Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

1995 • 634 citations

Interleukin 1 signaling occurs exclusively via the type I receptor.

1993 • 609 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release

1998 • 369 citations

Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.

1994 • 340 citations

The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases)

1997 • 311 citations

The glomerular response to injury: Progression or resolution?

1994 • 230 citations

Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells.

1994 • 230 citations

Interleukin 1 signaling occurs exclusively via the typeI receptor

1993 • 228 citations

Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein

1997 • 227 citations

Biologically active lipids are regulators of Rac.GDI complexation.

1993 • 206 citations

Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells

1997 • 177 citations

Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells

1997 • 161 citations

Activation of Mitogen-activated Protein Kinase by Arachidonic Acid in Rat Liver Epithelial WB Cells by a Protein Kinase C-dependent Mechanism

1995 • 116 citations

Residual bodies activate Sertoli cell interleukin-1 alpha (IL-1 alpha) release, which triggers IL-6 production by an autocrine mechanism, through the lipoxygenase pathway.

1995 • 112 citations

Interleukin 1 alpha causes rapid activation of cytosolic phospholipase A2 by phosphorylation in rat mesangial cells.

1994 • 108 citations

Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades

1996 • 106 citations

Relationship between Arachidonate−Phospholipid Remodeling and Apoptosis

1996 • 97 citations

Interleukin-1 alpha stimulates prostaglandin biosynthesis in serum-activated mesangial cells by induction of a non-pancreatic (type II) phospholipase A2

1991 • 96 citations

Activation of extracellular signal-regulated kinase in proliferative glomerulonephritis in rats.

1997 • 79 citations

Arachidonic acid mediates interleukin-1 and tumor necrosis factor-alpha- induced activation of the c-jun amino-terminal kinases in stromal cells

1996 • 65 citations

Dysfunction of glomerular fibrinolysis in experimental antiglomerular basement membrane antibody glomerulonephritis.

1993 • 52 citations

Cytokines, mesangial cell activation and glomerular injury.

1993 • 42 citations

Interleukin-1beta stimulates phospholipase A2 activity in adult rat ventricular myocytes

1997 • 36 citations

Interleukin 1 activates jun N‐terminal kinases JNK1 and JNK2 but not extracellular regulated MAP kinase (ERK) in human glomerular mesangial cells

1996 • 36 citations

Combination of Arachidonic Acid and Guanosine 5′-O-(3-Thiotriphosphate) Induces Translocation of rac p21s to Membrane and Activation of NADPH Oxidase in a Cell-Free System

1993 • 31 citations

Interleukin-1 beta activates c-jun NH2-terminal kinase subgroup of mitogen-activated protein kinases in mesangial cells

1996 • 27 citations

Cytosolic domain of the type I interleukin-1 receptor spontaneously recruits signaling molecules to activate a proinflammatory gene.

1997 • 16 citations

Antisense inhibition of 85-kDa cPLA2 blocks arachidonic acid release from airway epithelial cells

1997 • 15 citations

In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites

1994 • 11 citations

IL-1α increases arachidonyl-COA: Lysophospholipid acyltransferase activity and stimulates [3H] arachidonate incorporation into phospholipids in rat mesangial cells

1992 • 11 citations

Regulation of MAP-Kinase Activation by 8-Iso-Prostaglandin F2a in Cultured Rat Aortic Smooth Muscle Cells

1997 • 4 citations

Cited By (0)

Loading...