Stereoselective delivery and actions of beta receptor antagonists

A physiological approach to hepatic drug clearance

1975 • 1,855 citations

PC12 Pheochromocytoma Cultures in Neurobiological Research

1982 • 728 citations

Plasma Propranolol Levels in the Quantitative Assessment of -adrenergic Blockade in Man

1970 • 296 citations

Increased Plasma Protein Binding of Propranolol and Chlorpromazine Mediated by Disease-Induced Elevations of Plasma α₁Acid Glycoprotein

1978 • 293 citations

Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers

1983 • 215 citations

Metabolism of metoprolol‐(³H) in man, the dog and the rat

1975 • 162 citations

The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation

1986 • 130 citations

Stereoselective Disposition and Glucuronidation of Propranolol in Humans

1982 • 124 citations

Quantitative account of propranolol metabolism in urine of normal man.

1985 • 117 citations

Stereoselective binding of propranolol to human plasma, α1-acid glycoprotein, and albumin

1983 • 113 citations

Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers

1986 • 113 citations

Stereoselective renal clearance of pindolol in humans.

1985 • 86 citations

Polymorphic ability to metabolize propranolol alters 4-hydroxypropranolol levels but not beta blockade

1984 • 81 citations

Steady-state kinetics of catecholamine transport by chromaffin-granule ‘ghosts’

1974 • 79 citations

Plasma levels of (+) and (−)−propranolol and 4‐hydroxypropranolol after administration of racemic (+/‐)‐propranolol in man.

1982 • 77 citations

4-Hydroxypropranolol and its glucuronide after single and long-term doses of propranolol

1980 • 70 citations

Food effects on propranolol systemic and oral clearance: Support for a blood flow hypothesis

1986 • 69 citations

Stereoselective ring oxidation of propranolol in man.

1984 • 67 citations

The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol.

1984 • 66 citations

Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism) — Increased michaelis constant (km) and loss of stereoselectivity of bufuralol 1′-hydroxylation in poor metabolizers

1984 • 66 citations

Genetic polymorphism in drug oxidation: In vitro studies of human debrisoquine 4-hydroxylase and bufuralol 1′-hydroxylase activities

1985 • 65 citations

Studies on the antihypertensive action of the optical isomers of propranolol in man

1974 • 63 citations

Selective induction of propranolol metabolism by smoking: additional effects on renal clearance of metabolites.

1987 • 62 citations

Stereoselective clearance and distribution of intravenous propranolol

1984 • 62 citations

Stereo- and regioselectivity of hepatic oxidation in man ? Effect of the debrisoquine/sparteine phenotype on bufuralol hydroxylation

1986 • 49 citations

The inhibitory effect of propranolol pretreatment on its own metabolism in the rat.

1981 • 45 citations

Effects of cancer and its treatments on plasma concentration of alpha1-acid glycoprotein and propranolol binding

1982 • 40 citations

Stereochemistry of the in vivo disposition and metabolism of propranolol in dog and man using deuterium-labeled pseudoracemates.

1985 • 40 citations

Stereoselective binding of the (-)-enantiomer of propranolol to plasma and extravascular binding sites in the dog.

1983 • 36 citations

Oxidation of (R)- and (S)-propranolol in human and dog liver microsomes. Species differences in stereoselectivity.

1982 • 35 citations

Kinetics and metabolism of (+)-, (?)- and (�)-bufuralol

1982 • 35 citations

Different steric characteristics of ?1- and ?2-adrenoceptors

1984 • 34 citations

STIMULATION INDUCED RELEASE OF PROPRANOLOL AND NOREPINEPHRINE FROM ADRENERGIC NEURONS

1978 • 34 citations

Exercise‐induced increments in plasma levels of propranolol and noradrenaline.

1983 • 34 citations

Adrenergic nerve stimulation-induced release of propranolol from the perfused hindlimb and spleen of the dog and associated changes in postjunctional response.

1983 • 26 citations

Depolarization‐induced release of propranolol and atenolol from rat cortical synaptosomes

1985 • 25 citations

Accumulation, subcellular localization and release of propranolol from synaptosomes of rat cerebral cortex.

1984 • 23 citations

Partial metabolic clearances as determinants of the oral bioavailability of propranolol.

1986 • 23 citations

Stereoselective oxidative metabolism of propranolol in the microsomal fraction from rat and human liver. Use of deuterium labeling and pseudoracemic mixtures.

1986 • 22 citations

Pharmacokinetics and dynamics of penbutolol in humans: Evidence for pathway-specific stereoselective clearance

1986 • 19 citations

Propranolol disposition after acute myocardial infarction

1984 • 17 citations

Stereoselective sulfate conjugation of 4-hydroxypropranolol in vitro by different species.

1985 • 13 citations

Stereoselectivity in the metabolism of the .BETA.-adrenergic blocking agent, (.+-.)-1-tert-butylamino-3-(2,3-dimethylphenoxy)-2-propanol hydrochloride (xibenolol hydrochloride, D-32), in man.

1985 • 13 citations