Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

2006 • 1,802 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

2003 • 1,500 citations

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

2006 • 1,485 citations

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

2007 • 1,416 citations

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

2007 • 1,375 citations

Role of LAG-3 in Regulatory T Cells

2004 • 1,198 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

Molecular and Functional Profiling of Memory CD8 T Cell Differentiation

2002 • 962 citations

Effector and Memory CTL Differentiation

2006 • 908 citations

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 • 859 citations

Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection

2007 • 847 citations

Memory CD8 T-Cell Differentiation during Viral Infection

2004 • 841 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral Infection

2007 • 567 citations

PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

2006 • 558 citations

LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems

2007 • 509 citations

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction

2007 • 502 citations

Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade

2008 • 500 citations

Antigen-independent memory CD8 T cells do not develop during chronic viral infection

2004 • 489 citations

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

2006 • 465 citations

Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection

2007 • 415 citations

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

2006 • 396 citations

Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.

1992 • 366 citations

CD8 T cell dysfunction during chronic viral infection

2007 • 335 citations

Lymphocyte Activation Gene-3 (CD223) Regulates the Size of the Expanding T Cell Population Following Antigen Activation In Vivo

2004 • 328 citations

CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator

2008 • 323 citations

Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)

2005 • 306 citations

PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors

2007 • 293 citations

The CD4‐related molecule, LAG‐3 (CD223), regulates the expansion of activated T cells

2003 • 289 citations

Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

2007 • 260 citations

Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells

2008 • 237 citations

CD3/TCR Complex-Associated Lymphocyte Activation Gene-3 Molecules Inhibit CD3/TCR Signaling

1998 • 237 citations

Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection

2008 • 206 citations

Expression of the Interleukin-7 Receptor Alpha Chain (CD127) on Virus-Specific CD8 ⁺ T Cells Identifies Functionally and Phenotypically Defined Memory T Cells during Acute Resolving Hepatitis B Virus Infection

2006 • 191 citations

The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo

2003 • 189 citations

High viral burden in the presence of major HIV-specific CD8+ T cell expansions: evidence for impaired CTL effector function

2001 • 185 citations

A new self: MHC-class-I-independent Natural-killer-cell self-tolerance

2005 • 175 citations

Paired immunoglobulin‐like receptors and their MHC class I recognition

2005 • 164 citations

Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE.

1996 • 160 citations

IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection

2008 • 151 citations

LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination

2003 • 140 citations

Cutting Edge: Emergence of CD127high Functionally Competent Memory T Cells Is Compromised by High Viral Loads and Inadequate T Cell Help

2005 • 138 citations

Molecular Basis of the Dual Functions of 2B4 (CD244)

2008 • 135 citations

The CD8⁺T-Cell Response to Lymphocytic Choriomeningitis Virus Involves the L Antigen: Uncovering New Tricks for an Old Virus

2007 • 115 citations

Low CD8 T-Cell Proliferative Potential and High Viral Load Limit the Effectiveness of Therapeutic Vaccination

2005 • 110 citations

Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells

1997 • 104 citations

2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells

2004 • 97 citations

Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells.

1997 • 90 citations

Proliferation of activated CD1d‐restricted NKT cells is down‐modulated by lymphocyte activation gene‐3 signaling via cell cycle arrest in S phase

2006 • 43 citations

Cutting Edge: Distinct NK Receptor Profiles Are Imprinted on CD8 T Cells in the Mucosa and Periphery during the Same Antigen Challenge: Role of Tissue-Specific Factors

2007 • 28 citations