Role of Interleukin-4 in the Development of Allergic Airway Inflammation and Airway Hyperresponsiveness

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

1988 • 976 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Identification of Activated T Lymphocytes and Eosinophils in Bronchial Biopsies in Stable Atopic Asthma

1990 • 890 citations

IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.

1992 • 838 citations

Allergic and Nonallergic Asthmatics Have Distinct Patterns of T-Cell Activation and Cytokine Production in Peripheral Blood and Bronchoalveolar Lavage

1992 • 788 citations

IL-4 is required to generate and sustain in vivo IgE responses.

1988 • 671 citations

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

1995 • 626 citations

Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor.

1988 • 619 citations

Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia.

1994 • 498 citations

Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity

1991 • 472 citations

Attenuation of allergic airway inflammation in IL‐4 deficient mice

1994 • 433 citations

Active anaphylaxis in IgE-deficient mice

1994 • 414 citations

Identification of T lymphocytes, Macrophages, and Activated Eosinophils in the Bronchial Mucosa in Intrinsic Asthma: Relationship to Symptoms and Bronchial Responsiveness

1992 • 414 citations

CD4⁺T-Lymphocytes and Interleukin-5 Mediate Antigen-induced Eosinophil Infiltration into the Mouse Trachea

1992 • 353 citations

Trial of cyclosporin in corticosteroid-dependent chronic severe asthma

1992 • 334 citations

CD4 T-Lymphocyte Activation in Acute Severe Asthma: Relationship to Disease Severity and Atopic Status

1990 • 327 citations

Local allergen challenge and bronchoalveolar lavage of allergic asthmatic lungs. Description of the model and local airway inflammation.

1987 • 321 citations

Recombinant human interleukin 5 is a selective eosinophil chemoattractant

1989 • 319 citations

Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue.

1994 • 312 citations

Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice.

1995 • 311 citations

Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils

1991 • 299 citations

Identification of T-lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma

1992 • 279 citations

Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis.

1991 • 266 citations

CD4 T-Lymphocyte Activation in Asthma Is Accompanied by Increased Serum Concentrations of Interleukin-5: Effect of Glucocorticoid Therapy

1993 • 264 citations

Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse

1992 • 262 citations

Number and activity of inflammatory cells in bronchoalveolar lavage fluid in asthma and their relation to airway responsiveness.

1988 • 196 citations

Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma.

1994 • 172 citations

Bronchoalveolar Lavage and Histologic Characterization of Late Asthmatic Response in Guinea Pigs

1987 • 152 citations

Dynamic T-Cell Changes in Peripheral Blood and Bronchoalveolar Lavage after Antigen Bronchoprovocation in Asthmatics

1991 • 122 citations

Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation.

1986 • 106 citations

Role of VLA-4 and LFA-1 in allergen-induced airway hyperresponsiveness and lung inflammation in the rat.

1995 • 78 citations

Antigen-induced Acute and Late-phase Responses in Primates

1992 • 75 citations

Role of VLA-4 and LFA-1 in Allergen-Induced Airway Hyperresponsiveness and Lung Inflammation in the Rat

1995 • 58 citations

Inflammation and Airway Function: The Asthma Syndrome

1990 • 25 citations