Folding of the nascent peptide chain into a biologically active protein

Principles that Govern the Folding of Protein Chains

1973 • 6,771 citations

Are there pathways for protein folding?

1968 • 1,496 citations

Genetic Control of Biochemical Reactions in Neurospora

1941 • 1,310 citations

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

Experimental and Theoretical Aspects of Protein Folding

1975 • 965 citations

THE HEN EGG-WHITE LYSOZYME MOLECULE

1967 • 505 citations

Catalysis of protein folding by prolyl isomerase

1987 • 488 citations

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein

1984 • 485 citations

Quantitation of parameters that determine the rate of ovalbumin synthesis

1975 • 289 citations

Comparison of the transient folding intermediates in lysozyme and .alpha.-lactalbumin

1985 • 281 citations

Antigenic structures of proteins. Their determination has revealed important aspects of immune recognition and generated strategies for synthetic mimicking of protein binding sites

1984 • 245 citations

Folding of Protein Fragments

1981 • 215 citations

Formation of an intrachain disulfide bond on nascent immunoglobulin light chains.

1979 • 199 citations

The efficiency of folding of some proteins is increased by controlled rates of translation in vivo

1987 • 174 citations

Catalysis by protein-disulphide isomerase of the unfolding and refolding of proteins with disulphide bonds

1980 • 173 citations

Relationship between in vivo degradative rates and isoelectric points of proteins.

1975 • 171 citations

NMR studies of the magnesium-ATP binding site of adenylate kinase and of a 45-residue peptide fragment of the enzyme

1985 • 160 citations

Both the Fast and Slow Refolding Reactions of Ribonuclease A Yield Native Enzyme

1973 • 157 citations

Location of the active sites of some enzymes in limited and flexible molecular regions

1986 • 142 citations

The biosynthesis of rat serum albumin. In vivo studies on the formation of the disulfide bonds.

1982 • 124 citations

The design and production of semisynthetic ribonucleases with increased thermostability by incorporation of S‐peptide analogues with enhanced helical stability

1986 • 99 citations

Formation of Randomly Paired Disulfide Bonds in Des-(121–124)-ribonuclease after Reduction and Reoxidation

1970 • 93 citations

Polyribosomes and control of protein synthesis: Effects of sodium fluoride and temperature in reticulocytes

1966 • 78 citations

The second translation of the genetic message: protein folding and assembly

1985 • 77 citations

Seeding protein folding

1986 • 77 citations

Isomerization of proline-93 during the unfolding and refolding of ribonuclease A

1983 • 73 citations

Peptide chain initiation and growth in the induced synthesis of β-galactosidase

1966 • 65 citations

Pathways and mechanisms of protein folding

1984 • 61 citations

Comparison of activity and conformation changes during refolding of urea-denatured creatine kinase

1986 • 61 citations

Removal of the carboxyl-terminal peptide does not affect refolding or function of bacteriorhodopsin as a light-dependent proton pump.

1984 • 45 citations

The reconstitution of denatured phosphoglycerate mutase.

1983 • 42 citations

Kinetic studies of the unfolding-refolding of horse muscle phosphoglycerate kinase induced by guanidine hydrochloride

1985 • 33 citations

Evolution and stability of polypeptide chain conformation: a simulation study

1981 • 28 citations

The complementing fragment-dependent renaturation by enzyme-catalyzed disulfide interchanges of RNase-(1-118) containing non-native disulfide bonds.

1978 • 26 citations

Slow refolding kinetics in yeast iso-2 cytochrome c

1985 • 23 citations

Folding of the polypeptide chain during biosynthesis

1970 • 22 citations

Evidence for the existence of three or more slow phases in the refolding of ribonuclease A and some characteristics of the phases

1987 • 21 citations

Rate enhancement of reconstitution of glyceraldehyde-3-phosphate dehydrogenase by a covalently bound coenzyme analog.

1980 • 20 citations

Denaturation and renaturation of the monomeric phosphoglycerate mutase from Schizosaccharomyces pombe

1987 • 19 citations

Interaction and reconstitution of carboxyl-terminal-shortened B chains with the intact A chain of insulin

1986 • 18 citations

The refolding of denatured rabbit muscle pyruvate kinase

1983 • 14 citations