TIMP-1 inhibits microvascular endothelial cell migration by MMP-dependent and MMP-independent mechanisms
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References (52)
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
2002 • 2,711 citations
Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3
1996 • 1,555 citations
Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.
1997 • 1,510 citations
A causal role for E-cadherin in the transition from adenoma to carcinoma
1998 • 1,415 citations
Focal adhesion kinase: the first ten years
2003 • 1,360 citations
FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
2004 • 1,330 citations
Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN
1998 • 1,215 citations
Metalloproteinase inhibitors: biological actions and therapeutic opportunities
2002 • 1,159 citations
Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again
2002 • 741 citations
Growth‐promoting activity of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) for a wide range of cells A possible new growth factor in serum
1992 • 705 citations
The biology of PECAM-1.
1997 • 669 citations
A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2
2003 • 643 citations
TIMP-2 Mediated Inhibition of Angiogenesis
2003 • 494 citations
Complex roles of tissue inhibitors of metalloproteinases in cancer
2002 • 472 citations
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis
2001 • 471 citations
Focal adhesion kinase (p125FAK): A point of convergence in the action of neuropeptides, integrins, and oncogenes
1992 • 453 citations
Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten
1999 • 418 citations
Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors
1996 • 404 citations
Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor α, interleukin 1 and phorbol ester
1993 • 388 citations
Tissue inhibitor of metalloproteinases‐2 inhibits bFGF‐induced human microvascular endothelial cell proliferation
1993 • 362 citations
Three-dimensional Type I Collagen Lattices Induce Coordinate Expression of Matrix Metalloproteinases MT1-MMP and MMP-2 in Microvascular Endothelial Cells
1998 • 358 citations
Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.
1995 • 341 citations
Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN
2004 • 338 citations
Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.
1988 • 312 citations
Inhibition of angiogenesis by tissue inhibitor of metalloproteinase
1994 • 299 citations
Human endothelial gelatinases and angiogenesis
2001 • 294 citations
Cleavage of β-Catenin and Plakoglobin and Shedding of VE-Cadherin during Endothelial Apoptosis: Evidence for a Role for Caspases and Metalloproteinases
1998 • 264 citations
Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo
2000 • 264 citations
Focal adhesion kinase: at the crossroads of signal transduction
1997 • 260 citations
Growth Stimulation of Human Keratinocytes by Tissue Inhibitor of Metalloproteinases
1991 • 241 citations
Vascular Endothelial (VE)-Cadherin: Only an Intercellular Glue?
1999 • 238 citations
Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs)
2002 • 238 citations
Interendothelial junctions: structure, signalling and functional roles
1997 • 219 citations
Vascular-endothelial-cadherin modulates endothelial monolayer permeability
1999 • 209 citations
Integrin-linked Kinase (ILK) Binding to Paxillin LD1 Motif Regulates ILK Localization to Focal Adhesions
2001 • 208 citations
Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration.
2001 • 198 citations
MMP-2 Colocalizes with Caveolae on the Surface of Endothelial Cells
2001 • 171 citations
Interendothelial Junctions and their Role in the Control of Angiogenesis, Vascular Permeability and Leukocyte Transmigration
2001 • 163 citations
Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2)
1990 • 154 citations
Integration of Cell Attachment, Cytoskeletal Localization, and Signaling by Integrin-linked Kinase (ILK), CH-ILKBP, and the Tumor Suppressor PTEN
2003 • 136 citations
Matrix Metalloproteinase-9 Silencing by RNA Interference Triggers the Migratory-adhesive Switch in Ewing's Sarcoma Cells
2003 • 124 citations
Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN
2001 • 118 citations
Tissue inhibitor of metalloproteinases-1 (TIMP-1) inhibits tumor growth and angiogenesis in the TIMP-1 transgenic mouse model
2003 • 108 citations
Tissue inhibitor of metalloproteinase 1 is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo.
1993 • 108 citations
Structural and Functional Uncoupling of the Enzymatic and Angiogenic Inhibitory Activities of Tissue Inhibitor of Metalloproteinase-2 (TIMP-2)
2003 • 106 citations
Tissue inhibitor of metalloprotease (TIMP)‐1 and proliferative behaviour of clonal breast cancer cells
1999 • 94 citations
Platelet endothelial cell adhesion molecule‐1 modulates endothelial cell motility through the small G‐protein Rho
2003 • 78 citations
MMP Inhibitors Augment Fibroblast Adhesion through Stabilization of Focal Adhesion Contacts and Up-regulation of Cadherin Function
2001 • 66 citations
TIMP-4 Is Regulated by Vascular Injury in Rats
1999 • 66 citations
MT1‐MMP, but not secreted MMPs, influences the migration of human microvascular endothelial cells in 3‐dimensional collagen gels
2002 • 58 citations
Matrix metalloproteinase(s) mediate(s) NO-induced dissociation of beta-catenin from membrane bound E-cadherin and formation of nuclear beta-catenin/LEF-1 complex
2002 • 53 citations
Role of PTEN and MMP‐7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma
2003 • 51 citations