Preclinical and Clinical Studies of MMP Inhibitors in Cancer

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas

1994 • 769 citations

Matrix metalloproteinase–1 is associated with poor prognosis in colorectal cancer

1996 • 449 citations

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.

1990 • 406 citations

Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors

1996 • 404 citations

Matrix metalloproteinase–1 is associated with poor prognosis in colorectal cancer

1996 • 312 citations

Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

1991 • 287 citations

Recent advances in matrix metalloproteinase inhibitor research

1996 • 279 citations

Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3.

1994 • 217 citations

Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: selection of a biologically active and tolerable dose for longer-term studies.

1998 • 211 citations

Human fibroblast collagenase: glycosylation and tissue-specific levels of enzyme synthesis.

1986 • 125 citations

Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers

1998 • 104 citations

Matrix metalloproteinase inhibitors in the treatment of cancer

1997 • 88 citations

Correlation between collagenolytic activity and grade of histological differentiation in colorectal tumors

1990 • 80 citations

Relaxed Specificity of Matrix Metalloproteinases (MMPS) and TIMP Insensitivity of Tumor Necrosis Factor-α (TNF-α) Production Suggest the Major TNF-α Converting Enzyme Is Not an MMP

1996 • 69 citations

Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor.

1997 • 61 citations

Batimastat

1996 • 16 citations

Recent advances in matrix metalloproteinase inhibitor research and development.

1998 • 12 citations

Expression of matrix metalloproteinases in colorectal cancer

1996 • 2 citations