Arcuate Kisspeptin/Neurokinin B/Dynorphin (KNDy) Neurons Mediate the Estrogen Suppression of Gonadotropin Secretion and Body Weight

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1982 • 53,055 citations

AChE-stained horizontal sections of the rat brain in stereotaxic coordinates

1980 • 4,422 citations

TheGPR54Gene as a Regulator of Puberty

2003 • 2,419 citations

Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

2003 • 2,313 citations

Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden.

1984 • 1,702 citations

Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution.

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Increased adipose tissue in male and female estrogen receptor-α knockout mice

2000 • 1,226 citations

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1992 • 1,207 citations

Mice lacking melanin-concentrating hormone are hypophagic and lean

1998 • 1,139 citations

Regulation of Kiss1 Gene Expression in the Brain of the Female Mouse

2005 • 1,038 citations

Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty

2005 • 985 citations

Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology

1986 • 944 citations

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

2008 • 910 citations

Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion

2010 • 721 citations

Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse

2009 • 717 citations

Kisspeptin Neurons in the Arcuate Nucleus of the Ewe Express Both Dynorphin A and Neurokinin B

2007 • 648 citations

Multimodal Influence of Estrogen upon Gonadotropin-Releasing Hormone Neurons

1998 • 592 citations

Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction

2011 • 552 citations

Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat

2010 • 551 citations

Distribution of dynorphin and enkephalin peptides in the rat brain

1986 • 519 citations

Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha

2006 • 487 citations

InactivatingKISS1Mutation and Hypogonadotropic Hypogonadism

2012 • 428 citations

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

2006 • 399 citations

Hypertrophy and Increased Kisspeptin Gene Expression in the Hypothalamic Infundibular Nucleus of Postmenopausal Women and Ovariectomized Monkeys

2007 • 363 citations

Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons

2010 • 312 citations

Pronociceptive Actions of Dynorphin Maintain Chronic Neuropathic Pain

2001 • 299 citations

Neuroendocrine Control of the Ovarian Cycle of the Rat

2006 • 298 citations

Gonad hormone functions, and the reciprocal influence between gonads and hypophysis with its bearing on the problem of sex hormone antagonism

1932 • 296 citations

A simple and sensitive antigen retrieval method for free-floating and slide-mounted tissue sections

1999 • 291 citations

Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells

2010 • 273 citations

Structural Interactions between Kisspeptin and GnRH Neurons in the Mediobasal Hypothalamus of the Male Rhesus Monkey (Macaca mulatta) as Revealed by Double Immunofluorescence and Confocal Microscopy

2008 • 271 citations

Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice

2011 • 268 citations

Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: Morphologic evidence of interrelated function within the arcuate nucleus

2006 • 267 citations

An Increase in Kisspeptin-54 Release Occurs with the Pubertal Increase in Luteinizing Hormone-Releasing Hormone-1 Release in the Stalk-Median Eminence of Female Rhesus Monkeys in Vivo

2008 • 262 citations

Neurokinin B Stimulates GnRH Release in the Male Monkey (Macaca mulatta) and Is Colocalized with Kisspeptin in the Arcuate Nucleus

2010 • 254 citations

Hypertrophy and Increased Gene Expression of Neurons Containing Neurokinin-B and Substance-P Messenger Ribonucleic Acids in the Hypothalami of Postmenopausal Women*

1991 • 248 citations

Kisspeptin Is Essential for the Full Preovulatory LH Surge and Stimulates GnRH Release from the Isolated Ovine Median Eminence

2011 • 239 citations

Evidence That Dynorphin Plays a Major Role in Mediating Progesterone Negative Feedback on Gonadotropin-Releasing Hormone Neurons in Sheep

2004 • 235 citations

Kisspeptin Directly Excites Anorexigenic Proopiomelanocortin Neurons but Inhibits Orexigenic Neuropeptide Y Cells by an Indirect Synaptic Mechanism

2010 • 224 citations

The Role of Kisspeptin–GPR54 Signaling in the Tonic Regulation and Surge Release of Gonadotropin-Releasing Hormone/Luteinizing Hormone

2007 • 221 citations

Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback

2008 • 221 citations

Female reproductive maturation in the absence of kisspeptin/GPR54 signaling

2011 • 207 citations

THE EFFECTS OF OVARIAN STEROIDS ON FOOD AND WATER INTAKE AND BODY WEIGHT IN THE FEMALE RAT

1973 • 202 citations

Morphologic evidence that neurokinin B modulates gonadotropin‐releasing hormone secretion via neurokinin 3 receptors in the rat median eminence

2005 • 193 citations

Neurokinin B and the hypothalamic regulation of reproduction

2010 • 187 citations

Morphological Evidence for Direct Interaction between Arcuate Nucleus Neuropeptide Y (NPY) Neurons and Gonadotropin-Releasing Hormone Neurons and the Possible Involvement of NPY Y1 Receptors1

1999 • 186 citations

Localization of the neuromedin K receptor (NK3) in the central nervous system of the rat

1996 • 177 citations

Neurokinin 3 Receptor Immunoreactivity in the Septal Region, Preoptic Area and Hypothalamus of the Female Sheep: Colocalisation in Neurokinin B Cells of the Arcuate Nucleus but not in Gonadotrophin‐Releasing Hormone Neurones

2009 • 174 citations

Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat

2009 • 173 citations

In situ hybridization analysis of the distribution of neurokinin-3 mRNA in the rat central nervous system

1996 • 165 citations

Projections of Arcuate Nucleus and Rostral Periventricular Kisspeptin Neurons in the Adult Female Mouse Brain

2011 • 152 citations

Association of polymorphisms in the estrogen receptor α gene with body fat distribution

2003 • 151 citations

Postmenopausal Hypertrophy of Neurons Expressing the Estrogen Receptor Gene in the Human Hypothalamus*

1990 • 140 citations

Distribution of neurons expressing neurokinin B in the rat brain: Immunohistochemistry and in situ hybridization

1992 • 138 citations

Sexual dimorphism in the organization of the rat hypothalamic infundibular area

2006 • 134 citations

Neurokinin-3 receptor distribution in rat and human brain: an immunohistochemical study

1999 • 132 citations

Critical Role for Estrogen Receptor alpha in Negative Feedback Regulation of Gonadotropin-Releasing Hormone mRNA Expression in the Female Mouse

2003 • 132 citations

Distribution of the pro-opiomelanocortin derived peptides, adrenocorticotrope hormone, α-melanocyte-stimulating hormone and β-endorphin (ACTH, α-MSH, β-END) in the rat hypothalamus

1985 • 131 citations

KiSS-1 and Reproduction: Focus on Its Role in the Metabolic Regulation of Fertility

2006 • 131 citations

Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty

2009 • 123 citations

Effects of postmenopausal hormone replacement therapy on central abdominal fat, glycemic control, lipid metabolism, and vascular factors in type 2 diabetes: a prospective study.

1999 • 121 citations

Neurokinin B Gene Expression Is Increased in the Arcuate Nucleus of Ovariectomized Rats

1994 • 120 citations

The Inhibitory Effects of Neurokinin B on GnRH Pulse Generator Frequency in the Female Rat

2011 • 111 citations

Uncovering Novel Reproductive Defects in Neurokinin B Receptor Null Mice: Closing the Gap Between Mice and Men

2012 • 110 citations

Localization of the tachykinin neurokinin B precursor peptide in rat brain by immunocytochemistry and in situ hybridization

1992 • 104 citations

Mapping of Kisspeptin Fibres in the Brain of the Pro‐Oestrous Rat

2010 • 101 citations

Fasting Reduces KiSS‐1 Expression in the Anteroventral Periventricular Nucleus (AVPV): Effects of Fasting on the Expression of KiSS‐1 and Neuropeptide Y in the AVPV or Arcuate Nucleus of Female Rats

2008 • 98 citations

Changes in Prodynorphin Gene Expression and Neuronal Morphology in the Hypothalamus of Postmenopausal Women

2008 • 96 citations

The Effects of Hormone Replacement Therapy on Hypothalamic Neuropeptide Gene Expression in a Primate Model of Menopause¹

1999 • 92 citations

Impaired Estrogen Feedback and Infertility in Female Mice with Pituitary-Specific Deletion of Estrogen Receptor Alpha (ESR1)1

2009 • 92 citations

Association of Estrogen Receptor-α Genotypes with Body Mass Index in Normal Healthy Postmenopausal Caucasian Women1

2000 • 91 citations

Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y⁺, proopiomelanocortin⁺, and tyrosine hydroxylase⁺ neurons in neonatal and adult mice

2009 • 84 citations

Regulation of Food Intake and Gonadotropin-Releasing Hormone/Luteinizing Hormone during Lactation: Role of Insulin and Leptin

2009 • 77 citations

Hippocampal injury, atrophy, synaptic reorganization, and epileptogenesis after perforant pathway stimulation‐induced status epilepticus in the mouse

2009 • 76 citations

The Effects of Hormone Replacement Therapy on Hypothalamic Neuropeptide Gene Expression in a Primate Model of Menopause

1999 • 72 citations

Estrogen Regulation of Neurokinin B Gene Expression in the Mouse Arcuate Nucleus Is Mediated by Estrogen Receptor α

2003 • 71 citations

Monoclonal Antibodies to Luteinizing Hormone-Releasing Hormone: Production, Characterization, and Immunocytochemical Application1

1991 • 68 citations

Morphological Evidence for Direct Interaction between Kisspeptin and Gonadotropin-Releasing Hormone Neurons at the Median Eminence of the Male Goat: An Immunoelectron Microscopic Study

2011 • 68 citations

Basomedial Hypothalamic Injections of Neuropeptide Y Conjugated to Saporin Selectively Disrupt Hypothalamic Controls of Food Intake

2004 • 67 citations

Presence of nuclear androgen receptor-like immunoreactivity in neurokinin B-containing neurons of the hypothalamic arcuate nucleus of the adult male rat

1994 • 63 citations

GnRH-Deficient Phenotypes in Humans and Mice with Heterozygous Variants inKISS1/Kiss1

2011 • 62 citations

Effects of Ovariectomy on the Neuroendocrine Axes Regulating Reproduction and Energy Balance in Young Cynomolgus Macaques

2004 • 59 citations

Kisspeptin Directly Regulates Neuropeptide Y Synthesis and Secretion via the ERK1/2 and p38 Mitogen-Activated Protein Kinase Signaling Pathways in NPY-Secreting Hypothalamic Neurons

2010 • 59 citations

Activation of Neurokinin 3 Receptors in the Median Preoptic Nucleus Decreases Core Temperature in the Rat

2011 • 57 citations

Specific agonists for neurokinin B receptors

1987 • 48 citations

Effects of ovariectomy and estradiol on body weight and food intake in gold thioglucose-treated mice

1976 • 47 citations

An Improved Method for Recording Tail Skin Temperature in the Rat Reveals Changes During the Estrous Cycle and Effects of Ovarian Steroids

2010 • 44 citations

Immunocytochemical detection of the neurokinin B receptor (NK3) on melanin-concentrating hormone (MCH) neurons in rat brain

1997 • 35 citations

Characterization of the binding of [125I-iodo-histidyl,methyl-Phe7] neurokinin B to the neurokinin-3 receptor

1993 • 32 citations

Substantial discrepancies in 17β‐oestradiol concentrations obtained with three different commercial direct radioimmunoassay kits in rat sera

2008 • 30 citations

Dynorphin in pro-opiomelanocortin neurons of the hypothalamic arcuate nucleus

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Postmenopausal hypertrophy of neurons expressing the estrogen receptor gene in the human hypothalamus

1991 • 24 citations

INFLUENCE OF REPRODUCTIVE HORMONES UPON GROWTH IN OVARIECTOMIZED AND NORMAL FEMALE RATS

1944 • 22 citations

Entering through the doors of perception: characterization of a highly selective Substance P receptor-targeted toxin

2000 • 7 citations