Protein tyrosine phosphatases as negative regulators of mitogenic signaling

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1998 • 1,180 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor

1998 • 968 citations

Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

1997 • 774 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

1992 • 593 citations

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1998 • 496 citations

Conditional Expression of the Mitogen-activated Protein Kinase (MAPK) Phosphatase MKP-1 Preferentially Inhibits p38 MAPK and Stress-activated Protein Kinase in U937 Cells

1997 • 435 citations

The Mitogen-activated Protein Kinase Phosphatases PAC1, MKP-1, and MKP-2 Have Unique Substrate Specificities and Reduced Activity in Vivo toward the ERK2 sevenmaker Mutation

1996 • 434 citations

Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling

1996 • 424 citations

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

1996 • 414 citations

The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases

1996 • 385 citations

Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.

1999 • 365 citations

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

1995 • 363 citations

The Dual Specificity Mitogen-activated Protein Kinase Phosphatase-1 and -2 Are Induced by the p42/p44MAPK Cascade

1997 • 358 citations

MKP-3, a Novel Cytosolic Protein-tyrosine Phosphatase That Exemplifies a New Class of Mitogen-activated Protein Kinase Phosphatase

1996 • 350 citations

Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1

1994 • 331 citations

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif

1998 • 313 citations

Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets.

1993 • 309 citations

The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts.

1993 • 305 citations

Protein Tyrosine Phosphatase 1B Interacts With the Activated Insulin Receptor

1996 • 293 citations

PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase

1993 • 289 citations

Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction.

1998 • 265 citations

Identification of p130^cas as a Substrate for the Cytosolic Protein Tyrosine Phosphatase PTP-PEST

1996 • 263 citations

Protein-Tyrosine Phosphatase 1B Complexes with the Insulin Receptor in Vivo and Is Tyrosine-phosphorylated in the Presence of Insulin

1997 • 252 citations

A Novel Mitogen-activated Protein Kinase Phosphatase. STRUCTURE, EXPRESSION, AND REGULATION

1995 • 233 citations

Epidermal Growth Factor Receptor and the Adaptor Protein p52^Shc Are Specific Substrates of T-Cell Protein Tyrosine Phosphatase

1998 • 226 citations

Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression

1997 • 203 citations

Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts.

1996 • 203 citations

The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase.

1993 • 203 citations

Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum.

1991 • 190 citations

Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases

1998 • 180 citations

Isolation and Characterization of a Novel Dual Specific Phosphatase, HVH2, Which Selectively Dephosphorylates the Mitogen-activated Protein Kinase

1995 • 179 citations

Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts

1992 • 176 citations

Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor

1997 • 176 citations

CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion

1997 • 170 citations

Insulin Receptor Signaling Is Augmented by Antisense Inhibition of the Protein Tyrosine Phosphatase LAR

1995 • 160 citations

The Mitogen-activated Protein Kinase Phosphatase-3 N-terminal Noncatalytic Region Is Responsible for Tight Substrate Binding and Enzymatic Specificity

1998 • 158 citations

Differential activities of protein tyrosine phosphatases in intact cells.

1993 • 155 citations

Untitled

1998 • 155 citations

Selective Down-regulation of the Insulin Receptor Signal by Protein-tyrosine Phosphatases α and ∊

1995 • 147 citations

Molecular Cloning and Functional Characterization of a Novel Mitogen-activated Protein Kinase Phosphatase, MKP-4

1997 • 146 citations

Impaired Integrin-mediated Adhesion and Signaling in Fibroblasts Expressing a Dominant-negative Mutant PTP1B

1998 • 145 citations

Effect of protein tyrosine phosphatase 1B expression on transformation by the human neu oncogene.

1992 • 143 citations

A novel dual specificity phosphatase induced by serum stimulation and heat shock.

1994 • 143 citations

Inhibitory Tyrosine Protein Kinase p50 Is Associated with Protein-tyrosine Phosphatase PTP-PEST in Hemopoietic and Non-hemopoietic Cells

1997 • 139 citations

Regulation of Fibroblast Motility by the Protein Tyrosine Phosphatase PTP-PEST

1999 • 136 citations

Protein tyrosine phosphatase 1B negatively regulates integrin signaling

1998 • 136 citations

Mitogen-activated Protein Kinase Phosphatases Inactivate Stress-activated Protein Kinase Pathways in Vivo

1997 • 132 citations

The Transmembrane Protein-tyrosine Phosphatase LAR Modulates Signaling by Multiple Receptor Tyrosine Kinases

1996 • 130 citations

Protein-tyrosine Phosphatases PTP1B and Syp Are Modulators of Insulin-stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

1997 • 127 citations

Isolation of the human genes encoding the Pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases

1998 • 123 citations

A Novel Cytoplasmic Dual Specificity Protein Tyrosine Phosphatase Implicated in Muscle and Neuronal Differentiation

1996 • 117 citations

Multiple Dual Specificity Protein Tyrosine Phosphatases Are Expressed and Regulated Differentially in Liver Cell Lines

1995 • 117 citations

Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis.

1998 • 117 citations

PDGF receptor as a specific in vivo target for low M_r phosphotyrosine protein phosphatase

1995 • 106 citations

Insulin receptor protein-tyrosine phosphatases. Leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domain.

1992 • 106 citations

Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of Rat-1 fibroblasts and promotes differentiation of K562 cells

1998 • 100 citations

Functional Association between the Insulin Receptor and the Transmembrane Protein-tyrosine Phosphatase LAR in Intact Cells

1997 • 100 citations

Effect of Microinjection of a Low-M_r Human Placenta Protein Tyrosine Phosphatase on Induction of Meiotic Cell Division in Xenopus Oocytes

1990 • 99 citations

Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B.

1993 • 99 citations

Insulin receptor-associated protein tyrosine phosphatase(s): role in insulin action.

1998 • 88 citations

The Src and Signal Transducers and Activators of Transcription Pathways As Specific Targets for Low Molecular Weight Phosphotyrosine-protein Phosphatase in Platelet-derived Growth Factor Signaling

1998 • 83 citations

Adhesion through the Interaction of Lymphocyte Function-associated Antigen-1 with Intracellular Adhesion Molecule-1 Induces Tyrosine Phosphorylation of p130 and Its Association with c-CrkII

1996 • 81 citations

Ornithine Decarboxylase- and ras-Induced Cell Transformations: Reversal by Protein Tyrosine Kinase Inhibitors and Role of pp130^CAS

1995 • 81 citations

Phosphotyrosine-independent Binding of SHC to the NPLH Sequence of Murine Protein-tyrosine Phosphatase-PEST

1996 • 78 citations

Untitled

1998 • 78 citations

Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR.

1996 • 75 citations

Transformation Suppression by Protein Tyrosine Phosphatase 1B Requires a Functional SH3 Ligand

1998 • 72 citations

Sequence Requirements for Association of Protein-tyrosine Phosphatase PEP with the Src Homology 3 Domain of Inhibitory Tyrosine Protein Kinase p50

1998 • 69 citations

Calcium-dependent Signaling Pathways in T Cells

1997 • 68 citations

Isolation and characterisation of a uniquely regulated threonine, tyrosine phosphatase (TYP 1) which inactivates ERK2 and p54jnk.

1995 • 65 citations

Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase.

1994 • 62 citations

pp60v-arc Phosphorylates and Activates Low Molecular Weight Phosphotyrosine-protein Phosphatase

1996 • 61 citations

Overexpression of a synthetic phosphotyrosine protein phosphatase gene inhibits normal and transformed cell growth

1992 • 61 citations

Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes.

1990 • 60 citations

The transmembrane protein tyrosine phosphatase α dephosphorylates the insulin receptor in intact cells

1997 • 60 citations

Rapid deactivation of MAP kinase in PC12 cells occurs independently of induction of phosphatase MKP‐1

1994 • 59 citations

cDNA Cloning and Characterization of a Novel Receptor-type Protein Tyrosine Phosphatase Expressed Predominantly in the Brain

1995 • 58 citations

Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases

1995 • 56 citations

Regulation of Integrin-mediated p130Cas Tyrosine Phosphorylation in Human B Cells

1997 • 56 citations

Inhibition of cellular response to platelet‐derived growth factor by low M_r phosphotyrosine protein phosphatase overexpression

1994 • 56 citations

Low Molecular Weight Protein-tyrosine Phosphatase Tyrosine Phosphorylation by c-Src during Platelet-derived Growth Factor-induced Mitogenesis Correlates with Its Subcellular Targeting

1998 • 54 citations

A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain

1995 • 51 citations

Suppression of insulin receptor activation by overexpression of the protein-tyrosine phosphatase LAR in hepatoma cells

1996 • 49 citations

A Novel Putative Protein-tyrosine Phosphatase Contains a BRO1-like Domain and Suppresses Ha-ras-mediated Transformation

1998 • 48 citations

Suppression of v-fms-induced transformation by overexpression of a truncated T-cell protein tyrosine phosphatase.

1993 • 48 citations

Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase

1995 • 47 citations

Negative growth control by a novel lowM_rphosphotyrosine protein phosphatase in normal and transformed cells

1993 • 46 citations

A novel human ERK phosphatase regulates H-ras and v-raf signal transduction

1997 • 44 citations

The Protein Tyrosine Phosphatase LAR Has a Major Impact on Insulin Receptor Dephosphorylation

1997 • 42 citations

LowMrPhosphotyrosine Protein Phosphatase Interacts with the PDGF Receptor Directly via Its Catalytic Site

1996 • 42 citations

LAR‐PTPase cDNA transfection suppression of tumor growth of neu oncogene‐transformed human breast carcinoma cells

1995 • 21 citations