Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1995 • 1,887 citations

Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

1995 • 1,800 citations

ORL1, a novel member of the opioid receptor family

1994 • 1,060 citations

Physiological properties of unmyelinated fiber projection to the spinal cord

1966 • 836 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists

1992 • 301 citations

Calcium Channels Coupled to Glutamate Release Identified by ω-Aga-IVA

1992 • 292 citations

Molecular Cloning of a Novel G Protein‐Coupled Receptor Related to the Opiate Receptor Family

1995 • 249 citations

Increase by the ORL₁ receptor (opioid receptor‐like₁) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones

1996 • 231 citations

The effect of nociceptin on Ca²⁺ channel current and intracellular Ca²⁺ in the SH‐SY5Y human neuroblastoma cell line

1996 • 208 citations

Structure and Regional Distribution of Nociceptin/Orphanin FQ Precursor

1996 • 148 citations

Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo

1996 • 133 citations

Nociceptin induced inhibition of K⁺ evoked glutamate release from rat cerebrocortical slices

1996 • 128 citations

K‐Opiate Agonists Inhibit Adenylate Cyclase and Produce Heterologous Desensitization in Rat Spinal Cord

1989 • 119 citations

Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro

1996 • 104 citations

Role of the Injury Disharge in the Development of Thermal Hyperesthesia after Sciatic Nerve Constriction Injury in the Rat

1993 • 50 citations

Identification of Dynorphins as Endogenous Ligands for an Opioid Receptor-like Orphan Receptor

1995 • 49 citations

Involvement of N- and non-N-type calcium channels in synaptic transmission at corticostriatal synapses

1994 • 44 citations

Opioid Receptor-Coupled Second Messenger Systems

1993 • 37 citations

Calcium channel blocking agents and potassium-stimulated release of glutamate from cerebellar slices

1992 • 25 citations

Deleted Work

1955 • 0 citations