Islet-activating protein inhibits leukotriene D4- and leukotriene C4- but not bradykinin- or calcium ionophore-induced prostacyclin synthesis in bovine endothelial cells.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

A Blood Vessel Model Constructed from Collagen and Cultured Vascular Cells

1986 • 1,224 citations

A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.

1980 • 841 citations

Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

1982 • 808 citations

ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.

1982 • 600 citations

Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

1984 • 498 citations

Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

1983 • 493 citations

5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

1985 • 429 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.

1983 • 406 citations

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

1984 • 389 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

Identification of the C(6)-S-conjugate of leukotriene a with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity

1980 • 267 citations

Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.

1985 • 245 citations

Bradykinin-activated transmembrane signals are coupled via No or Ni to production of inositol 1,4,5-trisphosphate, a second messenger in NG108-15 neuroblastoma-glioma hybrid cells.

1986 • 182 citations

A guanine nucleotide-dependent phosphatidylinositol 4,5-diphosphate phospholipase C in cells transformed by the v-fms and v-fes oncogenes.

1986 • 168 citations

Peptidoleukotrienes: Distinct receptors for leukotriene C4 and D4 in the Guinea-pig lung

1983 • 104 citations

Leukotriene C4 binding to rat lung membranes.

1983 • 97 citations

Leukotriene D4 treatment of bovine aortic endothelial cells and murine smooth muscle cells in culture results in an increase in phospholipase A2 activity.

1986 • 90 citations

Binding of leukotrienes C4 and D4 to membranes from guinea pig lung: Regulation by ions and gaunine nucleotides

1983 • 83 citations

Guanine nucleotide activation and inhibition of adenylate cyclase as modified by islet-activating protein, pertussis toxin, in mouse 3T3 fibroblasts

1983 • 73 citations

Molecular heterogeneity of leukotriene receptors: correlation of smooth muscle contraction and radioligand binding in guinea-pig lung.

1985 • 69 citations

Specific receptors for leukotriene C4 on a smooth muscle cell line.

1983 • 66 citations

Effect of leukotrienes, bradykinin and calcium ionophore (A 23187) on bovine endothelial cells: Release of prostacyclin

1986 • 61 citations

Identification and characterization of leukotriene D4 receptors in adult and fetal human lung

1985 • 56 citations

Regulation of ligand binding to leukotriene D4 receptors: effects of cations and guanine nucleotides

1984 • 46 citations

Identification of specific binding sites for leukotriene C4 in human fetal lung

1984 • 40 citations

The binding of leukotriene C4 and leukotriene D4 to membranes of a smooth muscles cell line (BC3H1) and evidence that leukotriene induced contraction in these cells is mediated by thromboxane, protein and RNA syntheses

1985 • 26 citations

Leukotriene C4 ([3H] - LTC4) binding to membranes isolated from a hamster smooth muscle cell line (DDTIMF2)

1984 • 22 citations

Characterization of [3H]leukotriene D4 binding sites in guinea-pig ventricular myocardium.

1985 • 20 citations

Characterization of guinea pig myocardial leukotriene C4 binding sites. Regulation by cations and sulfhydryl-directed reagents.

1985 • 19 citations

Identification of leukotriene D4 specific binding sites in the membrane preparation isolated from guinea pig lung

1984 • 19 citations

Solubilization of [3H]leukotriene D4 receptor complex from guinea pig lung membranes.

1986 • 16 citations