Hepatic toxicity and uroporphyrinogen decarboxylase activity following a single dose of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin to mice

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states

1969 • 425 citations

The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs

1978 • 387 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase Activity

1974 • 326 citations

Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition.

1975 • 303 citations

Aryl Hydrocarbon Hydroxylase Induction by Polycyclic Hydrocarbons: Simple Autosomal Dominant Trait in the Mouse

1972 • 213 citations

The genetics of aryl hydrocarbon hydroxylase induction in mice: A single gene difference between C57BL/6J and DBA/2J

1972 • 184 citations

Familial and sporadic porphyria cutanea

1978 • 181 citations

Computer Programming in Quantitative Biology

1971 • 178 citations

Nervous and Biochemical Disturbances Following Hexachlorobenzene Intoxication

1961 • 177 citations

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57B16 mice

1974 • 152 citations

The Genetic and Developmental Regulation of Hepatic δ-Aminolevulinate Dehydratase in Mice

1969 • 115 citations

Iron Deficiency Prevents Liver Toxicity of 2,3,7,8-Tetrachlorodibenzo- p -Dioxin

1979 • 110 citations

Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse.

1977 • 109 citations

Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1973 • 106 citations

Dependence of the porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo(p)dioxin upon inheritance of aryl hydrocarbon hydroxylase responsiveness

1980 • 104 citations

Effect of alteration of rat hepatic mixed-function oxidase (MFO) activity on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1978 • 90 citations

The scientific basis of toxicity assessment

1980 • 82 citations

Chlorodioxins—Origin and Fate

1973 • 81 citations

Drugs and the Hepatic Porphyrias

1980 • 75 citations

Investigations of rat liver uroporphyrinogen decarboxylase. Comparisons of porphyrinogens I and III as substrates and the inhibition by porphyrins

1981 • 64 citations

Metabolic stability of 2, 3, 7, 8-tetrachlorodibenzo-P-dioxin in mammalian liver microsomal systems and in living mice

1973 • 63 citations

Different patterns of hepatic microsomal enzyme activity produced by administration of pure hexachlorobiphenyl isomers and hexachlorobenzene

1976 • 62 citations

Decarboxylation of porphyrinogens by rat liver uroporphyrinogen decarboxylase

1979 • 55 citations

Pathological changes in the liver of mice given 2,3,7,8-tetrachlorodibenzo-p-dioxin

1975 • 46 citations

Porphyrogenic effect of chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin in female rats. Dose-effect relationship following urinary excretion of porphyrins

1981 • 45 citations

Increased inhibition of hepatic uroporphyrinogen decarboxylase by hexachlorobenzene in male rats given the oestrogenic drugs diethylstilboestrol and chlorotrianisene

1981 • 24 citations

THE TOXICOLOGY OF 2,3,7,8-TETRACHLORODIBENZO- <italic>p</italic> -DIOXIN AND ITS STRUCTURAL ANALOGUES

1979 • 15 citations