Drug glucuronidation in humans

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

The Metabolic Basis of Inherited Disease

1979 • 2,083 citations

Glucuronidation of Drugs and Other Compounds

2019 • 807 citations

The Metabolic Basis of Inherited Disease

1983 • 757 citations

Termination of Pregnancy on Psychiatric Grounds

1964 • 683 citations

Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide

1990 • 446 citations

Reversibility by dipyridamole of thallium-201 myocardial scan defects in patients with sarcoidosis

1988 • 366 citations

Chloramphenicol in the Newborn Infant

1960 • 352 citations

Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency

1969 • 332 citations

UDP-glucuronosyltransferases

1989 • 327 citations

Acetaminophen elimination kinetics in neonates, children, and adults

1976 • 301 citations

Lamotrigine, a new anticonvulsant: Pharmacokinetics in normal humans

1987 • 273 citations

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells.

1991 • 261 citations

Effects of aging and liver disease on disposition of lorazepam

1978 • 253 citations

Stereoselective disposition of ibuprofen enantiomers in man.

1985 • 253 citations

Conjugation Reactions in Drug Metabolism

1991 • 253 citations

Morphine Pharmacokinetics in Early Infancy

1987 • 242 citations

UDP-glucur-onosyltransferases

1989 • 240 citations

Normal Disposition of Oxazepam in Acute Viral Hepatitis and Cirrhosis

1976 • 238 citations

The Relationship of Pharmacokinetics to Pharmacological Activity

1976 • 231 citations

The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes.

1988 • 229 citations

Stereoselective disposition of ibuprofen enantiomers in infants.

1994 • 217 citations

Oxazepam kinetics: effects of age and sex.

1980 • 203 citations

Limited capacity for salicyl phenolic glucuronide formation and its effect on the kinetics of salicylate elimination in man

1972 • 202 citations

The metabolism and bioavailability of morphine in patients with severe liver cirrhosis.

1990 • 198 citations

Drug Disposition in Obese Humans

1986 • 193 citations

Pharmacokinetics and metabolism of epidoxorubicin and doxorubicin in humans.

1988 • 192 citations

Disposition in male volunteers of a subanaesthetic intravenous dose of an oil in water emulsion of¹⁴C-propofol

1988 • 188 citations

Pharmacokinetics of Acetaminophen in the Human Neonate: Formation of Acetaminophen Glucuronide and Sulfate in Relation to Plasma Bilirubin Concentration and D-Glucaric Acid Excretion

1975 • 185 citations

Postoperative morphine infusion in newborn infants: Assessment of disposition characteristics and safety

1985 • 184 citations

Influence of sex and oral contraceptive steroids on paracetamol metabolism.

1983 • 180 citations

Age-related morphine kinetics

1983 • 172 citations

Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells.

1988 • 169 citations

Effect of age and gender on disposition of temazepam

1981 • 164 citations

Lorazepam kinetics in the elderly

1979 • 152 citations

Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates.

1990 • 151 citations

Morphine metabolism in children.

1989 • 147 citations

Stereoselective delivery and actions of beta receptor antagonists

1988 • 145 citations

A KINETIC STUDY OF DRUG ELIMINATION: THE EXCRETION OF PARACETAMOL AND ITS METABOLITES IN MANMETABOLITES IN MAN

1967 • 143 citations

Enhanced phenacetin metabolism in human subjects fed charcoal‐broiled beef

1976 • 141 citations

Morphine glucuronidation in human fetal and adult liver

1982 • 140 citations

Drug Biotransformation Interactions in Man VI: Acetaminophen and Ascorbic Acid

1976 • 138 citations

Inter‐subject and ethnic differences in paracetamol metabolism.

1986 • 137 citations

Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one

1990 • 135 citations

Ketorolac tromethamine absorption, distribution, metabolism, excretion, and pharmacokinetics in animals and humans.

1987 • 134 citations

Enhanced Bioavailability and Decreased Clearance of Analgesics in Patients with Cirrhosis

1979 • 133 citations

Drug Biotransformation Interactions in Man I

1968 • 131 citations

Pharmacokinetics of salicylamide elimination in man.

1967 • 130 citations

Developmental pharmacology

1964 • 126 citations

Cimetidine spares the glucuronidation of lorazepam and oxazepam

1980 • 125 citations

Regulation of sexual differentiation in drug and steroid metabolism

1989 • 124 citations

Obesity, sex, and acetaminophen disposition

1982 • 123 citations

CLOFIBRATE-INDUCED MUSCLE DAMAGE IN PATIENTS WITH CHRONIC RENAL FAILURE

1975 • 122 citations

Effect of brussels sprouts and cabbage on drug conjugation

1984 • 121 citations

The metabolic fate of codeine in man.

1955 • 119 citations

Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex

1989 • 118 citations

Pathway-selective sex differences in the metabolic clearance of propranolol in human subjects

1989 • 118 citations

Negligible excretion of unchanged ketoprofen, naproxen, and probenecid in urine

1980 • 116 citations

Interindividual and interethnic differences in the demethylation and glucuronidation of codeine.

1989 • 115 citations

Metabolism of labetalol by animals and man.

1976 • 114 citations

Enhanced glucuronide conjugation of drugs in obesity: studies of lorazepam, oxazepam, and acetaminophen.

1983 • 112 citations

Drug Biotransformation Interactions in Man III: Acetaminophen and Salicylamide

1971 • 111 citations

The metabolism of aspirin in man: a population study

1986 • 110 citations

Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA

1987 • 110 citations

The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a −1 frameshift mutation

1989 • 108 citations

A Biochemical Lesion in Congenital, Non-obstructive, Non-hæmolytic Jaundice

1957 • 104 citations

Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics

1984 • 104 citations

GLUCURONIC ACID CONJUGATION BY PATIENTS WITH FAMILIAL NONHEMOLYTIC JAUNDICE AND THEIR RELATIVES

1959 • 101 citations

Drug metabolism in liver disease

1989 • 100 citations

Development of multiple activities of UDP-glucuronyltransferase in human liver

1987 • 98 citations

Pharmacokinetics of valproic acid in the elderly.

1984 • 95 citations

Paracetamol as a test drug to determine glucuronide formation in man. Effects of inducers and of smoking

1987 • 95 citations

Acetaminophen kinetics in the elderly

1982 • 95 citations

Influences of Diet and Nutrition on Clinical Pharmacokinetics

1988 • 95 citations

Clinical Pharmacokinetics of Chloramphenicol and Chloramphenicol Succinate

1984 • 93 citations

The enantioselective glucuronidation of morphine in rats and humans

1989 • 93 citations

Determinants of acetaminophen metabolism: Effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways

1984 • 91 citations

Pharmacokinetics of ketoprofen in the elderly.

1983 • 90 citations

Hepatic extraction of morphine is impaired in cirrhosis

1989 • 90 citations

Age-related differences in salicylamide and acetaminophen conjugation in man

1977 • 88 citations

Glucuronide Formation in Patients with Constitutional Hepatic Dysfunction (Gilbert's Disease)

1959 • 88 citations

Effects of microsomal enzyme induction on paracetamol metabolism in man.

1981 • 87 citations

Paracetamol metabolism in chronic liver disease

1979 • 85 citations

Kinetics of Salicylate Elimination by Newborn Infants of Mothers Who Ingested Aspirin Before Delivery

1974 • 84 citations

Influence of gender and oral contraceptive steroids on the metabolism of salicylic acid and acetylsalicylic acid.

1986 • 84 citations

Paracetamol disposition in normal subjects and in patients treated with antiepileptic drugs.

1979 • 81 citations

Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation.

1985 • 81 citations

Expression of a human liver cDNA encoding a UDP‐glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture

1989 • 80 citations

Paracetamol metabolism in pregnancy.

1986 • 80 citations

Species differences in metabolism of ketotifen in rat, rabbit and man: Demonstration of similar pathways and in cultured hepatocytes

1987 • 79 citations

Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: Possible alternate splicing of a common primary transcript

1990 • 79 citations

PHARMACOKINETICS AND METABOLISM OF TEMAZEPAM IN MAN AND SEVERAL ANIMAL SPECIES

1979 • 79 citations

The role of conjugation reactions in detoxication

1987 • 78 citations

Decreased first-pass metabolism of labetalol in chronic liver disease.

1978 • 77 citations

Pharmacokinetic and pharmacodynamic consequences of stereoselective drug metabolism in man

1988 • 74 citations

Differential effect of cimetidine on drug oxidation (antipyrine and diazepam) vs. conjugation (acetaminophen and lorazepam): prevention of acetaminophen toxicity by cimetidine.

1983 • 74 citations

Species-dependent enantioselective glucuronidation of three 2-arylpropionic acids. Naproxen, ibuprofen, and benoxaprofen.

1987 • 74 citations

Stereoselective disposition of mexiletine in man.

1986 • 74 citations

Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle.

1983 • 74 citations

Pharmacokinetics of zidovudine in patients with liver cirrhosis

1990 • 73 citations

Acetaminophen pharmacokinetics: Comparison between pregnant and nonpregnant women

1986 • 73 citations

Pharmacokinetics of Ketoprofen Enantiomers in Young and Elderly Arthritic Patients following Single and Multiple Doses

1988 • 73 citations

Comparison of paracetamol metabolism in young adult and elderly males

1988 • 72 citations

Naproxen‐probenecid interaction

1978 • 71 citations

Effect of probenecid on the formation and elimination of acyl glucuronides: Studies with zomepirac

1985 • 71 citations

The Metabolism of Labetalol in Animals and Man

1976 • 70 citations

Urinary Excretion of Valproate and Some Metabolites in Chronically Treated Patients

1989 • 69 citations

The pharmacokinetics of lamotrigine (BW430C) in healthy subjects with unconjugated hyperbilirubinaemia (Gilbert's syndrome).

1989 • 68 citations

Isolation and purification of two human liver UDP-glucuronosyltransferases.

1987 • 68 citations

Biotransformation and pharmacokinetics of sulfinpyrazone (Anturan�) in man

1975 • 67 citations

Effects of probenecid on ketoprofen kinetics

1982 • 67 citations

IS THERE A PLACE FOR CIMETIDINE OR ETHANOL IN THE TREATMENT OF PARACETAMOL POISONING?

1983 • 67 citations

Paracetamol metabolites in the neonate following maternal overdose.

1984 • 65 citations

The pharmacokinetics of benoxaprofen in elderly subjects.

1982 • 65 citations

Environmental factors affecting paracetamol metabolism in London factory and office workers.

1980 • 65 citations

Effects of oral contraceptive steroids on acetaminophen metabolism and elimination

1983 • 63 citations

The Liver in Pregnancy

1975 • 62 citations

Selective induction of propranolol metabolism by smoking: additional effects on renal clearance of metabolites.

1987 • 62 citations

Chloramphenicol metabolism in children with protein-calorie malnutrition

1975 • 62 citations

Determination of microsomal UDP-glucuronyltransferase in needle-biopsy specimens of human liver

1978 • 62 citations

The Metabolism of Terbutaline in Man

1972 • 61 citations

Effect of cigarette smoking on mexiletine kinetics

1985 • 59 citations

Glucuronidation of Codeine and Morphine in Human Liver and Kidney Microsomes: Effect of Inhibitors

1990 • 58 citations

Kinetic and inhibitor studies of 4-methylumbelliferone and 1-naphthol glucuronidation in human liver microsomes

1988 • 57 citations

The effects of age and chronic liver disease on the elimination of temazepam

1986 • 57 citations

Gender and oral contraceptive steroids as determinants of drug glucuronidation: effects on clofibric acid elimination.

1984 • 56 citations

Codeine disposition in smokers and nonsmokers

1982 • 56 citations

In vitro evidence for the involvement of at least two forms of human liver UDP-glucuronosyltransferase in morphine 3-glucuronidation

1988 • 56 citations

Drug metabolism in the elderly

1988 • 56 citations

Normal pathways for glucuronidation, sulphation and oxidation of paracetamol in Gilbert's syndrome

1987 • 55 citations

Placental passage of oxazepam and its metabolism in mother and newborn

1979 • 55 citations

Fetal acquisition and neonatal elimination of a large amount of salicylate

1975 • 55 citations

Human metabolism of cyproheptadine.

1975 • 55 citations

Studies of UDP-glucuronyltransferase activities in human liver microsomes.

1984 • 54 citations

Differential Effects of Oral Contraceptive Steroids on the Metabolism of Benzodiazepines

1983 • 54 citations

Clofibrate disposition in renal failure and acute and chronic liver disease

1979 • 53 citations

Immunochemical analysis of uridine diphosphate-glucuronosyltransferase in four patients with the Crigler-Najjar syndrome type I.

1990 • 52 citations

Metabolic Fate of Phenprocoumon in Humans

1985 • 52 citations

Neonatal paracetamol poisoning: treatment by exchange transfusion.

1983 • 52 citations

Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase

1990 • 50 citations

Oxaprozin pharmacokinetics in the elderly.

1985 • 49 citations

Paracetamol (Acetaminophen) Clearance in Patients with Cirrhosis of the Liver

1979 • 49 citations

Physiological disposition and metabolism of cyclobenzaprine in the rat, dog, rhesus monkey, and man.

1978 • 49 citations

Naloxone pharmacokinetics in the newborn.

1980 • 49 citations

Metabolism of tripelennamine in man.

1976 • 48 citations

Control of clofibrate toxicity in uremic hypertriglyceridemia

1977 • 47 citations

Problems in Therapeutic Drug Monitoring

1988 • 47 citations

The fate of sulphadimethoxine in primates compared with other species

1970 • 47 citations

Acetaminophen metabolism in subjects fed charcoal-broiled beef

1983 • 46 citations

The metabolism and disposition of 14C-fenofibrate in human volunteers.

1990 • 45 citations

PH dependent formation of β-glucuronidase resistant conjugates from the biosynthetic ester glucuronide of isoxepac

1981 • 45 citations

DIfferential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers

1987 • 45 citations

Benoxaprofen kinetics in renal impairment

1982 • 44 citations

The pharmacological and toxicological significance of the stereochemistry of drug disposition.

1988 • 44 citations

Pharmacokinetic Model for Nalidixic Acid in Man II

1966 • 43 citations

Phenacetin metabolism: Effect of hydrocarbons and cigarette smoking

1977 • 43 citations

The effect of sulphinpyrazone on oxidative drug metabolism in man: Inhibition of tolbutamide elimination

1982 • 43 citations

Comparative pharmacokinetics of zidovudine (AZT) and its metabolite (G.AZT) in healthy subjects and HIV seropositive patients

1989 • 42 citations

Problems in Therapeutic Drug Monitoring

1988 • 42 citations

Gilbert??s Syndrome and Drug Metabolism

1979 • 41 citations

Metabolism and kinetics of oxaprozin in normal subjects

1980 • 41 citations

Isolation and identification of the major metabolite of albuterol in human urine.

1977 • 40 citations

Increased metabolic clearance of acetaminophen with oral contraceptive use.

1982 • 40 citations

Probenecid-induced changes in the clearance of carprofen enantiomers: A preliminary study

1989 • 40 citations

Chloramphenicol Pharmacokinetics in Hospitalized Patients

1979 • 40 citations

Reduced elimination of ketoprofen in the elderly is not necessarily due to impaired glucuronidation.

1984 • 39 citations

Characterization of paracetamol UDP-glucuronosyltransferase activity in human liver microsomes

1990 • 39 citations

Induction of cytochrome P-448 iso-enzymes and related glucuronyltransferases in the human liver by cigarette smoking

1986 • 39 citations

Plasma half‐life of phenylbutazone in patients with impaired liver function

1974 • 38 citations

Paracetamol (acetaminophen) kinetics in patients with Gilbert's syndrome

1978 • 38 citations

Biotransformation of amitriptyline in depressive patients: Urinary excretion of seven metabolites

1982 • 38 citations

Sex-difference and the effects of smoking and oral contraceptive steroids on the kinetics of diflunisal

1990 • 37 citations

Acetaminophen absorption and metabolism in celiac disease and Crohn's disease

1981 • 37 citations

Interactions among chloramphenicol, phenytoin, and phenobarbital in a pediatric patient

1981 • 36 citations

Pharmacokinetics of oxazepam in healthy volunteers.

1977 • 36 citations

The Metabolites of Oxprenolol (Trasicor®) in man

1974 • 36 citations

Mexiletine kinetics in healthy subjects taking cimetidine

1985 • 35 citations

Urinary Glucuronic Acid Excretion in Liver Disease and the Effect of a Salicylamide Load

1959 • 34 citations

Maternal and neonatal urinary excretion of sulfate and glucuronide ritodrine conjugates

1988 • 34 citations

Stereoselective disposition of racemic E-10-hydroxynortriptyline in human beings

1989 • 34 citations

Comparative pharmacokinetics of paracetamol in men and women considering follicular and luteal phases.

1979 • 33 citations

Chloramphenicol and phenobarbitone--a drug interaction.

1979 • 33 citations

Abnormal Glucuronidation of Zomepirac in Patients with Cirrhosis of the Liver

1983 • 33 citations

Effect of dose on the glucuronidation and sulphation kinetics of diflunisal in man: single dose studies.

1988 • 33 citations

Pharmacokinetics of the Anti-Inflammatory Tiaprofenic Acid in Humans, Mice, Rats, Rabbits, and Dogs

1977 • 32 citations

A GLC method for estimation of chlorophenoxyisobutyric acid in plasma. Pharmacokinetics of a single oral dose of clofibrate in man

1975 • 32 citations

Lack of effect of cimetidine on acetaminophen disposition in humans

1989 • 31 citations

Ranitidine does not impair oxidative or conjugative metabolism: Noninteraction with antipyrine, diazepam, and lorazepam

1984 • 31 citations

Drug Biotransformation Interactions in Man V: Acetaminophen and Salicylic Acid

1971 • 31 citations

Glucuronidation of Morphine in Human Liver and Interaction with Oxazepam

1982 • 31 citations

Probenecid-clofibrate interaction

1981 • 30 citations

Tocainide kinetics and metabolism: Effects of phenobarbital and substrates for glucuronyl transferase

1980 • 30 citations

Interaction between chloramphenicol and paracetamol.

1979 • 30 citations

The effect of carbamazepine on valproic acid disposition in adult volunteers.

1989 • 29 citations

Evidence for a dual action of sulphinpyrazone on drug metabolism in man: theophylline‐sulphinpyrazone interaction.

1983 • 29 citations

Preliminary studies of absorption and excretion of benoxaprofen in man.

1977 • 29 citations

Chloramphenicol pharmacokinetics in Ethiopian children of differing nutritional status

1983 • 29 citations

Metabolism of phenylbutazone in man.

1976 • 28 citations

Lorazepam conjugation is unimpaired in burn trauma

1988 • 28 citations

Oxazepam pharmacokinetics in patients with epilepsy treated long‐term with phenytoin alone or in combination with phenobarbitone.

1983 • 27 citations

Bromperidol

1988 • 26 citations

Comparative study of clofibric acid and bilirubin glucuronidation in human liver microsomes

1987 • 26 citations

Routes of conjugation in normal and cancerous tissue from human lung

1981 • 26 citations

Identification of the major urinary metabolite of alprenolol in man, dog and rat

1974 • 25 citations

Persistently increased expression of a 3-methylcholanthrene-inducible phenol uridine diphosphate-glucuronosyltransferase in rat hepatocyte nodules and hepatocellular carcinomas.

1990 • 25 citations

Metabolism of pirprofen in man, monkey, rat, and mouse.

1982 • 25 citations

Drug metabolism in white vegetarians.

1980 • 25 citations

Single- and multiple-dose pharmacokinetics of R-(?)- and S-(+)-prenylamine in man

1990 • 24 citations

The Metabolism of Terbutaline in Dog and Rat

1973 • 24 citations

Alclofenac

1977 • 23 citations

The metabolism of ICI 118,587, a partial agonist of beta 1-adrenoceptors, in mice, rats, rabbits, dogs, and humans.

1984 • 23 citations

Sources of interindividual variations in acetaminophen and antipyrine metabolism

1984 • 23 citations

Reduction of Paracetamol and Aspirin Metabolism During Viral Hepatitis

1986 • 22 citations

Pharmacokinetics of naproxen in elderly patients

1986 • 22 citations

Effect of Pentobarbital on the Formation of Diastereomeric Oxazepam Glucuronides in Man: Analysis by High Performance Liquid Chromatography

1981 • 21 citations

Stereoselective disposition of RS-tocainide in man

1984 • 21 citations

Interaction of Cimetidine with Oxazepam, Lorazepam, and Flurazepam

1984 • 21 citations

Interaction of oxaprozin with acetaminophen, cimetidine, and ranitidine

1986 • 21 citations

Species differences in the metabolism of suprofen in laboratory animals and man.

1985 • 21 citations

Pharmacokinetics of ketoprofen enantiomers in cholecystectomy patients: influence of probenecid

1989 • 20 citations

Metabolic interaction between morphine and naloxone in human liver. A common pathway of glucuronidation?

1989 • 20 citations

Isolation and characterization of an unusual glucuronide conjugate of rimantadine.

1990 • 20 citations

Disposition of Zomepirac Sodium in Man

1982 • 20 citations

Interaction of sulphinpyrazone with warfarin

1982 • 20 citations

Identification of major metabolites of the catechol-O-methyltransferase-inhibitor nitecapone in human urine.

1991 • 19 citations

Effect of oral contraceptive steroids on the pharmacokinetics of phenprocoumon.

1990 • 19 citations

Interethnic differences in drug glucuronidation: a comparison of paracetamol metabolism in Caucasians and Chinese.

1991 • 19 citations

A PHARMACOKINETIC INTERACTION IN MAN BETWEEN PHENOBARBITONE AND FENOPROFEN, A NEW ANTI‐INFLAMMATORY AGENT

1974 • 18 citations

The metabolic disposition of the selective beta 1-adrenoceptor agonist prenalterol in mice, rats, dogs, and humans.

1982 • 18 citations

The Influence of Liver Dysfunction on the Pharmacokinetics of Carprofen

1985 • 18 citations

Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism

1988 • 18 citations

Pharmacokinetics of tocainide in patients with combined hepatic and renal dysfunction

1983 • 17 citations

Etodolac kinetics in the elderly

1986 • 17 citations

Pharmacokinetic interaction between indomethacin and diflunisal

1989 • 17 citations

Zur Frage der Glucuronbildung bei der funktionellen Hyperbilirubinämie unter Berücksichtigung der renalen Glucuronid-Clearance

1960 • 17 citations

Expression of specific UDP-glucuronosyltransferase isoforms in carcinogen-induced preneoplastic rat liver nodules

1991 • 14 citations

Lack of effect of paracetamol on the pharmacokinetics of chloramphenicol.

1989 • 14 citations

Lack of effect of paracetamol on the pharmacokinetics and metabolism of codeine in man

1991 • 14 citations

UDP-glucuronyltransferase activity toward harmol in human liver and human fetal liver cells in culture

1990 • 13 citations

Kinetics of oral and intravenous mexiletine: lack of effect of cimetidine and ranitidine

1989 • 13 citations

Reduced Distribution and Clearance of Acetaminophen in Patients with Congestive Heart Failure

1983 • 13 citations

Close correlation of acetaminophen clearance with that of conjugated benzodiazepines but not oxidized benzodiazepines

1983 • 13 citations

Cimetidine—Acetaminophen Interaction in Humans

1985 • 12 citations

Metabolites of feprazone in man.

1979 • 12 citations

Sex differences in salicylic acid metabolism in Nigerian subjects

1986 • 12 citations

Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism.

1990 • 12 citations

Pharmacokinetics of oxaprozin in women receiving conjugated estrogen

1988 • 11 citations

Expression of specific UDP-glucuronosyltransferase isoforms in carcinogen-induced preneoplastic rat liver nodules

1991 • 11 citations

Single and multiple dose pharmacokinetics of enteric coated ketoprofen: Effect of cimetidine

1988 • 10 citations

Conjugation of 1-naphthol by human colon and tumour tissue using different experimental systems

1984 • 9 citations

Effects of Liver Disease on the Disposition of Ciramadol in Humans

1989 • 9 citations

Acetaminophen pharmacokinetics in women receiving conjugated estrogen

1990 • 8 citations

Conjugation pathways in human bronchial carcinoma cell lines

1981 • 8 citations

Single dose oxazepam has no effect on acetaminophen clearance or metabolism

1986 • 8 citations

Assessment of the drug inhibitor specificity of the human liver 4-methylumbelliferone UDP-glucuronosyltransferase activity

1991 • 8 citations

Zomepirac‐Aspirin Interactions in Man

1984 • 7 citations

Disposition in humans of racemic picenadol, an opioid analgesic.

1990 • 5 citations

The metabolic disposition of¹⁴C-ciramadol in humans

1986 • 5 citations

Identification of DP-1904 and its ester glucuronide in human urine and determination of their enantiomeric compositions by high-performance liquid chromatography with optical activity and ultraviolet detection.

1990 • 5 citations

Disposition of bemitradine, a Renal Vasodilator and Diuretic, in Man

1988 • 5 citations

Enhanced oral bioavailability of meptazinol in cirrhosis.

1987 • 5 citations

The effects of frusemide and probenecid on the pharmacokinetics of phenprocoumon

1990 • 5 citations

Lack of effect of valproate on paracetamol (acetaminophen) disposition in epileptic patients.

1981 • 4 citations

Codeine disposition and metabolisin: comparison in young and elderly subjects

1990 • 4 citations

Salivary paracetamol elimination kinetics during the menstrual cycle.

1987 • 4 citations

Quantitative Aspects of the Urinary Excretion of Meptazinol and Its Metabolites in Human Volunteers

1989 • 4 citations

The disposition of meptazinol after single and multiple intravenous administration to pregnant and non-pregnant women

1989 • 4 citations

Pharmacokinetic characteristics of bornaprolol in healthy volunteers

1990 • 2 citations