Modulation of the Mesolimbic Dopamine System by Glutamate

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

A stereotaxic atlas of the rat brain

1967 • 4,710 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

The projections of the ventral tegmental area and adjacent regions: A combined fluorescent retrograde tracer and immunofluorescence study in the rat

1982 • 1,693 citations

The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants

1998 • 936 citations

The nucleus accumbens as a complex of functionally distinct neuronal ensembles: An integration of behavioural, electrophysiological and anatomical data

1994 • 807 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

Dendritic release of dopamine in the substantia nigra

1981 • 732 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

THE EFFECTS OF A SERIES OF ω‐PHOSPHONIC α‐CARBOXYLIC AMINO ACIDS ON ELECTRICALLY EVOKED AND EXCITANT AMINO ACID‐INDUCED RESPONSES IN ISOLATED SPINAL CORD PREPARATIONS

1982 • 463 citations

The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice

1989 • 426 citations

Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo

1993 • 386 citations

The pharmacology of mesolimbic dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and nucleus accumbens of the rat brain

1996 • 376 citations

The Basal Ganglia and Cognitive Pattern Generators

1997 • 355 citations

Tonic Activation of NMDA Receptors Causes Spontaneous Burst Discharge of Rat Midbrain Dopamine Neurons In Vivo

1993 • 350 citations

GABA-containing neurons in the ventral tegmental area project to the nucleus accumbens in rat brain

1995 • 326 citations

Dopamine neurons make glutamatergic synapses in vitro.

1998 • 320 citations

Regulation of dopamine release by impulse flow and by autoreceptors as studied by in vivo voltammetry in the rat striatum

1985 • 317 citations

Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors

1995 • 316 citations

Relationship between dopamine release in the rat nucleus accumbens and the discharge activity of dopaminergic neurons during local in vivo application of amino acids in the ventral tegmental area

1992 • 315 citations

New class of glutamate agonist structurally related to ibotenic acid

1980 • 309 citations

Dopamine Neurons Make Glutamatergic SynapsesIn Vitro

1998 • 288 citations

Dopamine release in the nucleus caudatus and in the nucleus accumbens is under glutamatergic control through non-NMDA receptors: a study in freely-moving rats

1990 • 260 citations

CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.

1987 • 231 citations

NMDA receptors and in vivo dopamine release in the nucleus accumbens and caudatus

1990 • 221 citations

Pharmacological characterization of dopamine autoreceptors in the rat ventral tegmental area: microiontophoretic studies.

1984 • 220 citations

Dopamine Synaptic Mechanisms Reflected in Studies Combining Behavioural Recordings and Brain Dialysis

1982 • 210 citations

CGP 37849 and CGP 39551: novel and potent competitive N‐methyl‐<scp>d</scp>‐aspartate receptor antagonists with oral activity

1990 • 186 citations

Glutamate antagonists have different effects on spontaneous locomotor activity in rats

1994 • 186 citations

The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity

1984 • 181 citations

Characteristics of Electrically Evoked Somatodendritic Dopamine Release in Substantia Nigra and Ventral Tegmental Area In Vitro

1997 • 172 citations

Excitatory amino acid antagonists and memory: Effect of drugs acting at N-methyl-d-aspartate receptors in learning and memory tasks

1990 • 169 citations

A Comparison of Axonal and Somatodendritic Dopamine Release Using In Vivo Dialysis

1991 • 161 citations

GABA_A Receptor Blockade in the Anterior Ventral Tegmental Area Increases Extracellular Levels of Dopamine in the Nucleus Accumbens of Rats

1997 • 154 citations

Differential behavioural and neurochemical effects of competitive and non-competitive NMDA receptor antagonists in rats

1992 • 140 citations

MK-801-induced stereotypy and its antagonism by neuroleptic drugs

1990 • 138 citations

Dizocilpine (MK-801) increases not only dopamine but also serotonin and norepinephrine transmissions in the nucleus accumbens as measured by microdialysis in freely moving rats

1997 • 133 citations

Excitatory Amino Acid Receptors in the Ventral Tegmental Area Regulate Dopamine Release in the Ventral Striatum

1996 • 130 citations

Electrophysiological effects of MK-801 on rat nigrostriatal and mesoaccumbal dopaminergic neurons

1992 • 130 citations

Prazosin inhibits MK-801-induced hyperlocomotion and dopamine release in the nucleus accumbens

1996 • 125 citations

MK-801, phencyclidine (PCP), and PCP-like drugs increase burst firing in rat A10 dopamine neurons: Comparison to competitive NMDA antagonists

1993 • 122 citations

Intrastriatal injection of dl-2-amino-5-phosphonovaleric acid (AP-5) induces sniffing stereotypy that is antagonized by haloperidol and clozapine

1986 • 118 citations

Regional effects of MK-801 on dopamine release: effects of competitive NMDA or 5-HT2A receptor blockade.

1996 • 117 citations

NMDA receptors mediate the behavioral effects of amphetamine infused into the nucleus accumbens

1992 • 114 citations

Interactions of Phencyclidine Receptor Agonist MK‐801 with Dopaminergic System: Regional Studies in the Rat

1990 • 112 citations

Behavioural pharmacology of glutamate receptors in the basal ganglia

1997 • 111 citations

Effects of dizocilpine (MK-801) on rat midbrain dopamine cell activity: differential actions on firing pattern related to anatomical localization

1993 • 111 citations

Distinct actions of endogenous excitatory amino acids on the outflow of dopamine in the nucleus accumbens.

1993 • 110 citations

The role of dopamine and AMPA/kainate receptors in the nucleus accumbens in the hypermotility response to MK801

1993 • 90 citations

Opposite changes in the mesolimbic dopamine metabolism in the nerve terminal and cell body sites induced by locally infused baclofen in the rat

1994 • 88 citations

A comparison between the non-competitive NMDA antagonist dizocilpine (MK-801) and the competitive NMDA antagonist D-CPPene with regard to dopamine turnover and locomotor-stimulatory properties in mice

1991 • 88 citations

Increases in extracellular dopamine levels and locomotor activity after direct infusion of phencyclidine into the nucleus accumbens

1992 • 85 citations

Glutamate modulates dopamine release in the striatum as measured by brain microdialysis

1990 • 79 citations

The excitatory amino acid antagonist kynurenate induces pacemaker‐like firing of dopamine neurons in rat ventral tegmental area in vivo

1998 • 78 citations

Effects of phencyclidine on ventral tegmental A10 dopamine neurons in the rat

1986 • 68 citations

MK-801 increases locomotor activity without elevating extracellular dopamine levels in the nucleus accumbens

1996 • 67 citations

Locomotor activation induced by MK-801 in the rat: postsynaptic interactions with dopamine receptors in the ventral striatum

1994 • 65 citations

Phencyclidine and the midbrain dopamine system: Electrophysiology and behavior

1994 • 61 citations

The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior

1992 • 57 citations

demonstration of the enhancement of MK-801 by L-glutamate

1989 • 57 citations

Effects of competitive N-methyl-d-aspartate antagonists on midbrain dopamine neurons: An electrophysiological and behavioral comparison to phencyclidine

1991 • 54 citations

The excitatory amino acid antagonist kynurenate induces pacemaker‐like firing of dopamine neurons in rat ventral tegmental area in vivo

1988 • 40 citations

Decreases in rat locomotor activity as a result of changes in synaptic transmission to neurons within the mesencephalic locomotor region

1993 • 36 citations

Competitive NMDA receptor antagonists do not produce locomotor hyperactivity by a dopamine-dependent mechanism

1995 • 33 citations

Effects of antiischemic drugs on veratridine-induced hypercontracture in rat cardiac myocytes

1994 • 30 citations

Neurochemical Interactions of Competitive N‐Methyl‐D‐Aspartate Antagonists with Dopaminergic Neurotransmission and the Cerebellar Cyclic GMP System: Functional Evidence for a Phasic Glutamatergic Control of the Nigrostriatal Dopaminergic Pathway

1991 • 29 citations

Behavioral effects mediated by the modulatory glycine site of the NMDA receptor in the anterodorsal striatum and nucleus accumbens

1996 • 29 citations

Simultaneous recording of the release of nigral and striatal dopamine in the awake rat

1992 • 28 citations

Hyperactivity induced by N-methyl-d-aspartate injections into nucleus accumbens: Lack of evidence for mediation by dopaminergic neurons

1989 • 27 citations

The behavioral effects of MK-801 injected into nucleus accumbens and caudate-putamen of rats

1995 • 26 citations

The pharmacology of SDZ EAA 494, a competitive NMDA antagonist

1994 • 26 citations

Competitive NMDA receptor antagonists attenuate phencyclidine-induced excitations of A10 dopamine neurons

1992 • 22 citations

Balance of transmitter activities in the basal ganglia loops.

1995 • 20 citations

Contrasting Neurochemical Interactions of Tiletamine, a Potent Phencyclidine (PCP) Receptor Ligand, with the N‐Methyl‐D‐Aspartate‐Coupled and ‐Uncoupled PCP Recognition Sites

1991 • 18 citations

Behavioural pharmacology of the non-competitive NMDA antagonists dextrorphan and ADCI: relations between locomotor stimulation, anticataleptic potential and forebrain dopamine metabolism

1997 • 14 citations

Phencyclidine-induced activation of ventral tegmental A10 dopamine neurons is differentially affected by lesions of the nucleus accumbens and medial prefrontal cortex

1989 • 13 citations

Stimulation of locomotor activity by intra-accumbens AMPA is not inhibited by neonatal 6-hydroxydopamine-induced lesions

1992 • 11 citations

Are N-methyl-d-aspartate (NMDA) and phencyclidine (PCP) receptors always functionally coupled to each other?

1990 • 10 citations

Deleted Work

1955 • 0 citations