Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

A physiological approach to hepatic drug clearance

1975 • 1,855 citations

Quantitative Relations in the Physiological Constitutions of Mammals

1949 • 497 citations

Methotrexate Pharmacokinetics

1971 • 481 citations

Metabolic Activation of Drugs to Toxic Substances

1975 • 281 citations

The fate of antipyrine in man.

1950 • 215 citations

Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat.

1976 • 211 citations

The Effect of Disease States on Drug Pharmacokinetics

1977 • 155 citations

Dose-dependence of drug plasma level decline in dogs.

1967 • 98 citations

Pharmacokinetic Profiles of Clonazepam in Dog and Humans and of Flunitrazepam in Dog

1974 • 78 citations

Pharmacokinetics of the anticonvulsant drug clonazepam evaluated from single oral and intravenous doses and by repeated oral administration

1975 • 72 citations

Influence of acute viral hepatitis on phenytoin kinetics and protein binding

1975 • 66 citations

Metabolism of Drugs. LXX. Further Study on Antipyrine Metabolism

1971 • 60 citations

Metabolism of Drugs

1964 • 58 citations

Metabolism of drugs—LIX

1968 • 56 citations

Early role during chemical evolution for cytochrome P450 in oxygen detoxification

1975 • 50 citations

Biopharmaceutical and clinical pharmacokinetic profile of bromazepam

1976 • 48 citations

Norphenazone, a new metabolite of phenazone in human urine

1973 • 43 citations

Comparative Drug Metabolism

1969 • 43 citations

Pharmacokinetic and biopharmaceutic profile of chlordiazepoxide HCl in healthy subjects: Single-dose studies by the intravenous, intramuscular, and oral routes

1977 • 41 citations

Metabolites of Bromazepam, a Benzodiazepine, in the Human, Dog, Rat, and Mouse

1973 • 38 citations

Dependence of pharmacokinetic parameters on the body weight.

1977 • 37 citations

¹⁴C‐Antipyrine as a Model Compound in the Study of Drug Oxidation and Enzyme Induction in Individual Surviving Rats

1974 • 36 citations

The role of substituents in the hydrophobic binding of the 1,4-benzodiazepines by human plasma proteins.

1976 • 32 citations

Pharmacokinetic Model for Chlordiazepoxide·HCl in the Dog

1970 • 28 citations

Intraindividual Relationships between Serum Protein Binding of Drugs in Normal Human Subjects, Patients with Impaired Renal Function, and Rats

1977 • 25 citations

Effect of an Inhibitor of Glucuronide Formation on Elimination Kinetics of Diphenylhydantoin in Rats

1973 • 24 citations

Placental transfer of diphenylhydantoin in the goat

1972 • 22 citations

Influence of phenobarbital on the disposition of clonazepam and antipyrine in the dog

1977 • 16 citations

Improved Microdetermination for Diphenylhydantoin in Blood by UV Spectrophotometry

1973 • 14 citations

Comparative study of plasma protein binding of diphenylhydantoin

1973 • 14 citations

Metabolism of antipyrine by the epoxide-diol pathway in the rat, guinea pig and human.

1974 • 10 citations

Studies on Metabolism of Bromazepam. V. Identification of New Urinary Metabolites and Their Excretion Pattern in Various Animal Species

1975 • 6 citations

Possible Similar Role of Cytochrome P450 in Primordial Evolution of Species and in Chemical Carcinogenesis

1976 • 4 citations

9 ~ Storage and Protection of Genetic Variation

1963 • 2 citations