Microchip-based high-throughput screening analysis of combinatorial libraries

The Sequence of the Human Genome

2001 • 13,500 citations

Printing Proteins as Microarrays for High-Throughput Function Determination

2000 • 2,754 citations

Drug Discovery: A Historical Perspective

2000 • 2,654 citations

Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery

2000 • 2,450 citations

Genomics, gene expression and DNA arrays

2000 • 2,039 citations

Global Analysis of Protein Activities Using Proteome Chips

2001 • 1,857 citations

Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

1999 • 1,684 citations

A chemical switch for inhibitor-sensitive alleles of any protein kinase

2000 • 1,032 citations

A microfabricated fluorescence-activated cell sorter

1999 • 868 citations

Analysis of yeast protein kinases using protein chips

2000 • 803 citations

Advances in surface plasmon resonance biosensor analysis

2000 • 627 citations

Protein Microchips: Use for Immunoassay and Enzymatic Reactions

2000 • 524 citations

Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems

2000 • 518 citations

Protein microarrays: prospects and problems

2001 • 467 citations

High-throughput and ultra-high-throughput screening: solution- and cell-based approaches

2000 • 450 citations

Printing Small Molecules as Microarrays and Detecting Protein−Ligand Interactions en Masse

1999 • 424 citations

Transport, Manipulation, and Reaction of Biological Cells On-Chip Using Electrokinetic Effects

1997 • 421 citations

Protein arrays and microarrays

2001 • 355 citations

Bioanalysis in microfluidic devices

2002 • 302 citations

Radial Capillary Array Electrophoresis Microplate and Scanner for High-Performance Nucleic Acid Analysis

1999 • 252 citations

Fabrication of Phospholipid Bilayer-Coated Microchannels for On-Chip Immunoassays

2000 • 243 citations

Flow Cytometry of Escherichia coli on Microfluidic Devices

2001 • 224 citations

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

1999 • 200 citations

Harnessing the Power of the Genome in the Search for New Antibiotics

2000 • 190 citations

Microfabricated electroporation chip for single cell membrane permeabilization

2001 • 181 citations

A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR)

2000 • 171 citations

How many leads from HTS?

1999 • 151 citations

Untitled

1999 • 148 citations

SPOCC: A Resin for Solid-Phase Organic Chemistry and Enzymatic Reactions on Solid Phase

1999 • 129 citations

DNA Microarray Analysis of Complex Biologic Processes

2001 • 114 citations

BADGE, BeadsArray for the Detection of Gene Expression, a High-Throughput Diagnostic Bioassay

2001 • 112 citations

Recent Advances in Chemical Approaches to the Study of Biological Systems

2001 • 110 citations

Designing Small-Molecule Switches for Protein-Protein Interactions

2000 • 91 citations

Parallel Personal Comments on “Classical” Papers in Combinatorial Chemistry

1998 • 90 citations

Detection of Viable Cryptosporidium parvum Using DNA-Modified Liposomes in a Microfluidic Chip

2001 • 79 citations

Assay Miniaturization for Ultra-High Throughput Screening of Combinatorial and Discrete Compound Libraries: A 9600-Well (0.2 Microliter) Assay System

1998 • 73 citations

A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells

1997 • 70 citations

An introduction to arrays

2001 • 59 citations

Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale

1997 • 58 citations

A microfluidics platform for cell fusion

2001 • 53 citations

Integrating Combinatorial Synthesis and Bioassays

2000 • 43 citations

DNA chips: a new tool for genetic analysis and diagnostics

2001 • 41 citations

Parallel reactions in open chip-based nanovials with continuous compensation for solvent evaporation

2000 • 40 citations

Chemical genomics: what will it take and who gets to play?

2001 • 29 citations

Liquid lid for biochemical reactions in chip-based nanovials

2000 • 28 citations

Gel-Immobilized Microarrays of Nucleic Acids and Proteins: Production and Application for Macromolecular Research

2003 • 27 citations

Techniques for analysis and purification in high-throughput chemistry

2001 • 21 citations

High content screening – from cells to data to knowledge

2001 • 17 citations

Target-based discovery of crop protection chemicals

1999 • 16 citations

DNA and Protein Microarrays and their Contributions to Proteomics and Genomics

2001 • 16 citations

Biacore, La Jolla sense new drugs

2001 • 2 citations

Worms supply information about the meaning of DNA sequence

2001 • 2 citations

Mouse cDNA library

2001 • 2 citations