Pathogenesis of Chagas heart disease: role of autoimmunity

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Autoimmunity in Chagas disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen.

1995 • 226 citations

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1999 • 225 citations

A monoclonal antibody defining antigenic determinants on subpopulations of mammalian neurones and Trypanosoma cruzi parasites

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Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-γ as important determinants of chemokine mRNA expression during infection with

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Myocardial parasite persistence in chronic chagasic patients.

1999 • 166 citations

The functional significance of epitope spreading and its regulation by co‐stimulatory molecules

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Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruzi.

1992 • 162 citations

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1974 • 152 citations

“Autoimmune rejection” of neonatal heart transplants in experimental Chagas disease is a parasite-specific response to infected host tissue

1997 • 148 citations

De Novo Autoimmunity to Cardiac Myosin After Heart Transplantation and Its Contribution to the Rejection Process

1999 • 147 citations

Abnormalities of the Coronary Microcirculation in Acute Murine Chagas' Disease *

1985 • 140 citations

Autoimmunity in Chaga's Disease

1986 • 129 citations

Expression of myosin-class II major histocompatibility complexes in the normal myocardium occurs before induction of autoimmune myocarditis.

1992 • 126 citations

Progress towards interruption of transmission of Chagas disease

1999 • 126 citations

The role of endothelin in the pathogenesis of Chagas’ disease

2001 • 112 citations

Chagasic Cardiopathy

1974 • 110 citations

Coxsackievirus induced myocarditis in mice: cardiac myosin autoantibodies do not cross-react with the virus.

1987 • 103 citations

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1989 • 97 citations

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1985 • 94 citations

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1988 • 88 citations

Parasite polyclonal activators: new targets for vaccination approaches?

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Cardiac Myosin Autoimmunity in Acute Chagas' Heart Disease

2001 • 87 citations

Autoimmunity in Chagas heart disease

2001 • 86 citations

Critical self-epitopes are key to the understanding of self-tolerance and autoimmunity

1999 • 85 citations

Trypanosoma cruziin the Cerebrospinal Fluid during the Acute Stage of Chagas' Disease

1978 • 79 citations

Cardiac antigen-specific autoantibody production is associated with cardiomyopathy in Trypanosoma cruzi-infected mice.

1994 • 74 citations

Comparison between autoantibodies arising during Trypanosoma cruzi infection in mice and natural autoantibodies.

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Is Trypanosoma cruzi a New Threat to Our Blood Supply?

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The causation and importance of nervous lesions in American trypanosomiasis.

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Autoimmunity in heart disease: mechanisms and genetic susceptibility

1996 • 46 citations

Cruzipain induces autoimmune response against skeletal muscle and tissue damage in mice

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Anti-Myosin Humoral Immune Response Following Cardiac Injury

1989 • 43 citations

Trypanosoma cruzi: Cross-reactive anti-heart autoantibodies produced during infection in mice

1989 • 42 citations

Trypanosoma cruziinfection enhances polyreactive antibody response in an acute case of human Chagas' disease

1993 • 41 citations

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1993 • 41 citations

Antiheart antibody-dependent cytotoxicity in the sera of mice chronically infected with Trypanosoma cruzi

1988 • 38 citations

Autoimmunity and Chagas’ Disease

1989 • 38 citations

Prevention of Autoimmune Myocarditis Through the Induction of Antigen-Specific Peripheral Immune Tolerance

2001 • 33 citations

Mimicry in Trypanosoma cruzi: fantasy and reality

1991 • 31 citations

Experimental myocarditis induced in Swiss mice by homologous heart immunization resembles chronic experimental Chagas' heart disease

1984 • 29 citations

Characterization of Autoantibodies Generated in Mice by Immunization with the C-Terminal Region ofTrypanosoma cruziRibosomal P1 and P2 Proteins

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1989 • 8 citations

Autoimmunity in Chagas' disease: immunomodulation of autoimmune and T. cruzi-specific immune responses

1988 • 7 citations