Nkx2-5 Pathways and Congenital Heart Disease

Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy

2001 • 1,490 citations

Congenital Heart Disease Caused by Mutations in the Transcription Factor NKX2-5

1998 • 1,284 citations

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1995 • 1,272 citations

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

2003 • 1,187 citations

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.

1995 • 1,130 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease

2001 • 1,022 citations

Embryonic stem cells alone are able to support fetal development in the mouse

1990 • 789 citations

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

1999 • 667 citations

Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

1999 • 666 citations

Chapter 13 Fluorescence Microscopy in Three Dimensions

1989 • 662 citations

The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development

1999 • 552 citations

BMP10 is essential for maintaining cardiac growth during murine cardiogenesis

2004 • 473 citations

HISTOCHEMICAL METHODS FOR SEPARATE, CONSECUTIVE AND SIMULTANEOUS DEMONSTRATION OF ACETYLCHOLINESTERASE AND NOREPINEPHRINE IN CRYOSTAT SECTIONS

1967 • 400 citations

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.

2000 • 335 citations

NKX2.5 Mutations in Patients With Tetralogy of Fallot

2001 • 333 citations

Ventricular muscle-restricted targeting of the RXRα gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis

1998 • 285 citations

Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development

2002 • 281 citations

Transcriptional Regulation of Vertebrate Cardiac Morphogenesis

2002 • 266 citations

Cardiac HCN Channels Structure, Function, and Modulation

2002 • 256 citations

Cardiac homeobox gene NKX2-5mutations and congenital heart disease

2003 • 244 citations

Neuregulin-1 promotes formation of the murine cardiac conduction system

2002 • 244 citations

The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system

1993 • 236 citations

Modulation of Cardiac Growth and Development by HOP, an Unusual Homeodomain Protein

2002 • 231 citations

Antagonistic Signals between BMP4 and FGF8 Define the Expression of Pitx1 and Pitx2 in Mouse Tooth-Forming Anlage

2000 • 200 citations

Replacement by Homologous Recombination of the minK Gene With lacZ Reveals Restriction of minK Expression to the Mouse Cardiac Conduction System

1999 • 188 citations

A Combined Morphological and Electrophysiological Study of the Atrioventricular Node of the Rabbit Heart

1974 • 163 citations

Heart specific expression of mouse BMP-10 a novel member of the TGF-β superfamily

1999 • 147 citations

A Novel Genetic Pathway for Sudden Cardiac Death via Defects in the Transition between Ventricular and Conduction System Cell Lineages

2000 • 133 citations

Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system

2003 • 122 citations

Atrial Chamber-specific Expression of Sarcolipin Is Regulated during Development and Hypertrophic Remodeling

2003 • 119 citations

Comparison of Ion-Channel Subunit Expression in Canine Cardiac Purkinje Fibers and Ventricular Muscle

2002 • 119 citations

Ventricular noncompaction and distal chromosome 5q deletion

1999 • 99 citations

Localisation and quantitation of autonomic innervation in the porcine heart I: conduction system

1999 • 95 citations

Localisation and quantitation of autonomic innervation in the porcine heart II: endocardium, myocardium and epicardium

1999 • 84 citations

Elevated expression of Nkx-2.5 in developing myocardial conduction cells

2001 • 79 citations

Homeodomain Factor Nkx2-5 in Heart Development and Disease

2002 • 77 citations

Progressive AV-block and anomalous venous return among cardiac anomalies associated with two novel missense mutations in theCSX/NKX2-5 Gene

2002 • 74 citations

Developing models of DiGeorge syndrome

2001 • 70 citations

Development of the Cardiac Conduction System as Delineated by minK‐lacZ

2003 • 65 citations

Molecular characterization of the ventricular conduction system in the developing mouse heart: topographical correlation in normal and congenitally malformed hearts

2001 • 60 citations

How Constant Anatomically is the Tendon of Todaro as a Marker for the Triangle of Koch?

2000 • 48 citations

Molecular Basis of the Effect of Potassium on Heterologously Expressed Pacemaker (HCN) Channels

2003 • 46 citations

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