imaging measurements of spinal cord atrophy: the role of quality assurance

1999 • 18 citations

Deleted Work

1955 • 0 citations

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