Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells.

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

The dual effect of membrane potential on sodium conductance in the giant axon of Loligo

1952 • 1,551 citations

Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels

1983 • 1,010 citations

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 • 899 citations

Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells

1983 • 869 citations

Comparative pharmacology of calcium antagonists: Nifedipine, verapamil and diltiazem

1980 • 865 citations

Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state.

1984 • 834 citations

Calcium Channels in Excitable Cell Membranes

1983 • 725 citations

Effects of calcium ions and local anaesthetics on electrical properties of Purkinje fibres

1955 • 708 citations

Lidocaine block of cardiac sodium channels.

1983 • 660 citations

Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors

1972 • 602 citations

Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pH

1975 • 599 citations

Charges and Potentials at the Nerve Surface

1968 • 567 citations

Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

1975 • 387 citations

Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers.

1975 • 320 citations

The pH-dependent rate of action of local anesthetics on the node of Ranvier.

1977 • 274 citations

Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium

1975 • 258 citations

Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle

1977 • 256 citations

Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane?

1982 • 254 citations

Effect of Verapamil on the Normal Action Potential and on a Calcium Dependent Slow Response of Canine Cardiac Purkinje Fibers

1974 • 229 citations

A unitary mechanism of calcium antagonist drug action.

1983 • 214 citations

Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin

1979 • 197 citations

Inhibition of the slow inward current by nifedipine in mammalian ventricular myocardium

1977 • 189 citations

The voltage- and time-dependent effects of (-)-verapamil on the slow inward current in isolated cat ventricular myocardium.

1978 • 176 citations

Ionic currents in single isolated bullfrog atrial cells.

1983 • 170 citations

Specific binding of [3H]nitrendipine to membranes from coronary arteries and heart in relation to pharmacological effects. Paradoxical stimulation by diltiazem

1982 • 158 citations

Calcium-mediated inactivation of the calcium conductance in cesium-loaded frog heart cells.

1984 • 148 citations

Sensitivity to H, Li and Mg ions of the slow inward sodium current in frog atrial fibres

1975 • 143 citations

Evidence for multiple receptor sites within the putative calcium channel

1982 • 134 citations

[3H]-Nitrendipine, a potent calcium antagonist, binds with high affinity to cardiac membranes.

1981 • 129 citations

On the mechanism of slow calcium channel block in heart

1980 • 119 citations

On the mechanism underlying the action of D-600 on slow inward current and tension in mammalian myocardium.

1977 • 116 citations

Nisoldipine: a new, more selective calcium current blocker in cardiac Purkinje fibers.

1982 • 115 citations

Calcium channel block and recovery from block in mammalian ventricular muscle treated with organic channel inhibitors

1982 • 112 citations

Blockade of myocardial slow inward current at low pH

1977 • 90 citations

The rates of interaction of local anesthetics with sodium channels in nerve.

1978 • 89 citations

Inactivation of the sodium permeability in squid giant nerve fibres

1979 • 88 citations

Cardiac contractility and sarcolemmal calcium binding in several cardiac muscle preparations

1981 • 86 citations

Diltiazem and verapamil preferentially block inactivated cardiac calcium channels

1983 • 80 citations

Studies on the inhibitory effect of verapamil on the slow inward current in mammalian ventricular myocardium

1978 • 78 citations

The influence of pH on equilibrium effects of tetrodotoxin on myelinated nerve fibres of Rana esculenta.

1975 • 61 citations

Anesthetics: molecular correlates of voltage- and frequency-dependent sodium channel block in nerve.

1979 • 61 citations

Relationship of binding of a calcium channel blocker to inhibition of contraction in intact cultured embryonic chick ventricular cells.

1983 • 56 citations

Differential effects of tetracaine on delayed potassium channels and displacement currents in frog skeletal muscle.

1976 • 53 citations

Slow inactivation of calcium channels in the cardiac Purkinje fiber

1982 • 47 citations

Voltage-and frequency-dependent block of diltiazem on the slow inward current and generation of tension in frog ventricular muscle

1983 • 43 citations

Effects of diltiazem on transmembrane potential and current of right ventricular papillary muscle of ferrets.

1984 • 33 citations

Extracellular pH selectively modulates recovery from sodium inactivation in frog myelinated nerve

1979 • 20 citations

Does [³H]Nifedipine Label the Calcium Channel in Rabbit Myocardium?

1983 • 14 citations

Voltage clamp comparison of the organic calcium channel blockers D-600 and nisoldipine.

1984 • 4 citations