Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

Neuroactive steroids

1992 • 1,260 citations

Non-genomic and genomic effects of steroids on neural activity

1991 • 731 citations

Steroid Hormone Receptors: Interaction with Deoxyribonucleic Acid and Transcription Factors*

1993 • 724 citations

Neurosteroids and GABAA receptor function

1995 • 705 citations

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

1998 • 658 citations

Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

1999 • 632 citations

GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid

1998 • 568 citations

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

1988 • 531 citations

Neurosteroids act on recombinant human GABAA receptors

1990 • 515 citations

Inhibition of oxytocin receptor function by direct binding of progesterone

1998 • 468 citations

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.

1988 • 459 citations

Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor

1991 • 454 citations

Effects of Antidepressant Treatment on Neuroactive Steroids in Major Depression

1998 • 445 citations

Anxiolytic Effect of Progesterone is Mediated by the Neurosteroid Allopregnanolone at Brain GABA_A Receptors

1995 • 385 citations

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

1999 • 384 citations

Anticonvulsant activity of neurosteroids: correlation with gamma-aminobutyric acid-evoked chloride current potentiation.

1994 • 343 citations

Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography.

1996 • 329 citations

Anxiolytic activity of an endogenous adrenal steroid

1986 • 317 citations

Neuroactive Steroid 3α-Hydroxy-5α-Pregnan-20-One Modulates Electrophysiological and Behavioral Actions of Ethanol

2000 • 317 citations

The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus

1994 • 302 citations

Progesterone receptor-mediated effects of neuroactive steroids

1993 • 297 citations

Neurosteroids: a new function in the brain

1991 • 296 citations

Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one

1991 • 293 citations

Effects of intravenous progesterone infusions on the epileptic discharge frequency in women with partial epilepsy

1984 • 245 citations

Generating and testing a causal explanation of the gender difference in age at first onset of schizophrenia

1993 • 244 citations

Antidepressant-like effect of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in mice forced swim test

2000 • 223 citations

Neuroactive steroids: potential therapeutic use in neurological and psychiatric disorders

1999 • 216 citations

Progesterone therapy in women with complex partial and secondary generalized seizures

1995 • 216 citations

Concentrations of 3α-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery

1999 • 189 citations

Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators

1996 • 174 citations

Neurosteroid metabolism. 7α-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes

1992 • 165 citations

The neuropsychopharmacological potential of neuroactive steroids

1997 • 164 citations

A clinical trial of the effects of estrogen in acutely psychotic women

1996 • 164 citations

Progesterone-induced changes in sleep in male subjects

1997 • 161 citations

The Neurosteroid, 3α‐Hydroxy‐5α‐pregnan‐20‐one, Protects against Bicuculline‐Induced Seizures during Ethanol Withdrawal in Rats

1995 • 161 citations

Allopregnanolone affects sleep in a benzodiazepine-like fashion.

1997 • 143 citations

Sleep induction by an adrenal steroid in the rat

1987 • 142 citations

Variation in symptom severity over the menstrual cycle of Schizophrenics

1993 • 142 citations

Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex

1990 • 141 citations

Functional Antagonism of Gonadal Steroids at the 5-Hydroxytryptamine Type 3 Receptor

1998 • 125 citations

Marked Decrease of Plasma Neuroactive Steroids During Alcohol Withdrawal

1996 • 124 citations

Initial Human Experience with Ganaxolone, a Neuroactive Steroid with Antiepileptic Activity

1997 • 122 citations

Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events.

1997 • 120 citations

Anti-seizure effects of progesterone and 3α,5α-THP in kainic acid and perforant pathway models of epilepsy

2000 • 113 citations

Effects of Chronic Ethanol Consumption and Withdrawal on the Neuroactive Steroid 3alpha-Hydroxy-5alpha-pregnan-20-one in Male and Female Rats

1998 • 113 citations

Olanzapine increases allopregnanolone in the rat cerebral cortex

2000 • 103 citations

Fluoxetine decreases concentrations of 3α,5α-tetrahydrodeoxycorticosterone (THDOC) in major depression

2000 • 87 citations

Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor.

1994 • 85 citations

Assessment of neuroleptic-like properties of progesterone

1999 • 62 citations

Steroid receptor-mediated effects of neuroactive steroids: characterization of structure-activity relationship

1996 • 61 citations

CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat.

1997 • 60 citations

The Influence of Subchronic Administration of the Neurosteroid Allopregnanolone on Sleep in the Rat

2001 • 52 citations

The GABA A receptor antagonist picrotoxin attenuates most sleep changes induced by progesterone

1999 • 37 citations

Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptors.

2000 • 34 citations

Functional Antagonism of Gonadal Steroids at the 5-Hydroxytryptamine Type 3 Receptor

1998 • 34 citations

3α-Hydroxy-5α-pregnan-20-one exposure reduces GABAA receptor α4 subunit mRNA levels

2000 • 34 citations

Effects of Fluoxetine, Indomethacine and Placebo on 3α, 5α Tetrahydroprogesterone (THP) Plasma Levels in Uncomplicated Alcohol Withdrawal

2000 • 32 citations

Gene transfer to the brain: emerging therapeutic strategy in psychiatry?

1999 • 30 citations

Nongenomic effects of steroids on the nicotinic acetylcholine receptor

2000 • 26 citations

Pharmacological Characterisation of Cortical γ-Aminobutyric Acid Type A (GABA_A) Receptors in Two Wistar Rat Lines Selectively Bred for High and Low Anxiety-Related Behaviour

2000 • 15 citations