Stereoselective disposition of ibuprofen enantiomers in man.

The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequences

1983 • 395 citations

Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (—)-isomer

1976 • 378 citations

Noncompartmental Determination of the Steady-State Volume of Distribution for Any Mode of Administration

1982 • 288 citations

Advances in Drug Research

1965 • 233 citations

Isomeric inversion of ibuprofen (r)‐enantiomer in humans

1976 • 189 citations

Enzymatic inversion at saturated carbon: Nature and mechanism of the inversion of R(−) p-iso-butyl hydratropic acid

1974 • 133 citations

Pharmacokinetics of ibuprofen in man. I. Free and total area/dose relationships

1983 • 114 citations

Stereoisomeric relationships among anti-inflammatory activity, inhibition of platelet aggregation, and inhibition of prostaglandin synthetase

1975 • 100 citations

Separation and determination of naproxen enantiomers in serum by high-performance liquid chromatography

1982 • 93 citations

Stereospecific inversion of (R)-(−)-benoxaprofen in rat and man

1980 • 78 citations

Liquid Chromatographic Determination and Plasma Concentration Profile of Optical Isomers of Ibuprofen in Humans

1984 • 77 citations

Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle.

1983 • 74 citations

Dose‐response study with ibuprofen in rheumatoid arthritis: clinical and pharmacokinetic findings.

1983 • 71 citations

High-performance liquid chromatographic determination of ibuprofen and its major metabolites in biological fluids

1982 • 69 citations

Stereoselective inversion of (R)-(-)-benoxaprofen to the (S)-(+)-enantiomer in humans.

1979 • 64 citations

A commentary: methods and assumptions in the kinetic estimation of metabolite formation.

1983 • 64 citations

Ibuprofen and sulindac kinetics in alcoholic liver disease

1983 • 59 citations

Stereoisomeric relationships among anti-inflammatory activity, inhibition of platelet aggregation, and inhibition of prostaglandin synthetase

1975 • 47 citations

Relative Bioavailability of Commercially Available Ibuprofen Oral Dosage Forms in Humans

1982 • 35 citations

Inversion of optical configuration of alpha-methylfluorene-2-acetic acid (cicloprofen) in rats and monkeys.

1976 • 34 citations

Optical isomerization of R(−)-clidanac to the biologically active S(+)-isomer in guinea-pigs

1981 • 21 citations

Structure Activity Relationship Among 6-Substituted-2-Naphthylacetic Acids: A New Series of Nonsteroidal Anti-inflammatory Agents

1973 • 13 citations

Biological Activities of Optical Isomers of 6-Chloro-5-Cyclohexylindan-1-Carboxylic Acid (Tai-284: Anti-Inflammatory Agent)

1974 • 10 citations