Expression of Calbindin-D_28kin a Pancreatic Isletβ -Cell Line Protects against Cytokine-Induced Apoptosis and Necrosis

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Caspases: Enemies Within

1998 • 6,923 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

Superoxide in Apoptosis

1998 • 773 citations

Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca²⁺ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

1995 • 616 citations

The role of interleukin-1 in the pathogenesis of IDDM

1996 • 528 citations

Cytokines and Their Roles in Pancreatic Islet β-Cell Destruction and Insulin-Dependent Diabetes Mellitus

1998 • 467 citations

Vitamin D-Dependent Calcium Binding Proteins: Chemistry, Distribution, Functional Considerations, and Molecular Biology*

1989 • 428 citations

An improved MIT assay

1993 • 382 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

1995 • 343 citations

Cytokines Induce Deoxyribonucleic Acid Strand Breaks and Apoptosis in Human Pancreatic Islet Cells*

1997 • 302 citations

Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors.

1996 • 300 citations

Prevention of diabetes in NOD mice treated with antibody to murine IFNγ

1991 • 263 citations

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

1995 • 248 citations

The reevaluation of the ferric thiocyanate assay for lipid hydroperoxides with special considerations of the mechanistic aspects of the response

1996 • 237 citations

The Role of Peroxynitrite in Nitric Oxide-Mediated Toxicity

1995 • 222 citations

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: Reduced oxidative stress and preserved mitochondrial function

1998 • 216 citations

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

2000 • 211 citations

Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.

1999 • 204 citations

Apoptosis Is the Mode of β-Cell Death Responsible for the Development of IDDM in the Nonobese Diabetic (NOD) Mouse

1997 • 203 citations

Tumor necrosis factor alpha induces apoptosis in mammary adenocarcinoma cells by an increase in intranuclear free Ca2+ concentration and DNA fragmentation.

1992 • 190 citations

Islet Cell DNA Is a Target of Inflammatory Attack by Nitric Oxide

1993 • 180 citations

IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice.

1995 • 160 citations

Development of Autoimmune Diabetes in NOD Mice Is Associated With the Formation of Peroxynitrite in Pancreatic Islet β-Cells

1997 • 149 citations

Calbindin-D28k Is Expressed in Osteoblastic Cells and Suppresses Their Apoptosis by Inhibiting Caspase-3 Activity

2000 • 140 citations

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

1993 • 133 citations

Calbindin-D28k Controls [Ca2+] and Insulin Release

1999 • 128 citations

Stable expression of the calbindin-D28K complementary DNA interferes with the apoptotic pathway in lymphocytes.

1992 • 125 citations

Cytokine-induced apoptotic cell death in a mouse pancreatic beta-cell line: inhibition by Bcl-2

1996 • 122 citations

Tumor Necrosis Factor-α and Interferon-γ Inhibit Insulin Secretion and Cause DNA Damage in Unweaned-Rat Islets: Extent of Nitric Oxide Involvement

1996 • 115 citations

Analysis of TNF alpha-induced DNA strand breaks at the single cell level.

1991 • 111 citations

Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death

1996 • 106 citations

Tumor Necrosis Factor-α-Activated Cell Death Pathways in NIT-1 Insulinoma Cells and Primary Pancreatic β Cells*

1999 • 104 citations

Pancreatic beta cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: a potentially general technique for isolating physiologically representative cell lines.

1993 • 102 citations

Regulation of Insulin Secretion from β-Cell Lines Derived from Transgenic Mice Insulinomas Resembles that of Normal β-Cells*

1990 • 99 citations

Calcium: The Molecular Basis of Calcium Action in Biology and Medicine

2000 • 93 citations

Insulin-dependent diabetes mellitus as a β-cell targeted disease of immunoregulation

1995 • 91 citations

Expression of calbindin-D28K in motoneuron hybrid cells after retroviral infection with calbindin-D28K cDNA prevents amyotrophic lateral sclerosis IgG-mediated cytotoxicity.

1996 • 91 citations

Sensitive determination of nitrotyrosine in human plasma by isocratic high-performance liquid chromatography

1996 • 91 citations

Quantitation of Protein-Bound 3-Nitrotyrosine and 3,4-Dihydroxyphenylalanine by High-Performance Liquid Chromatography with Electrochemical Array Detection

1997 • 88 citations

Calbindin D_28K Gene Transfer via Herpes Simplex Virus Amplicon Vector Decreases Hippocampal Damage In Vivo Following Neurotoxic Insults

1999 • 88 citations

Vitamin D-Dependent Rat Renal Calcium-Binding Protein: Development of a Radioimmu no assay, Tissue Distribution, and Immunologic Identification*

1984 • 84 citations

Expression of calbindin-D28k in C6 glial cells stabilizes intracellular calcium levels and protects against apoptosis induced by calcium ionophore and amyloid β-peptide

1999 • 75 citations

A Low Voltage-Activated Ca2+ Current Mediates Cytokine-Induced Pancreatic β-Cell Death*

1999 • 73 citations

Destruction of rat pancreatic islet beta-cells by cytokines involves the production of cytotoxic aldehydes.

1996 • 59 citations

Altered bcl-2 and bax Expression and Intracellular Ca2+ Signaling in Apoptosis of Pancreatic Cells and the Impairment of Glucose-Induced Insulin Secretion*

1998 • 55 citations

Essential role of caspase-3 in apoptosis of mouse beta-cells transfected with human Fas.

1999 • 52 citations

Prevention of Spontaneous Autoimmune Diabetes in Diabetes-Prone BB Rats by Prophylactic Treatment with Antirat Interferon-γ Antibody

1997 • 52 citations

Calbindin Expression in Renal Tubular Epithelial Cells. ALTERED SODIUM PHOSPHATE CO-TRANSPORT IN ASSOCIATION WITH CYTOSKELETAL REARRANGEMENT

1995 • 16 citations

Activation of Programmed Cell Death by Calcium: Protection against Cell Death by the Calcium Binding Protein, Calbindin-D28k

2000 • 7 citations