Role of matrix metalloproteinase‐9 in progression of mouse skin carcinogenesis

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Matrix Metalloproteinases

1999 • 3,774 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.

1993 • 704 citations

Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β

1989 • 649 citations

Matrix metalloproteinases: multifunctional contributors to tumor progression

2000 • 639 citations

Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin.

1992 • 519 citations

A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

1986 • 515 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

Oncogene Activation in Chemical Carcinogenesis

1988 • 383 citations

Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences

1996 • 351 citations

Tissue inhibitor of metalloproteinases (TIMP, aka EPA): Structure, control of expression and biological functions

1993 • 270 citations

Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades

1997 • 233 citations

Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase

1989 • 233 citations

Expression of genes encoding type IV collagen-degrading metalloproteinases and tissue inhibitors of metalloproteinases in various human tumor cells.

1992 • 228 citations

Preclinical and Clinical Studies of MMP Inhibitors in Cancer

1999 • 222 citations

Induction of collagenase secretion in human fibroblast cultures by growth promoting factors.

1985 • 186 citations

The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts

1991 • 160 citations

Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice.

1991 • 139 citations

Coordinate regulation of stromelysin and collagenase genes determined with cDNA probes.

1987 • 129 citations

Interleukin-1 beta and transforming growth factor-alpha/epidermal growth factor induce expression of M(r) 95,000 type IV collagenase/gelatinase and interstitial fibroblast-type collagenase by rat mucosal keratinocytes.

1993 • 126 citations

Positive and negative transcriptional elements of the human type IV collagenase gene.

1990 • 121 citations

Skin tumors: experimental and clinical aspects.

1989 • 101 citations

Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes.

1991 • 94 citations

High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model

2000 • 87 citations

The structure of the human skin fibroblast collagenase gene.

1988 • 78 citations

Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo

1991 • 76 citations

Involvement of a Mitogen-activated Protein Kinase Signaling Pathway in the Regulation of Urokinase Promoter Activity by c-Ha-ras

1995 • 72 citations

A switch from stromal to tumor cell expression of stromelysin‐1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression

1994 • 57 citations

Constitutive Production of Procollagenase and Tissue Inhibitor of Metalloproteinases by Human Keratinocytes in Culture

1989 • 51 citations

Altered Epidermal Growth Factor Signal Transduction in Activated Ha-ras-Transformed Human Keratinocytes

1993 • 22 citations

BINDING OF WILD-TYPE AND MUTANT FORMS OF P53 PROTEIN FROM HUMAN TUMORS TO A SPECIFIC DNA-SEQUENCE OF THE FIRST INTRON OF THE H-RAS ONCOGENE

1995 • 3 citations