beta IFN- Interferes with the Differentiation of Dendritic Cells from Peripheral Blood Mononuclear Cells: Selective Inhibition of CD40-Dependent Interleukin-12 Secretion

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Generation of mature dendritic cells from human blood An improved method with special regard to clinical applicability

1996 • 1,138 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Interferon beta‐lb in the treatment of multiple sclerosis

1995 • 899 citations

Cytokine therapeutics: lessons from interferonalpha.

1994 • 703 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

Type I IFNs Enhance the Terminal Differentiation of Dendritic Cells

1998 • 610 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

Transforming Growth Factor β1, in the Presence of Granulocyte/Macrophage Colony-stimulating Factor and Interleukin 4, Induces Differentiation of Human Peripheral Blood Monocytes into Dendritic Langerhans Cells

1998 • 507 citations

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

1996 • 492 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway.

1997 • 443 citations

Measles Virus Suppresses Cell-mediated Immunity by Interfering with the Survival and Functions of Dendritic and T Cells

1997 • 431 citations

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones.

1992 • 430 citations

Activation and function of natural killer cell responses during viral infections

1997 • 430 citations

Dendritic cells: from ontogenetic orphans to myelomonocytic descendants

1996 • 324 citations

Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4⁺T cells via CD40 ligand

1997 • 313 citations

Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development.

1996 • 313 citations

The neglected role of type I interferon in the T-cell response: implications for its clinical use

1996 • 306 citations

Interferon-α/β inhibition of interleukin 12 and interferon-γ productionin vitroand endogenously during viral infection

1997 • 303 citations

Cloning of TRAP, a ligand for CD40 on human T cells

1992 • 280 citations

Type I IFNs Inhibit Human Dendritic Cell IL-12 Production and Th1 Cell Development

1998 • 264 citations

Interferon β decreases T cell activation and interferon γ production in multiple sclerosis

1993 • 264 citations

Interleukin‐10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin‐4 and granulocyte/ macrophage‐colony‐stimulating factor

1997 • 244 citations

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements.

1992 • 239 citations

The interferons: Biological effects, mechanisms of action, and use in multiple sclerosis

1995 • 227 citations

Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes

1996 • 212 citations

New insights into the mechanisms of interferon alfa: An immunoregulatory and anti-inflammatory cytokine

1997 • 212 citations

Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin‐10

1997 • 210 citations

Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β

1995 • 179 citations

Regulation of human peripheral blood monocyte DR antigen expression in vitro by lymphokines and recombinant interferons.

1984 • 169 citations

Recombinant interferon-alpha selectively inhibits the production of interleukin-5 by human CD4+ T cells.

1996 • 148 citations

Polyinosinic acid: polycytidylic acid promotes T helper type 1‐specific immune responses by stimulating macrophage production of interferon‐α and interleukin‐12

1995 • 137 citations

In vitro maturation of human neonatal CD4 T lymphocytes. II. Cytokines present at priming modulate the development of lymphokine production.

1994 • 126 citations

Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to class II-restricted T cells.

1995 • 125 citations

Effects of interferon-α on cytokine profile, T cell receptor repertoire and peptide reactivity of human allergen-specific T cells

1996 • 112 citations

IL-13 supports differentiation of dendritic cells from circulating precursors in concert with GM-CSF.

1995 • 111 citations

Comparative accessory cell function of human peripheral blood dendritic cells and monocytes.

1993 • 86 citations

Interferon-β specifically inhibits interferon-γ-induced class II major histocompatibility complex gene transcription in a human astrocytoma cell line

1991 • 86 citations

IFN-alpha priming of human monocytes differentially regulates gram-positive and gram-negative bacteria-induced IL-10 release and selectively enhances IL-12p70, CD80, and MHC class I expression.

1998 • 85 citations

Induction of interleukin‐12 p40 transcript by CD40 ligation via activation of nuclear factor‐xB

1997 • 79 citations

IFN-α Priming of Human Monocytes Differentially Regulates Gram-Positive and Gram-Negative Bacteria-Induced IL-10 Release and Selectively Enhances IL-12p70, CD80, and MHC Class I Expression

1998 • 71 citations

Triggering of peritoneal macrophages with IFN-alpha/beta attenuates the expression of inducible nitric oxide synthase through a decrease in NF-kappaB activation.

1998 • 66 citations

CD40 function in nonhematopoietic cells. Nuclear factor kappa B mobilization and induction of IL-6 production.

1995 • 62 citations

Anti‐interleukin 2 receptor monoclonal antibodies. Respective role of epitope mapping and monoclonal antibody‐receptor interactions in their antagonist effects on interleukin 2‐dependent T cell growth

1986 • 59 citations

Triggering of Peritoneal Macrophages with IFN-α/β Attenuates the Expression of Inducible Nitric Oxide Synthase Through a Decrease in NF-κB Activation

1998 • 57 citations

Enhancement of monocyte class I and II histocompatibility antigen expression in man by in vivo beta-interferon.

1987 • 48 citations

Role of B70/B7-2 in CD4+ T-cell immune responses induced by dendritic cells.

1995 • 34 citations

Dendritic Cells Generated from Human Blood in Granulocyte Macrophage-Colony Stimulating Factor and Interleukin-7

1997 • 32 citations

Role of cyclic AMP and polypeptide growth regulators in growth inhibition by interferon in PC‐3 cells

1991 • 23 citations

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