Uncoupling Protein-2 Participates in Cellular Defense against Oxidative Stress in Clonal β-Cells

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

1997 • 1,647 citations

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

1997 • 1,144 citations

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues

1996 • 1,136 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

1992 • 1,128 citations

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

2000 • 1,068 citations

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

2000 • 770 citations

Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational Regulation

2001 • 472 citations

Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation

1997 • 384 citations

Hydrogen Peroxide Alters Mitochondrial Activation and Insulin Secretion in Pancreatic Beta Cells

1999 • 350 citations

Determinants of the selective toxicity of alloxan to the pancreatic B cell.

1982 • 280 citations

Streptozocin- and Alloxan-Induced H2O2 Generation and DNA Fragmentation in Pancreatic Islets: H2O2 as Mediator for DNA Fragmentation

1991 • 223 citations

Cytokines and Free Radicals as Effector Molecules in the Destruction of Pancreatic Beta Cells

1990 • 185 citations

Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes

1999 • 156 citations

Kupffer Cells Are a Dominant Site of Uncoupling Protein 2 Expression in Rat Liver

1997 • 135 citations

Interference of H₂O₂ with stimulus‐secretion coupling in mouse pancreatic β‐cells

1999 • 110 citations

Effects of Adenoviral Overexpression of Uncoupling Protein-2 and -3 on Mitochondrial Respiration in Insulinoma Cells**This work was supported by V.A. Medical Research Funds and NIH Grants DK-25295 and HD-29569.

2001 • 109 citations