Myocardial Gene Expression in Dilated Cardiomyopathy Treated with Beta-Blocking Agents

Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling

2000 • 2,460 citations

β-Adrenergic Receptor Blockade in Chronic Heart Failure

2000 • 1,020 citations

Time course of improvement in left ventricular function, mass and geometry in patients with congestive heart failure treated with beta-adrenergic blockade

1995 • 544 citations

Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium.

1997 • 493 citations

Medical Therapy Can Improve the Biological Properties of the Chronically Failing Heart

1996 • 468 citations

Comparative Hemodynamic, Left Ventricular Functional, and Antiadrenergic Effects of Chronic Treatment With Metoprolol Versus Carvedilol in the Failing Heart

1996 • 455 citations

Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure

1993 • 423 citations

Left Ventricular Remodeling With Carvedilol in Patients With Congestive Heart Failure Due to Ischemic Heart Disease fn1fn1This study was funded by a grant from SmithKline Beecham; however, the study was initiated, conducted, analyzed and reported by the Australia–New Zealand Heart Failure Research Collaborative Group independently of the sponsor. The Clinical Trials Research Unit is supported by a programme grant from the Health Research Council of New Zealand.

1997 • 416 citations

Differential Effects of β-Blockers in Patients With Heart Failure

2000 • 342 citations

Molecular and Cellular Mechanisms of Myocardial Failure

1997 • 328 citations

Effects of carvedilol on left ventricular mass, chamber geometry, and mitral regurgitation in chronic heart failure

1999 • 314 citations

Dose-response of chronic beta-blocker treatment in heart failure from either idiopathic dilated or ischemic cardiomyopathy. Bucindolol Investigators.

1994 • 280 citations

Prognostic significance of serial changes in left ventricular ejection fraction in patients with congestive heart failure

1993 • 256 citations

Mechanism of Action of Beta-Blocking Agents in Heart Failure

1997 • 254 citations

Management of Heart Failure

2015 • 236 citations

Beta-blockade with bucindolol in heart failure caused by ischemic versus idiopathic dilated cardiomyopathy.

1991 • 232 citations

Selective gene expression in failing human heart. Quantification of steady-state levels of messenger RNA in endomyocardial biopsies using the polymerase chain reaction.

1991 • 199 citations

Why does the myocardium fail? Insights from basic science

1998 • 177 citations

Reversible alterations in myocardial gene expression in a young man with dilated cardiomyopathy and hypothyroidism.

1992 • 177 citations

Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart

1995 • 138 citations

Analysis of beta-adrenergic receptor mRNA levels in human ventricular biopsy specimens by quantitative polymerase chain reactions: Progressive reduction of beta1-adrenergic receptor mRNA in heart failure

1996 • 134 citations

Effects of Carvedilol on Right Ventricular Function in Chronic Heart Failure

1998 • 69 citations

The molecular biology of heart failure

1993 • 58 citations

Effects of carvedilol on systolic and diastolic left ventricular performance in idiopathic dilated cardiomyopathy or ischemic cardiomyopathy

1996 • 57 citations

What Type of β-Blocker Should Be Used to Treat Chronic Heart Failure?

2000 • 56 citations

Long-term beta adrenoceptor-mediated alteration in contractility and expression of phospholamban and sarcoplasmic reticulum Ca(++)-ATPase in mammalian ventricle.

1998 • 36 citations

Comparative efficacy of three indexes of left ventricular performance derived from pressure-volume loops in heart failure induced by tachypacing

1994 • 35 citations

Left ventricular diastolic collapse in regional left heart cardiac tamponade

1993 • 20 citations

Blunted peripheral vasodilatory response is a hallmark of progressive deterioration in mild to moderate congestive heart failure

2001 • 13 citations