Comparative Drug Metabolism

Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines.

1953 • 1,702 citations

The Kidney: Structure and Function in Health and Disease

1952 • 1,326 citations

Fortschritte der Arzneimittelforschung

1960 • 669 citations

Enzymatic Metabolism of Drugs and other Foreign Compounds

1958 • 501 citations

Quantitative Relations in the Physiological Constitutions of Mammals

1949 • 497 citations

EFFECT OF DRUGS ON THE FORMATION OF SMOOTH ENDOPLASMIC RETICULUM AND DRUG‐METABOLIZING ENZYMES

1965 • 381 citations

Species, strain and sex differences in metabolism of hexobarbitone, amidopyrine, antipyrine and aniline

1958 • 372 citations

Basal Metabolism in Health and Disease

1927 • 322 citations

The Biochemistry of Foreign Compounds

1968 • 302 citations

Studies of the enzymatic deamination of cytosine arabinoside—I

1965 • 296 citations

The enzymatic metabolism of hexobarbital (evipal).

1955 • 295 citations

The use of body surface area as a criterion of drug dosage in cancer chemotherapy.

1958 • 291 citations

The biochemistry of foreign compounds

1968 • 263 citations

Factors Influencing Drug Metabolism

1962 • 258 citations

Detoxication of Drugs and Other Foreign Compounds by Liver Microsomes

1955 • 255 citations

Regression Lines and the Linear Functional Relationship

1947 • 243 citations

The metabolic fate of tritiated methotrexate. II. Absorption and excretion in man.

1965 • 223 citations

CLINICAL STUDIES OF THE BLOOD VOLUME. II. THE RELATION OF PLASMA AND TOTAL BLOOD VOLUME TO VENOUS PRESSURE, BLOOD VELOCITY RATE, PHYSICAL MEASUREMENTS, AGE AND SEX IN NINETY NORMAL HUMANS

1937 • 221 citations

Biogenesis of Natural Compounds

1963 • 212 citations

SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES.

1964 • 186 citations

The Pharmacological Basis of Therapeutics

1966 • 185 citations

SIMPLIFICATION OF DRUG DOSAGE CALCULATION BY APPLICATION OF THE SURFACE AREA PRINCIPLE

1950 • 166 citations

Absorption, distribution and excretion of amantadine hydrochloride.

1965 • 164 citations

Physiological disposition and fate of chlorpromazine and a method for its estimation in biological material.

1956 • 154 citations

Studies in detoxication. 86. The metabolism of 14C-labelled ethylene glycol

1961 • 137 citations

Enzymatic reduction of prontosil and other azo dyes.

1957 • 136 citations

The metabolic fate of tritiated methotrexate. I. Absorption, excretion, and distribution in mice, rats, dogs and monkeys.

1965 • 123 citations

The metabolism of drugs by liver microsomes from alloxan-diabetic rats.

1961 • 116 citations

Studies in detoxication. 84. The metabolism of [14C]aniline in the rabbit and other animals

1960 • 104 citations

The biochemistry of aromatic amines. 2. The conversion of arylamines into arylsulphamic acids and arylamine-N-glucosiduronic acids

1957 • 103 citations

Basal Metabolism in Health and Disease

1936 • 93 citations

The fate of procaine in man following its intravenous administration and methods for the estimation of procaine and diethylaminoethanol.

1948 • 90 citations

Homeostatic Limits to Safe Parenteral Fluid Therapy

1953 • 88 citations

HEPATIC DRUG METABOLISM DURING THE PERINATAL PERIOD

1965 • 87 citations

The influence of various factors on the enzymatic conversion of organic thiophosphates to anticholinesterase agents.

1958 • 86 citations

Mechanisms of Drug Absorption and Excretion

1964 • 71 citations

Factors influencing steroid hydroxylases in liver microsomes

1966 • 69 citations

The Comparative Physiological Disposition of ThioTEPA and TEPA in the Dog

1960 • 65 citations

Enzymatic oxidation of pentobarbital and thiopental.

1957 • 61 citations

The Metabolic Fate of Drugs

1964 • 56 citations

Comparative biochemistry of drug metabolism by azo and nitro reductase.

1965 • 56 citations

Kinetic studies of the metabolism of foreign organic compounds. 4. The conjugation of phenols with sulphuric acid

1952 • 54 citations

The Distribution in the Body and Metabolic Fate of Barbiturates

1954 • 50 citations

Species differences and the clinical trial of new drugs: A review

1966 • 46 citations

Ueber Verwandlung der Benzoësäure in Hippursäure

1842 • 45 citations

PHYSIOLOGICAL VARIATIONS IN THE CARDIAC OUTPUT OF MAN

1929 • 40 citations

Progress in Drug Research.

1963 • 40 citations

DRUG TOXICITY AS A RESULT OF INTERFERENCE WITH PHYSIOLOGICAL CONTROL MECHANISMS

1965 • 40 citations

III. The blood volume of mammals as determined by experiments upon rabbits, guinea-pigs, and mice; and its relationship to the body weight and to the surface area expressed in formula

1911 • 39 citations

Comparative detoxication. 13. Detoxication of aromatic acids in arachnids: arginine, glutamic acid and glutamine conjugations

1964 • 37 citations

Metabolic studies of 32P-labelled triethylenethiophosphoramide

1959 • 37 citations

Comparative Biochemistry

1964 • 36 citations

Distribution and Excretion of Radioactivity after Administration of Morphine-N-methyl C14 to Rats.

1954 • 33 citations

Detoxication mechanisms in man

1963 • 32 citations

Excretion of Carbon-14 by Man after Administration of Morphine-N-Methyl-C14

1954 • 31 citations

Comparative Biochemistry of Detoxification

1964 • 30 citations

THE ROLE OF ACTIVATING AND DEGRADING ENZYMES IN DETERMINING SPECIES SPECIFICITY OF TOXICANTS

1965 • 28 citations

The metabolism and excretion of S35-chlorpromazine by the rat.

1962 • 26 citations

Absorption and fate of C14-labeled N,N',N''-triethylenethiophosphoramide (thio-TEPA) in humans and dogs.

1962 • 24 citations

Metabolic Fate of Drugs: Barbiturates and Closely Related Compounds

1967 • 23 citations

Conjugation and excretion of the amino and acetamido benzoic acids

1959 • 20 citations

VI. Further experiments upon the blood volume of mammals and its relation to the surface area of the body

1912 • 20 citations

Toxicologic studies on hydrocarbons

1966 • 20 citations

Plasma levels, urinary and fecal excretion of morphine in non-tolerant and tolerant dogs.

1954 • 19 citations

Plasma levels and excretion of codeine and metabolites in the dog and monkey.

1956 • 19 citations

Studies on OPSPA. IV. Metabolism of OPSPA in the rat and human.

1957 • 18 citations

Genetic Factors in Relation to Drugs

1965 • 18 citations

Kinetic studies on the metabolism of foreign organic compounds. 6. Reactions of some nuclear-substituted benzoic acids, benzamides and toluenes in the rabbit

1955 • 18 citations

PLASMA VOLUME, “AVAILABLE (THIOCYANATE) VOLUME” AND TOTAL CIRCULATING PLASMA PROTEINS IN NORMAL ADULTS

1945 • 18 citations

The distribution and fate of morphine in the non-tolerant and tolerant monkey.

1956 • 18 citations

In vivo Formation of Normorphine in the Rat as a Metabolite of Tritium Nuclear-labelled Morphine

1961 • 14 citations

The synthesis and estimation of N-C14-methyl labeled levorphanol and its biological disposition in the monkey, dog and rat.

1958 • 11 citations

Conference on Nonhuman Primate Toxicology

1970 • 11 citations

Toxic Fluorine Compounds. VI.¹ ι-Fluoroalkylamines

1956 • 9 citations

Excretion of Urinary N-C14-Methyl Morphine and Pulmonary C14O2 in the Monkey and Dog after Subcutaneous Injection of the Labelled Drug.

1961 • 8 citations

FUNDAMENTAL ASPECTS OF SELECTIVE TOXICITY

1965 • 8 citations