SPECT Quantification of [¹²³I]Iomazenil Binding to Benzodiazepine Receptors in Nonhuman Primates: I. Kinetic Modeling of Single Bolus Experiments

A new look at the statistical model identification

1974 • 46,507 citations

A method for the solution of certain non-linear problems in least squares

1944 • 11,440 citations

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

1983 • 3,439 citations

Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method

1979 • 2,396 citations

A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography

1984 • 959 citations

Quantitative Analysis of D2 Dopamine Receptor Binding in the Living Human Brain by PET

1986 • 847 citations

Compartmental Models and Their Application

1983 • 564 citations

Development and application

1971 • 464 citations

Comparison of Bolus and Infusion Methods for Receptor Quantitation: Application to [¹⁸F]Cyclofoxy and Positron Emission Tomography

1993 • 366 citations

IN-VIVO DEMONSTRATION OF REDUCED BENZODIAZEPINE RECEPTOR BINDING IN HUMAN EPILEPTIC FOCI

1988 • 361 citations

Compartmental Analysis of [¹¹C]Flumazenil Kinetics for the Estimation of Ligand Transport Rate and Receptor Distribution Using Positron Emission Tomography

1991 • 344 citations

[123I]-2.beta.-carbomethoxy-3.beta.-(4-iodophenyl)tropane: high-affinity SPECT (single photon emission computed tomography) radiotracer of monoamine reuptake sites in brain

1991 • 240 citations

Multicompartmental Analysis of [¹¹C]-Carfentanil Binding to Opiate Receptors in Humans Measured by Positron Emission Tomography

1989 • 194 citations

In vitro and in vivo evaluation of [123I]IBZM: a potential CNS D-2 dopamine receptor imaging agent.

1989 • 164 citations

In vitro and in vivo evaluation of iodine-123-Ro 16-0154: a new imaging agent for SPECT investigations of benzodiazepine receptors.

1990 • 152 citations

On the mathematical foundations of compartmental analysis in biology, medicine, and ecology

1978 • 145 citations

Comparative Penetration of Glycopyrrolate and Atropine across the Blood—Brain and Placental Barriers in Anesthetized Dogs

1978 • 125 citations

Regional Specific Binding of [¹¹C]RO 15 1788 to Central Type Benzodiazepine Receptors in Human Brain: Quantitative Evaluation by PET

1988 • 118 citations

SPECT Quantification of [¹²³I]Iomazenil Binding to Benzodiazepine Receptors in Nonhuman Primates: II. Equilibrium Analysis of Constant Infusion Experiments and Correlation with in vitro Parameters

1994 • 104 citations

Kinetic Modeling of Receptor‐Ligand Binding Applied to Positron Emission Tomographic Studies with Neuroleptic Tracers

1987 • 98 citations

Differentiation of Radioligand Delivery and Binding in the Brain: Validation of a Two-Compartment Model for [¹¹C]Flumazenil

1991 • 94 citations

Quantification of Human Opiate Receptor Concentration and Affinity Using High and Low Specific Activity [¹¹C]Diprenorphine and Positron Emission Tomography

1991 • 94 citations

In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodine‐123 labeled RTI‐55

1992 • 84 citations

Measurement of Benzodiazepine Receptor Number and Affinity in Humans Using Tracer Kinetic Modeling, Positron Emission Tomography, and [¹¹C]Flumazenil

1993 • 78 citations

Anatomical atlas of the baboon's brain in the orbito-meatal plane used in experimental positron emission tomography

1988 • 77 citations

Brain perfusion SPECT using an annular single crystal camera: initial clinical experience.

1990 • 72 citations

The characterization of IBF as a new selective dopamine D-2 receptor imaging agent.

1990 • 52 citations

Computer-Assisted Coregistration of Multislice SPECT and MR Brain Images by Fixed External Fiducials

1993 • 38 citations

Dynamic SPECT imaging after injection of the benzodiazepine receptor ligand [123I]iomazenil in healthy human subjects

1992 • 38 citations

Single photon emission tomography measurement of benzodiazepine receptor number and affinity in primate brain: a constant infusion paradigm with [123I]iomazenil

1993 • 35 citations

SPECT imaging of the benzodiazepine receptor in non-human primate brain with [123I]Ro 16-0154

1991 • 33 citations

Use of 3-quinuclidinyl 4-iodobenzilate as a receptor binding radiotracer.

1985 • 32 citations

Quantitative in vivo analysis of benzodiazepine binding sites in the human brain using positron emission tomography

1991 • 29 citations

A simple method for the preparation of 123I and 125I labeled iodobenzodiazepines

1991 • 28 citations

AN ANATOMICAL ATLAS

1955 • 19 citations

Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT

1993 • 18 citations

SPECT Imaging of the benzodiazepine receptor: Autoradiographic comparison of receptor density and radioligand distribution

1992 • 13 citations