Antigenic structures of proteins. Their determination has revealed important aspects of immune recognition and generated strategies for synthetic mimicking of protein binding sites

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Prediction of protein antigenic determinants from amino acid sequences.

1981 • 3,715 citations

Prediction of protein conformation

1974 • 3,327 citations

Handbook of Experimental Immunology.

1968 • 2,480 citations

The Antigenic Structure of Proteins: A Reappraisal

1984 • 957 citations

Three-dimensional Fourier Synthesis of Horse Oxyhaemoglobin at 2.8 Å Resolution: The Atomic Model

1968 • 908 citations

Immunogenic structure of the influenza virus hemagglutinin

1982 • 759 citations

A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes.

1978 • 488 citations

Antigenic structure of myoglobin: The complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins

1975 • 474 citations

Three-dimensional fourier synthesis of human deoxyhaemoglobin at 2·5 Å resolution: Refinement of the atomic model

1975 • 431 citations

An examination of conditions for the cleavage of polypeptide chains with cyanogen bromide: Application to catalase

1969 • 287 citations

Opinion

1978 • 283 citations

Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas.

1984 • 272 citations

Antibodies specific for the carboxy- and amino-terminal regions of simian virus 40 large tumor antigen.

1980 • 262 citations

Precise determination of the entire antigenic structure of lysozyme: Molecular features of protein antigenic structures and potential of ‘surface-simulation’ synthesis—a powerful new concept for protein binding sites

1978 • 246 citations

The Three Dimensional Structure of a Combining Region-Ligand Complex of Immunoglobulin NEW at 3.5-Å Resolution

1974 • 227 citations

Immunochemistry of sperm whale myoglobin. I. Specific interaction of some tryptic peptides and of peptides containing all the reactive regions of the antigen

1968 • 200 citations

Antibody to hepatitis B surface antigen after a single inoculation of uncoupled synthetic HBsAg peptides

1982 • 198 citations

Type-specific protective immunity evoked by synthetic peptide of Streptococcus pyogenes M protein

1981 • 186 citations

Anti-influenza response achieved by immunization with a synthetic conjugate.

1982 • 172 citations

The influence of long-range interactions on the structure of myoglobin

1968 • 169 citations

A proposal for the nomenclature of antigenic sites in peptides and proteins

1978 • 166 citations

PERSISTENCE OF IMMUNOGENICITY OF ANTIGEN AFTER UPTAKE BY MACROPHAGES

1968 • 165 citations

Amino Acid Substitution and the Antigenicity of Globular Proteins

1975 • 163 citations

Topographic antigenic determinants recognized by monoclonal antibodies to sperm whale myoglobin.

1982 • 148 citations

Structural basis for the specificity of phosphorylcholine-binding immunoglobulins

1976 • 125 citations

Preparation and properties of an artificial antigen immunologically related to tobacco mosaic virus

1963 • 125 citations

Genetic control of immune response to sperm whale myoglobin in mice. II. T lymphocyte proliferative response to the synthetic antigenic sites.

1979 • 121 citations

Immunochemistry of sperm-whale myoglobins prepared with various modified porphyrins and metalloporphyrins

1967 • 118 citations

Periodate oxidation of sperm-whale myoglobin and the role of the methionine residues in the antigen-antibody reaction

1967 • 115 citations

A novel and comprehensive synthetic approach for the elucidation of protein antigenic structures. Determination of the full antigenic profile of the α-chain of human haemoglobin

1980 • 114 citations

The precise and entire antigenic structure of native lysozyme

1978 • 114 citations

Differences between oestrogen receptor activation by oestrogen and antioestrogen

1981 • 109 citations

Immunochemistry of sperm-whale myoglobin

1973 • 109 citations

On the evolution of myoglobin

1978 • 109 citations

Identification of distinct predominant epitopes recognized by myoglobin-specific T cells under the control of different Ir genes and characterization of representative T cell clones.

1984 • 105 citations

Immunochemistry of sperm-whale myoglobin—XVI: Accurate delineation of the single region in sequence 1–55 by immunochemical studies of synthetic peptides. Some conclusions concerining antigenic structures of proteins

1974 • 104 citations

Topographic determinants on cytochrome c. I. The complete antigenic structures of rabbit, mouse, and guanaco cytochromes c in rabbits and mice1.

1977 • 100 citations

Genetic Control of Immune Response to Sperm Whale Myoglobin in Mice

1979 • 99 citations

Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites

1980 • 96 citations

Properties of different artificial antigens immunologically related to tobacco mosaic virus

1965 • 92 citations

Immunochemistry of sperm whale myoglobin. IV. Role of the arginine residues in the conformation and differentiation of their roles in the antigenic reactivity

1969 • 90 citations

Use of immunoadsorbents for the study of antibody binding to sperm whale myoglobin and its synthetic antigenic sites

1979 • 90 citations

Genetic control of immune response to sperm whale myoglobin in mice. I. T lymphocyte proliferative response under H-2-linked Ir gene control.

1978 • 86 citations

Lack of immunochemical cross-reaction between lysozyme and α-lactalbumin and comparison of their conformations

1970 • 83 citations

Amino Acid Sequence Studies on Bobwhite Quail Egg White Lysozyme

1972 • 83 citations

The T lymphocyte response to cytochrome c. IV. Distinguishable sites on a peptide antigen which affect antigenic strength and memory.

1983 • 81 citations

Structurally inherent antigenic sites. Localization of the antigenic sites of the α-chain of human haemoglobin in three host species by a comprehensive synthetic approach

1982 • 81 citations

Conformational Studies on Modified Proteins and Peptides

1970 • 76 citations

Conformational studies on modified proteins and peptides. Artificial myoglobins prepared with modified and metalloporphyrins

1970 • 75 citations

Immunobiology of Proteins and Peptides VII

1994 • 74 citations

Immunochemistry of sperm whale myoglobin VI. Preparation and conformational analysis of eight mammalian myoglobins

1970 • 74 citations

Enzymic and immunochemical properties of lysozyme

1971 • 72 citations

An immunological approach to the structural relationship between hen egg-white lysozyme and bovine α-lactalbumin

1971 • 71 citations

Localizing antigenic determinants in human haemoglobin with mutants: Molecular correlations of immunological tolerance

1972 • 71 citations

Immunochemistry of sperm whale myoglobin. III. Modification of the three tyrosine residues and their role in the conformation and differentiation of their roles in the antigenic reactivity

1968 • 70 citations

Localization, synthesis, and activity of an antigenic site on influenza virus hemagglutinin.

1983 • 69 citations

Enzymic and immunochemical properties of lysozyme. Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by ‘surface simulation’ synthesis

1977 • 69 citations

Enzymic and immunochemical properties of lysozyme XVI. A novel synthetic approach to an antigenic reactive site by direct linkage of the relevant conformationally adjacent residues constituting the site

1976 • 68 citations

Reconstitution of horse heart cytochrome c: Reformation of the peptide bond linking residues 65 and 66

1974 • 68 citations

Genetic control of the immune response to staphylococcal nuclease. IV. H-2-linked control of the relative proportions of antibodies produced to different determinants of native nuclease.

1977 • 67 citations

Topographic Determinants on Cytochrome c

1977 • 66 citations

Immunochemistry of sperm-whale myoglobin

1974 • 66 citations

The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species

1980 • 65 citations

Delineation of the third antigenic site of lysozyme by application of a novel ‘surface-simulation’ synthetic approach directly linking the conformationally adjacent residues forming the site

1976 • 63 citations

Genetic control of the immune response to myoglobin. IV. Mouse antibodies in outbred and congenic strains against sperm-whale myoglobin recognize the same antigenic sites that are recognized by antibodies raised in other species

1981 • 63 citations

A possible immunodominant epitope recognized by murine T lymphocytes immune to different myoglobins.

1982 • 61 citations

Genetic Control of Immune Response to Sperm Whale Myoglobin in Mice

1978 • 61 citations

Prediction and conformation by synthesis of two antigenic sites in human haemoglobin by extrapolation from the known antigenic structure of sperm-whale myoglobin

1977 • 58 citations

Immunochemical Studies of Hemoglobin and Myoglobin and Their Globin Moieties

1963 • 57 citations

Conformational studies on modified proteins and peptides. II. Conformation of peptides with intact and overlapping helices obtained by cleavage of myoglobin at proline peptide bonds

1970 • 56 citations

How antigenic are antigenic peptides?

1983 • 56 citations

Molecular Localization of the Full Profile of the Continuous Regions Recognized by Myoglobin Primed T-Cells Using Synthetic Overlapping Peptides Encompassing the Entire Molecule

1983 • 56 citations

Immunochemistry of some artificial human hemoglobins

1969 • 55 citations

Immunochemistry of serum albumin. X. five major antigenic sites of human serum albumin are extrapolated from bovine albumin and confirmed by synthetic peptides

1980 • 55 citations

Immunochemistry of sperm-whale myoglobin--XXII. Accurate delineation of the single reactive region in sequence 103-120 by immunochemical studies of synthetic peptides: the complete antigenic structure of the protein.

1975 • 55 citations

The Complete Antigenic Structure of Myoglobin: Approaches and Conclusions for Antigenic Structures of Proteins

1977 • 54 citations

Enzymic and immunochemical properties of lysozyme

1973 • 52 citations

Localization and verification by synthesis of five antigenic sites of bovine serum albumin

1979 • 52 citations

SELF-TOLERANCE AND AUTOIMMUNITY

1976 • 51 citations

Immunochemistry of sperm whale myoglobin VII. Correlation of immunochemical cross-reaction of eight myoglobins with structural similarity and its dependence on conformation

1970 • 48 citations

On topographic antigenic determinants in myoglobins

1980 • 47 citations

Production of Monoclonal Antibodies to Surface Regions that are Non-Immunogenic in a Protein Using Free Synthetic Peptide as Immunogens: Demonstration with Sperm-Whale Myoglobin

1983 • 45 citations

Antibodies with specificities to preselected protein regions evoked by free synthetic peptides representing protein antigenic sites or other surface locations: Demonstration with myoglobin

1983 • 45 citations

Preparation of T-lymphocyte lines and clones with specificities to preselected protein sites by in vitro passage with free synthetic peptides: Demonstration with myoglobin sites

1983 • 44 citations

Antibodies to Sperm-Whale Myoglobin Evoked by Free Synthetic Peptides of an Antigenic Site

1982 • 44 citations

Immunochemistry of sperm-whale myoglobin—XXII

1975 • 43 citations

Immune recognition of serum albumin—XIII. Autoreactivity with rabbit serum albumin of rabbit antibodies against bovine or human serum albumins and autoimmune recognition of rabbit serum albumin

1981 • 42 citations

Production of monoclonal antibodies with preselected submolecular binding specificities to protein antigenic sites: Antibodies to sperm whale myoglobin sites

1983 • 39 citations

Enzymic and immunochemical properties of lysozyme

1977 • 39 citations

Boundary refinement of the lysozyme antigenic site around the disulphide bond 6–127 (site 1) by ‘surface-simulation’ synthesis

1978 • 39 citations

Antigenic structure of sperm whale myoglobin. I. Partition of specificities between antibodies reactive with peptides and native protein.

1982 • 39 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO HEN'S EGG‐WHITE LYSOZYME IN MICE: I. ANTIBODY AND T‐LYMPHOCYTE PROLIFERATIVE RESPONSES TO THE NATIVE PROTEIN*

1979 • 39 citations

The Antigenic Structure of Hen Egg-White Lysozyme: A Model for Disulfide-Containing Proteins

1977 • 37 citations

Genetic Control and Intersite Influences on the Immune Response to Sperm Whale Myoglobin

1982 • 36 citations

Immunochemistry of sperm-whale myoglobin

1973 • 35 citations

Antigenic structure of sperm whale myoglobin. II. Characterization of antibodies preferentially reactive with peptides arising in response to immunization with the native protein.

1982 • 34 citations

Antibodies against protein antigenic sites that are identical in the homologous protein of the immunized animal Autoreactivity in rabbits of antibodies to spermwhale myoglobin

1977 • 34 citations

Production of monoclonal antibodies with pre-selected submolecular binding specificities to protein determinants: Demonstration with sperm whale myoglobin

1982 • 32 citations

Immunochemistry of sperm whale myoglobin. VIII. Specific interaction of peptides obtained by cleavage at proline peptide bonds

1970 • 31 citations

The detection of five antigenically reactive regions in the soybean leghemoglobin a molecule

1978 • 31 citations

Antibodies to a continuous region at residues 38-54 of hen egg white lysozyme found in a small fraction of anti-hen egg white lysozyme antibodies

1980 • 31 citations

Enzymic and immunochemical properties of lysozyme. XIII. Accurate delineation of the reactive site around the disulfide 6-127 by immunochemical study of β-propiolactone lysozyme derivative and of synthetic disulfide peptides

1976 • 30 citations

Chemical Modification and Cleavage of Proteins and Chemical Strategy in Immunochemical Studies of Proteins

1977 • 29 citations

Antibody-combining sites can be mimicked synthetically. Surface-simulation synthesis of the immunoglobulin new combining site to the gamma-hydroxyl derivative of vitamin K1

1978 • 27 citations

Distance calculation of residues neighbouring to lysozyme antigenic sites. Site-neighbouring residues whose evolutionary substitution can modify the characteristics and binding energy of the sites

1980 • 27 citations

Genetic control of the immune response to staphylococcal nuclease. VII. Role of non-H-2-linked genes in the control of the anti-nuclease antibody response

1978 • 27 citations

Molecular basis of the antigenic difference between two closely related lysozymes of known sequence: effect of internal substitutions

1974 • 27 citations

Nearest-neighbour analysis of myoglobin antigenic sites. Nearest-neighbour residues whose replacement can alter the environment of binding-site residue(s) and thus change their characteristics and binding capability

1980 • 26 citations

Production of autoantibodies by immunization with rabbit myoglobin

1978 • 26 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN: III. VARIANT A_β (bm 12) BUT NOT A_e (D2.GD) Ia POLYPEPTIDES ALTER IMMUNE RESPONSIVENESS TOWARDS THE α‐SUBUNIT OF HUMAN HAEMOGLOBIN

1981 • 26 citations

Enzymic and immunochemical properties of lysozyme

1975 • 25 citations

Immune recognition of cytochrome c. I. Investigation by synthesis whether antigenic sites of polymeric cytochrome coincide with locations of sequence differences between the immunizing and host cytochromes

1981 • 25 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN: I. DEMONSTRATION OF SEPARATE GENETIC CONTROL OF THE RESPONSES TO THE α‐ AND β‐SUBUNITS BY IN VITRO LYMPHOCYTE PROLIFERATION

1981 • 24 citations

Immune recognition of serum albumin. 15

1982 • 23 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN:.

1981 • 23 citations

Can an antibody-combining site be mimicked synthetically? The possible surface simulation synthesis of two antibody-combining sites complementary to two antigenic sites of lysozyme.

1977 • 23 citations

Immune recognition of serum albumin. 11. Mouse antibodies against bovine serum albumin recognize the same antigenic sites that are recognized by rabbit antibodies

1980 • 22 citations

Properties of goat anti-human hemoglobin antibodies fractionated on subunit affinity columns

1976 • 22 citations

The primary structure of the myoglobin of rabbit (Oryctolagus cuniculus)

1976 • 21 citations

Antibodies with Preselected Specificities to Protein Regions Evoked by Immunization with Free Synthetic Peptides: Dose Response to Myoglobin Antigenic Sites Reveal an Optimum Dose for Each Antigenic Site

1983 • 20 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO MYOGLOBIN: IX. OVERCOMING GENETIC CONTROL OF ANTIBODY RESPONSE TO ANTIGENIC SITES BY INCREASING THE DOSE OF ANTIGEN USED IN IMMUNIZATION

1982 • 20 citations

Determination of the Entire Antigenic Structure of Native Lysozyme by Surface-Simulation Synthesis, A Novel Concept in Molecular Recognitio

1979 • 19 citations

Cyanogen bromide treatment of N-acetylmethionyl residues without cleavage

1974 • 19 citations

Antigenic determinants of influenza virus hemagglutinin—IX. The carbohydrate side chains from an Asian strain

1982 • 19 citations

The Evolution of Proteins

1973 • 19 citations

First Consequences of the Determination of the Entire Antigenic Structure of Sperm-Whale Myoglobin

1978 • 18 citations

Immunochemistry of sperm-whale myoglobin—XXI

1975 • 17 citations

Influence of Conformation on Immunochemical Properties of Proteins

1977 • 17 citations

Conformation-specific antibodies to the alpha chain COOH terminus of hemoglobin A0.

1979 • 17 citations

T‐LYMPHOCYTE RECOGNITION OF SPERM‐WHALE MYOGLOBIN. SPECIFICITY OF T‐CELL RECOGNITION FOLLOWING NEONATAL TOLERANCE WITH EITHER MYOGLOBIN OR SYNTHETIC PEPTIDES OF AN ANTIGENIC SITE

1983 • 17 citations

Immunochemistry of sperm whale myoglobin. X. Regions responsible for immunochemical cross-reaction with finback whale myoglobin. General conclusions concerning immunochemical cross-reaction of proteins

1971 • 17 citations

Conformational Integrity of Myoglobin after Immunization with Freund's Adjuvant

1977 • 14 citations

Antibody combining sites can be mimicked synthetically. Surface-simulation synthesis of the phosphorylcholine-combining site of myeloma protein M-603

1980 • 14 citations

The Antigenic Structure of Proteins: A Reappraisal

1984 • 13 citations

Immune recognition of serum albumin—XIV. Cross-reactivity by T-lymphocyte proliferation of subdomains 3, 6 and 9 of bovine serum albumin

1982 • 13 citations

The Antigenic Structure of Myoglobin and Initial Consequences of Its Precise Determinatio

1979 • 12 citations

Genetic control of the immune response to myoglobin. 3. Autoimmune T-lymphocyte proliferative response to mouse myoglobin

1980 • 12 citations

The Precise and Entire Antigenic Structure of Lysozyme: Implications of Surface-Simulation Synthesis and the Molecular Features of Protein Antigenic Sites

1978 • 12 citations

Genetic Control of the Immune Response to Myoglobin. V. Analysis of the Cross-Reactivity of 12 Myoglobins with Sperm-Whale Myoglobin Antisera of Inbred Mouse Strains in Terms of Substitutions in the Antigenic Sites and in the Environmental Residues of the Sites

1981 • 8 citations

Time-dependence study of the antibody response to sperm-whale myoglobin: Recognition of the antigenic sites is unaltered over an extended period of immunization

1981 • 7 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN

1984 • 7 citations

Immune recognition of serum albumin. XVI. role of adjuvant in the autoimmune response to mouse serum albumin

1982 • 6 citations

Binding with lysozyme of antibodies against surface-simulation peptides representing the lysozyme antigenic sites

1982 • 6 citations

Identifying Antigenic Determinants on Cytochrome c for B and T Cells

1978 • 6 citations

Genetic Control of the Immune Response to Myoglobin. VII. Antibody Responses to Myoglobin Variants Reveal that Gene Restriction of the Antibody Responses to Myoglobin Antigenic Sites is Dependent on the Chemical Properties of the Sites

1981 • 5 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO MYOGLOBIN: XVI. CONTROL OF ANTIBODIES WITH PRESELECTED SPECIFICITIES FOLLOWING IMMUNIZATION WITH FREE SYNTHETIC PEPTIDES REPRESENTING THE ANTIGENIC SITES OR SURFACE NON‐IMMUNOGENIC LOCATIONS IN THE PROTEIN

1983 • 5 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE TO MYOGLOBIN: VIII. CONTROL OF ANTIBODY AFFINITY

1981 • 5 citations

3 たん白質の化学的断片化

1974 • 1 citations