Analysis of beta-adrenergic receptor mRNA levels in human ventricular biopsy specimens by quantitative polymerase chain reactions: Progressive reduction of beta1-adrenergic receptor mRNA in heart failure

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Current protocols in molecular biology

1988 • 7,584 citations

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

1982 • 2,259 citations

Quantitation of mRNA by the polymerase chain reaction.

1989 • 1,648 citations

Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction.

1990 • 1,484 citations

High Levels of HIV-1 in Plasma During All Stages of Infection Determined By Competitive PCR

1993 • 1,263 citations

Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group.

1990 • 1,151 citations

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

1993 • 877 citations

Transcription of the dystrophin gene in human muscle and non-muscle tissues

1988 • 733 citations

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

1987 • 687 citations

Cloning of the cDNA for the human beta 1-adrenergic receptor.

1987 • 577 citations

Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response.

1986 • 564 citations

Neurohormonal interactions and adaptations in congestive heart failure.

1988 • 540 citations

Molecular mechanisms of membrane receptor desensitization

1993 • 442 citations

Use of the polymerase chain reaction in the quantitation of MDR-1 gene expression

1990 • 427 citations

Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function.

1993 • 357 citations

Increase of Gi alpha in human hearts with dilated but not ischemic cardiomyopathy.

1990 • 324 citations

Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms.

1992 • 318 citations

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.

1994 • 300 citations

Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor

1989 • 271 citations

Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels.

1988 • 268 citations

Agonist-induced Destabilization of β-Adrenergic Receptor mRNA

1989 • 267 citations

Beta-adrenoceptors in cardiac disease

1993 • 259 citations

Differences in beta-adrenergic neuroeffector mechanisms in ischemic versus idiopathic dilated cardiomyopathy.

1991 • 254 citations

Reduced beta 1 receptor messenger RNA abundance in the failing human heart.

1993 • 237 citations

Catecholamines predict outcome in traumatic brain injury

1987 • 209 citations

cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.

1989 • 200 citations

Selective gene expression in failing human heart. Quantification of steady-state levels of messenger RNA in endomyocardial biopsies using the polymerase chain reaction.

1991 • 199 citations

Quantitation of mRNA by the polymerase chain reaction

1990 • 188 citations

Stability of nuclear RNA in mammalian cells

1974 • 182 citations

The glyceraldehyde 3 phosphate dehydrogenase gene family: structure of a human cDNA and of an X chromosome linked pseudogene; amazing complexity of the gene family in mouse.

1984 • 178 citations

Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure.

1993 • 175 citations

Myocardial beta-adrenoceptor changes in heart failure: concomitant reduction in beta,- and beta2-adrenoceptor function related to the degree of heart failure in patients with mitral valve disease

1989 • 142 citations

Beta-adrenergic agonists that down-regulate receptor mRNA up-regulate a M(r) 35,000 protein(s) that selectively binds to beta-adrenergic receptor mRNAs.

1992 • 111 citations

Distinct regulation of beta 1- and beta 2-adrenergic receptors in Chinese hamster fibroblasts.

1992 • 106 citations

β-ADRENERGIC RECEPTOR REGULATION IN THE HEART IN PATHOPHYSIOLOGIC STATES: ABNORMAL ADRENERGIC RESPONSIVENESS IN CARDIAC DISEASE

1991 • 105 citations

Angiotensinogen gene expression in extrahepatic rat tissues: Application of a solution hybridization assay

1988 • 90 citations

Beta-adrenergic agonists that down-regulate receptor mRNA up-regulate a M(r) 35,000 protein(s) that selectively binds to beta-adrenergic receptor mRNAs.

1992 • 87 citations

Multi-target PCR analysis by capillary electrophoresis and laser-induced fluorescence

1994 • 85 citations

Drug- and disease-induced changes of human cardiac 1- and 2-adrenoceptors

1989 • 84 citations

Down-regulation of β-adrenergic receptor : agonist-induced reduction in mRNA levels

1988 • 82 citations

Abnormalities of peripheral sympathetic nervous system control in congestive heart failure.

1990 • 81 citations

Distinct down-regulation of cardiac ?1- and ?2-adrenoceptors in different human heart diseases

1991 • 70 citations

Myocardial beta-adrenergic receptor expression and signal transduction after chronic volume-overload hypertrophy and circulatory congestion.

1992 • 61 citations

Abnormalities in sympathoneuronal regulation are localized to failing myocardium in rabbit heart

1994 • 44 citations