Signal Transduction Pathways Activated by RET Oncoproteins in PC12 Pheochromocytoma Cells

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

1996 • 1,170 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

Expression of the c-ret proto-oncogene during mouse embryogenesis

1993 • 831 citations

Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

1995 • 826 citations

GDNF signalling through the Ret receptor tyrosine kinase

1996 • 809 citations

Functional receptor for GDNF encoded by the c-ret proto-oncogene

1996 • 795 citations

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

1997 • 397 citations

Mechanism of Activation of the ret Proto-oncogene by Multiple Endocrine Neoplasia 2A Mutations

1995 • 336 citations

Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase

1997 • 300 citations

Molecular Characterization of a Thyroid Tumor-Specific Transforming Sequence Formed by the Fusion of ret Tyrosine Kinase and the Regulatory Subunit RIα of Cyclic AMP-Dependent Protein Kinase A

1993 • 239 citations

The ret proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas.

1990 • 233 citations

Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues.

1995 • 226 citations

Mutations of theRET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and Hirschsprung disease

1997 • 210 citations

The Full Oncogenic Activity of Ret/ptc2 Depends on Tyrosine 539, a Docking Site for Phospholipase Cγ

1996 • 199 citations

A Mutation at Tyrosine 1062 in MEN2A-Ret and MEN2B-Ret Impairs Their Transforming Activity and Association with Shc Adaptor Proteins

1996 • 188 citations

Glial Cell Line-derived Neurotrophic Factor Signals through the RET Receptor and Activates Mitogen-activated Protein Kinase

1996 • 168 citations

Signal transduction and gene control: the cAMP pathway.

1992 • 142 citations

Molecular heterogeneity of RET loss of function in Hirschsprung's disease.

1996 • 132 citations

Mitogenic Signaling by Ret/ptc2 Requires Association with Enigma via a LIM Domain

1996 • 123 citations

Identification of Shc docking site on Ret tyrosine kinase

1997 • 117 citations

Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation.

1996 • 112 citations

Glial Cell Line-derived Neurotrophic Factor Induces Ret-mediated Lamellipodia Formation

1997 • 106 citations

The ret/PTC oncogene in papillary thyroid carcinoma.

1994 • 103 citations

An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway

1994 • 102 citations

The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins.

1994 • 101 citations

Direct Association between the Ret Receptor Tyrosine Kinase and the Src Homology 2-containing Adapter Protein Grb7

1996 • 100 citations

Distinct biological properties of two RET isoforms activated by MEN 2A and MEN 2B mutations

1997 • 90 citations

Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.

1994 • 88 citations

Leucine Zipper-mediated Dimerization Is Essential for the PTC1 Oncogenic Activity

1997 • 80 citations

Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells.

1995 • 54 citations

Regulatory elements in the promoter region of vgf, a nerve growth factor-inducible gene.

1992 • 48 citations

A potential pathogenetic mechanism for multiple endocrine neoplasia type 2 syndromes involves ret-induced impairment of terminal differentiation of neuroepithelial cells.

1996 • 39 citations

Detection of phosphorylated retTPC oncogene product in cytoplasm.

1992 • 34 citations

Characterization of the promoter region and oligomerization domain of H4 (D10S170), a gene frequently rearranged with the ret proto-oncogene.

1995 • 30 citations

Nerve growth factor stimulates GAP‐43 expression in PC12 cell clones independently of neurite outgrowth

1993 • 29 citations

Characterization of ret oncogenic activation in MEN2 inherited cancer syndromes.

1996 • 29 citations

Activated RET/PTC oncogene elicits immediate early and delayed response genes in PC12 cells.

1995 • 28 citations