The inhibitory effects of β-amyloid on glutamate and glucose uptakes by cultured astrocytes

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

1994 • 2,646 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1991 • 2,375 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Fine structural localization of glutamine synthetase in astrocytes of rat brain

1979 • 1,318 citations

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism.

1992 • 1,121 citations

The release and uptake of excitatory amino acids

1990 • 1,090 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Positron emission tomography in Alzheimer's disease

1986 • 563 citations

Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease

1994 • 448 citations

Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex

1989 • 390 citations

Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25–35

1993 • 343 citations

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1992 • 291 citations

Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain

1989 • 281 citations

Effects of injected Alzheimer beta-amyloid cores in rat brain.

1991 • 255 citations

Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture

1992 • 251 citations

Amyloid β Peptide (25–35) Inhibits Na⁺‐Dependent Glutamate Uptake in Rat Hippocampal Astrocyte Cultures

1996 • 225 citations

Comparative effects of some nitric oxide donors on cyclic GMP levels in rat cerebellar slices

1991 • 207 citations

The elusive transporters with a high affinity for glutamate

1993 • 195 citations

Diminished Glucose Transport in Alzheimer's Disease: Dynamic PET Studies

1991 • 181 citations

Microglial release of nitric oxide by the synergistic action of β-amyloid and IFN-γ

1995 • 165 citations

The autoradiographic localization of L-[3H]glutamate in rat brain tissue

1976 • 160 citations

Astrocyte glutamate uptake during chemical hypoxia in vitro

1992 • 116 citations

β-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimerʼs disease

1995 • 114 citations

Induction of basic Fibroblast Growth Factor in Alzheimerʼs disease pathology

1990 • 112 citations

Characterization of glutamate uptake systems in astrocyte primary cultures from rat brain

1991 • 112 citations

Abnormalities of Glucose Metabolism in Alzheimer's Disease

1991 • 109 citations

Nitric oxide inhibits ³H‐glutamate transport in synaptosomes

1994 • 105 citations

Glutamate Increases Glycogen Content and Reduces Glucose Utilization in Primary Astrocyte Culture

1990 • 100 citations

Functional Alterations in Alzheimerʼs Disease

1995 • 99 citations

Glutamate Metabolism in Rat Cortical Astrocyte Cultures

1992 • 98 citations

Glutamate uptake by astrocytes is inhibited by reactive oxygen intermediates but not by other macrophage-derived molecules including cytokines, leukotrienes or platelet-activating factor

1993 • 85 citations

Glucose Can Fuel Glutamate Uptake in Ischemic Brain

1994 • 81 citations

Calcium and cell death.

1989 • 70 citations

Release of Excitatory Amino Acids from Cultured Hippocampal Astrocytes Induced by a Hypoxic-Hypoglycemic Stimulation

1992 • 63 citations

Abnormal Brain Glucose Metabolism in Alzheimer’s Disease, as Measured by Positron Emission Tomography

1991 • 59 citations

Amyloid β-protein fragment 25–35 causes activation of cytoplasmic calcium in neurons

1992 • 59 citations

Altered glucose metabolism in microvessels from patients with Alzheimer's disease

1989 • 54 citations

Characteristics of Glucose Transport in Neuronal Cells and Astrocytes from Rat Brain in Primary Culture

1989 • 52 citations

Antagonism by Ng-nitro-l-arginine ofl-glutamate-induced neurotoxicity in cultured neonatal rat cortical neurons. Prolonged application enhances neuroprotective efficacy

1993 • 49 citations

Cognitive and brain imaging measures of Alzheimer's disease

1988 • 48 citations

Early senile plaques in Alzheimer's disease demonstrated by histochemistry, immunocytochemistry, and electron microscopy

1990 • 46 citations

Oxidative stress after acute and chronic application of β-amyloid fragment 25–35 in cortical cultures

1996 • 37 citations

Molecular and cellular biology of Alzheimer amyloid

1992 • 36 citations