Muc-5/5ac Mucin Messenger RNA and Protein Expression Is a Marker of Goblet Cell Metaplasia in Murine Airways

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

Eosinophilic Inflammation in Asthma

1990 • 2,535 citations

Requirement for IL-13 Independently of IL-4 in Experimental Asthma

1998 • 1,869 citations

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1999 • 1,715 citations

Cellular Events in the Bronchi in Mild Asthma and after Bronchial Provocation

1989 • 1,158 citations

Epithelial Mucin Genes

1995 • 982 citations

The interaction of wheat germ agglutinin with sialoglycoproteins. The role of sialic acid.

1979 • 602 citations

Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma

1997 • 527 citations

Marked Goblet Cell Hyperplasia with Mucus Accumulation in the Airways of Patients Who Died of Severe Acute Asthma Attack

1992 • 513 citations

Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia.

1994 • 498 citations

Pulmonary macrophages

1994 • 476 citations

Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

1997 • 464 citations

Signal Transducer and Activator of Transcription Factor 6 (Stat6)-deficient Mice Are Protected from Antigen-induced Airway Hyperresponsiveness and Mucus Production

1998 • 458 citations

Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization.

1993 • 455 citations

IL-4 Induces Mucin Gene Expression and Goblet Cell Metaplasia In Vitro and In Vivo

1999 • 453 citations

Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.

1996 • 355 citations

CD4⁺T-Lymphocytes and Interleukin-5 Mediate Antigen-induced Eosinophil Infiltration into the Mouse Trachea

1992 • 353 citations

The importance of leukotrienes in airway inflammation in a mouse model of asthma.

1996 • 312 citations

A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretion.

1997 • 263 citations

Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse

1992 • 262 citations

Allergic Eosinophil-rich Inflammation Develops in Lungs and Airways of B Cell–deficient Mice

1997 • 257 citations

Requirements for Allergen-Induced Airway Hyperreactivity in T and B Cell-Deficient Mice

1998 • 243 citations

MUC5AC, but not MUC2, is a prominent mucin in respiratory secretions

1996 • 232 citations

Mucin gene (MUC 2 and MUC 5AC) upregulation by Gram-positive and Gram-negative bacteria

1998 • 228 citations

Molecular cloning and analysis of the mouse homologue of the tumor-associated mucin, MUC1, reveals conservation of potential O-glycosylation sites, transmembrane, and cytoplasmic domains and a loss of minisatellite-like polymorphism

1991 • 225 citations

Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).

1994 • 222 citations

Airway structure and inflammatory cells in fatal attacks of asthma

1996 • 214 citations

Lung inflammation and epithelial changes in a murine model of atopic asthma.

1996 • 208 citations

Mucins: structure, function, and role in pulmonary diseases

1992 • 205 citations

Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice

1997 • 205 citations

Structure and Biology of a Carcinoma-associated Mucin, MUC1

1991 • 195 citations

The cells of the tracheobronchial epithelium of the mouse: a quantitative light and electron microscope study.

1981 • 193 citations

Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response.

1997 • 185 citations

Respiratory mucins: identification of core proteins and glycoforms

1996 • 184 citations

Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals.

1986 • 178 citations

Developmental Expression of Mucin Genes in the Human Respiratory Tract

1997 • 147 citations

Expression of MUC1, MUC2, MUC3 and MUC4 mucin mrnas in human pancreatic and intestinal tumor cell lines

1994 • 145 citations

PDB2MultiGIF: A Web Tool to Create Animated Images of Molecules

1998 • 123 citations

Respiratory Carcinoma Cell Lines

1999 • 109 citations

Histochemistry of mucosubstances in the canine and human respiratory tract.

1971 • 102 citations

Human respiratory mucus.

1986 • 100 citations

Mucin gene expression in rat airways following infection and irritation

1991 • 87 citations

Model Systems for Investigating Mucin Gene Expression in Airway Diseases

2000 • 79 citations

Molecular cloning of the amino-terminal region of a rat MUC 2 mucin gene homologue. Evidence for expression in both intestine and airway.

1994 • 79 citations

Mucin mRNA Expression in Normal and Vasomotor Inferior Turbinates

1997 • 78 citations

Mouse gastric mucin: cloning and chromosomal localization

1995 • 74 citations

The relationship between airway inflammation and bronchial hyperresponsiveness

1989 • 72 citations

Molecular cloning of rat intestinal mucin. Lack of conservation between mammalian species.

1991 • 66 citations

Asthma

1994 • 58 citations

Sialomucin complex in the rat respiratory tract: a model for its role in epithelial protection

1998 • 53 citations

Proteolytic fragmentation and peptide mapping of human carboxyamidomethylated tracheobronchial mucin

1989 • 52 citations

Airway Mucin Genes and Gene Products

1997 • 50 citations

Goblet cell-specific expression mediated by theMUC2mucin gene promoter in the intestine of transgenic mice

1999 • 50 citations

Definition of pediatric asthma and associated risk factors

1997 • 47 citations

Role of Interleukin-4 in the Development of Allergic Airway Inflammation and Airway Hyperresponsiveness

1996 • 16 citations