Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like1 receptor agonist, in the rat formalin test

Chronic catheterization of the spinal subarachnoid space

1976 • 2,244 citations

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1995 • 1,887 citations

Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

1995 • 1,800 citations

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

1982 • 1,160 citations

ORL1, a novel member of the opioid receptor family

1994 • 1,060 citations

Physiological properties of unmyelinated fiber projection to the spinal cord

1966 • 836 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.

1987 • 616 citations

The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury

1992 • 564 citations

Distribution of dynorphin and enkephalin peptides in the rat brain

1986 • 519 citations

Comparison of the Antinociceptive Effects of Pre- and Posttreatment with Intrathecal Morphine and MK801, an NMDA Antagonist, on the Formalin Test in the Rat

1992 • 354 citations

The rat paw formalin test: comparison of noxious agents

1990 • 351 citations

Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat

1990 • 310 citations

Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N- and P-type channels inhibits formalin-induced nociception

1994 • 297 citations

Molecular Cloning of a Novel G Protein‐Coupled Receptor Related to the Opiate Receptor Family

1995 • 249 citations

Increase by the ORL₁ receptor (opioid receptor‐like₁) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones

1996 • 231 citations

The effect of nociceptin on Ca²⁺ channel current and intracellular Ca²⁺ in the SH‐SY5Y human neuroblastoma cell line

1996 • 208 citations

Structure and Regional Distribution of Nociceptin/Orphanin FQ Precursor

1996 • 148 citations

Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation

1991 • 145 citations

Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo

1996 • 133 citations

Stimulus specificity of peripherally evoked substance P release from the rabbit dorsal horn in situ

1989 • 130 citations

Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide

1996 • 122 citations

K‐Opiate Agonists Inhibit Adenylate Cyclase and Produce Heterologous Desensitization in Rat Spinal Cord

1989 • 119 citations

Identification of Dynorphins as Endogenous Ligands for an Opioid Receptor-like Orphan Receptor

1995 • 49 citations

Opioid Receptor-Coupled Second Messenger Systems

1993 • 37 citations

Deleted Work

1955 • 0 citations