Pathogenesis in Menstrual Cycle‐Linked CNS Disorders

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

Neuroactive steroids

1992 • 1,260 citations

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

1991 • 943 citations

Non-genomic and genomic effects of steroids on neural activity

1991 • 731 citations

Differential Behavioral Effects of Gonadal Steroids in Women with and in Those without Premenstrual Syndrome

1998 • 709 citations

Increased anxiety of mice lacking the serotonin _1A receptor

1998 • 684 citations

Estradiol Increases the Sensitivity of Hippocampal CA1 Pyramidal Cells to NMDA Receptor-Mediated Synaptic Input: Correlation with Dendritic Spine Density

1997 • 679 citations

GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid

1998 • 568 citations

Modulation of the GABA receptor complex by a steroid anaesthetic

1984 • 496 citations

Three Patterns of Catamenial Epilepsy

1997 • 459 citations

Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor

1991 • 454 citations

Role of brain allopregnanolone in the plasticity of γ-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery

1998 • 410 citations

EPILEPTIC SEIZURES IN WOMEN RELATED to PLASMA ESTROGEN and PROGESTERONE DURING the MENSTRUAL CYCLE

1976 • 387 citations

Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one.

1996 • 334 citations

The role of estrogens in catamenial exacerbation of epilepsy

1959 • 279 citations

Estrogen Receptor β (ERβ) Messenger Ribonucleic Acid (mRNA) Expression within the Human Forebrain: Distinct Distribution Pattern to ERα mRNA1

2000 • 272 citations

Progesterone, 5α-pregnane-3,20-dione and 3α-hydroxy-5α-pregnane-20-one in specific regions of the human female brain in different endocrine states

1997 • 269 citations

The Premenstrual Syndrome

1984 • 269 citations

Short-term exposure to a neuroactive steroid increases α4 GABAA receptor subunit levels in association with increased anxiety in the female rat

2001 • 242 citations

The Gonad-Brain Relationship: Effects of Female Sex Hormones on Electroshock Convulsions in the Rat

1962 • 232 citations

The benzodiazepine withdrawal syndrome

1994 • 209 citations

Radioimmunoassay of 3α-hydroxy-5α-pregnan-20-one in rat and human plasma

1990 • 204 citations

Estradiol and testosterone in specific regions of the human female brain in different endocrine states

1995 • 202 citations

CYCLICAL MOOD CHANGES AS IN THE PREMENSTRUAL TENSION SYNDROME DURING SEQUENTIAL ESTROGEN‐PROGESTAGEN POSTMENOPAUSAL REPLACEMENT THERAPY

1985 • 197 citations

Allopregnanolone inhibits learning in the Morris water maze

2002 • 190 citations

Genetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety.

2000 • 184 citations

Patients with Premenstrual Syndrome Have a Different Sensitivity to a Neuroactive Steroid during the Menstrual Cycle Compared to Control Subjects

1998 • 179 citations

Acute tryptophan depletion aggravates premenstrual syndrome

1994 • 174 citations

CATAMENIAL EPILEPSY

1956 • 167 citations

The Role of Hormones and Hormonal Treatments in Premenstrual Syndrome

2003 • 167 citations

Induced Anovulation As Treatment Of Premenstrual Tension Syndrome: A double‐blind cross‐over study with GnRH‐agonist versus placebo

1988 • 160 citations

Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha- pregnan-20-one

1996 • 153 citations

Genetic Inactivation of the Serotonin_1AReceptor in Mice Results in Downregulation of Major GABA_AReceptor α Subunits, Reduction of GABA_AReceptor Binding, and Benzodiazepine-Resistant Anxiety

2000 • 153 citations

Mood changes and menstrual symptoms with different gestagen/estrogen combinations. A double blind comparison with a placebo.

1972 • 143 citations

Reduced benzodiazepine sensitivity in patients with premenstrual syndrome: A pilot study

1997 • 130 citations

“Menstrual” Migraine: Towards a Definition

1996 • 128 citations

Patients with Premenstrual Syndrome Have Reduced Sensitivity to Midazolam Compared to Control Subjects

1997 • 128 citations

Relationship Between Symptom Severity and Hormone Changes in Women With Premenstrual Syndrome*

1989 • 127 citations

Anticonvulsant and behavioral effects of neuroactive steroids alone and in conjunction with diazepam.

1997 • 126 citations

The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex

1987 • 121 citations

Prevalence of menstrual cycle symptom cyclicity and premenstrual dysphoric disorder in a random sample of women using and not using oral contraceptives

2000 • 118 citations

Spontaneous anovulation causing disappearance of cyclical symptoms in women with the premenstrual syndrome

1991 • 117 citations

Alcohol, allopregnanolone and aggression in mice

2000 • 108 citations

Pregnanolone emulsion A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent

1990 • 108 citations

Locally applied estrogens potentiate glutamate-evoked excitation of cerebellar Purkinje cells

1988 • 107 citations

Progesterone withdrawal I: pro-convulsant effects

1998 • 98 citations

Down-regulation of the GABA receptor subunits mRNA levels in mammalian cultured cortical neurons following chronic neurosteroid treatment

1996 • 97 citations

The Human Brain Has Distinct Regional Expression Patterns of Estrogen Receptor α mRNA Isoforms Derived from Alternative Promoters

2000 • 94 citations

Allopregnanolone Levels and Symptom Improvement in Severe Premenstrual Syndrome

2002 • 92 citations

Treatment of premenstrual syndrome with gonadotropin‐releasing hormone agonist in a low dose regimen

1999 • 90 citations

The Anaesthetic Potency of 3α‐Hydroxy‐5α‐pregnan‐20‐one and 3α‐Hydroxy‐5β‐pregnan‐20‐one Determined with an Intravenous EEG‐Threshold Method in Male Rats

1987 • 87 citations

Negative mood changes during hormone replacement therapy: A comparison between two progestogens

2000 • 86 citations

Estrogen Receptor (ER ) Messenger Ribonucleic Acid (mRNA) Expression within the Human Forebrain: Distinct Distribution Pattern to ER mRNA

2000 • 83 citations

Rewarding Effect of the Neuroactive Steroid 3α-hydroxy-5α-pregnan-20-one in Mice

1997 • 82 citations

Ethanol-like discriminative stimulus effects of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in femaleMacaca fascicularis monkeys

1996 • 79 citations

Alcohol, benzodiazepine-GABAA receptor complex and aggression: ethological analysis of individual differences in rodents and primates.

1993 • 74 citations

Alcohol, GABAA-Benzodiazepine Receptor Complex, and Aggression

2002 • 73 citations

Citalopram increases pregnanolone sensitivity in patients with premenstrual syndrome: An open trial

1998 • 72 citations

Increase of Estrogen Dose Deteriorates Mood during Progestin Phase in Sequential Hormonal Therapy

2003 • 69 citations

The impact of different doses of medroxyprogesterone acetate on mood symptoms in sequential hormonal therapy

2002 • 64 citations

The human corpus luteum secretes 5α-pregnane-3,20-dione

1986 • 63 citations

Neurosteroids and reward: allopregnanolone produces a conditioned place aversion in rats

2000 • 63 citations

The hyperphagic effect of 3α-hydroxylated pregnane steroids in male rats

1996 • 63 citations

Luteal-Phase Estradiol Relates to Symptom Severity in Patients with Premenstrual Syndrome¹

1998 • 61 citations

Progesterone effects during sequential hormone replacement therapy

2003 • 58 citations

Endocrinological aspects of cyclical mood changes during the menstrual cycle or the premenstrual syndrome

1983 • 55 citations

Development of Tolerance in Mice to the Sedative Effects of the Neuroactive Steroid Minaxolone Following Chronic Exposure

1997 • 53 citations

Persistence of premenstrual syndrome during low-dose administration of the progesterone antagonist RU 486.

1994 • 52 citations

Neuroactive steroids and central nervous system disorders

2001 • 48 citations

Double-blind randomized crossover trial of luteal phase estrogens (premarin®) in the premenstrual syndrome (PMS)

1990 • 47 citations

Evidence that 5α-pregnan-3α-ol-20-one is the metabolite responsible for progesterone anesthesia

1990 • 46 citations

Family History of Alcoholism in Women with Generalized Anxiety Disorder Who Have Premenstrual Syndrome: Patient Reports of Premenstrual Alcohol Consumption and Symptoms of Anxiety

1994 • 42 citations

Severe behavioral complications following intracarotid sodium amobarbital injection

1988 • 42 citations

Reported alcohol use in women with premenstrual syndrome

1994 • 40 citations

Alcohol Consumption and Menstrual Distress in Women at Higher and Lower Risk for Alcoholism

1990 • 40 citations

Exacerbation of typical absence seizures by progesterone

1992 • 38 citations

Emotional outbursts and post-traumatic stress disorder during intracarotid amobarbital procedure

2000 • 33 citations

Prevalence of menstrual cycle symptom cyclicity and premenstrual dysphoric disorder in a random sample of women using and not using oral contraceptives

2000 • 33 citations

Luteal-Phase Estradiol Relates to Symptom Severity in Patients with Premenstrual Syndrome

1998 • 32 citations

The relationship between retrospective premenstrual symptom reporting and present oral contraceptive use

1987 • 32 citations

State and trait serotonergic abnormalities in women with dysphoric premenstrual syndromes.

1997 • 30 citations

The neurosteroid 3α-hydroxy-5α-pregnan-20-one induces catalepsy in mice

1998 • 29 citations

Variability in Cyclicity Affects Pain and Other Symptoms In Female Fibromyalgia Syndrome Patients

1998 • 29 citations

Severe Negative Emotional Reactions in Intracarotid Sodium Amytal Procedures: Further Evidence For Hemispheric Asymmetries?

1991 • 29 citations

Central-nervous side effects of midazolam during transesophageal echocardiography

2002 • 28 citations

Binding of [3H]paroxetine to serotonin uptake sites and of [3H]lysergic acid diethylamide to 5-HT2A receptors in platelets from women with premenstrual dysphoric disorder during gonadotropin releasing hormone treatment

2001 • 22 citations

Neuroactive steroids exacerbate γ-hydroxybutyric acid-induced absence seizures in rats

1998 • 21 citations

Lack of influence of menstrual cycle and premenstrual syndrome diagnosis on pregnanolone pharmacokinetics

1999 • 18 citations

Menstrually Related Disorders: Points of Consensus, Debate, and Disagreement

1993 • 17 citations

The impact of different doses of medroxyprogesterone acetate on mood symptoms in sequential hormonal therapy

2002 • 2 citations