The Role of Perisynaptic Glial Sheaths in Glutamate Spillover and Extracellular Ca2+ Depletion

Tripartite synapses: glia, the unacknowledged partner

1999 • 2,319 citations

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

1994 • 988 citations

Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations

1995 • 884 citations

Three-Dimensional Relationships between Hippocampal Synapses and Astrocytes

1999 • 844 citations

Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus

1998 • 798 citations

Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus.

1993 • 729 citations

Different modes of expression of AMPA and NMDA receptors in hippocampal synapses

1999 • 673 citations

The Number of Glutamate Transporter Subtype Molecules at Glutamatergic Synapses: Chemical and Stereological Quantification in Young Adult Rat Brain

1998 • 666 citations

Transmitter timecourse in the synaptic cleft: its role in central synaptic function

1996 • 599 citations

Physiological properties of glial cells in the central nervous system of amphibia.

1966 • 594 citations

Three-Dimensional Structure and Composition of CA3→CA1 Axons in Rat Hippocampal Slices: Implications for Presynaptic Connectivity and Compartmentalization

1998 • 500 citations

Transporters Buffer Synaptically Released Glutamate on a Submillisecond Time Scale

1997 • 471 citations

Extrasynaptic Glutamate Diffusion in the Hippocampus: Ultrastructural Constraints, Uptake, and Receptor Activation

1998 • 437 citations

Extrasynaptic Glutamate Spillover in the Hippocampus: Dependence on Temperature and the Role of Active Glutamate Uptake

1997 • 425 citations

Real-time measurement of transmitter release from single synaptic vesicles

1995 • 404 citations

NMDA channel behavior depends on agonist affinity

1992 • 401 citations

Kinetics of a human glutamate transporter

1995 • 401 citations

Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells

1994 • 361 citations

Spillover-Mediated Transmission at Inhibitory Synapses Promoted by High Affinity α6 Subunit GABAA Receptors and Glomerular Geometry

1998 • 345 citations

Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated

1999 • 321 citations

Calcium dynamics associated with a single action potential in a CNS presynaptic terminal

1997 • 298 citations

NMDA Receptor Content of Synapses in Stratum Radiatum of the Hippocampal CA1 Area

2000 • 294 citations

Glial Contribution to Glutamate Uptake at Schaffer Collateral–Commissural Synapses in the Hippocampus

1998 • 289 citations

Analysis of calcium channels in single spines using optical fluctuation analysis

2000 • 268 citations

Miniature endplate current rise times less than 100 microseconds from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle.

1996 • 268 citations

Calcium and potassium changes in extracellular microenvironment of cat cerebellar cortex

1978 • 268 citations

Three-Dimensional analysis of dendritic spines

1983 • 265 citations

Glutamate spillover suppresses inhibition by activating presynaptic mGluRs

2000 • 246 citations

Prolonged Synaptic Currents and Glutamate Spillover at the Parallel Fiber to Stellate Cell Synapse

2000 • 229 citations

Glutamate Spillover Mediates Excitatory Transmission in the Rat Olfactory Bulb

1999 • 226 citations

Monte Carlo simulation of miniature endplate current generation in the vertebrate neuromuscular junction

1991 • 217 citations

Three-dimensional analysis of dendritic spines

1985 • 184 citations

Anion Currents and Predicted Glutamate Flux through a Neuronal Glutamate Transporter

1998 • 179 citations

Geometric and viscous components of the tortuosity of the extracellular space in the brain

1998 • 178 citations

Calcium ions as extracellular messengers

1995 • 176 citations

Fast Removal of Synaptic Glutamate by Postsynaptic Transporters

2000 • 173 citations

Stimulus- and amino acid-induced calcium and potassium changes in rat neocortex

1985 • 171 citations

Interaction between diffusion and Michaelis-Menten uptake of dopamine after iontophoresis in striatum

1995 • 170 citations

Isolation of Current Components and Partial Reaction Cycles in the Glial Glutamate Transporter EAAT2

2000 • 168 citations

Reduction of K⁺Uptake in Glia Prevents Long-Term Depression Maintenance and Causes Epileptiform Activity

1997 • 166 citations

Depletion of calcium in the synaptic cleft of a calyx‐type synapse in the rat brainstem

1999 • 136 citations

GABA Spillover from Single Inhibitory Axons Suppresses Low-Frequency Excitatory Transmission at the Cerebellar Glomerulus

2000 • 132 citations

Calcium Dynamics in the Extracellular Space of Mammalian Neural Tissue

1999 • 132 citations

Optical Measurement of Presynaptic Calcium Currents

1998 • 129 citations

Hippocampal synapses: do they talk to their neighbours?

1999 • 123 citations

Localization of individual calcium channels at the release face of a presynaptic nerve terminal

1994 • 122 citations

Monte Carlo simulation of fast excitatory synaptic transmission at a hippocampal synapse

1996 • 118 citations

Chapter 10: Do astrocytes process neural information?

1992 • 116 citations

Substrate Turnover by Transporters Curtails Synaptic Glutamate Transients

1999 • 102 citations

Ultrastructural synaptic correlates of spatial learning in rat hippocampus

1997 • 101 citations

Pharmacological and functional characterization of astrocytic GABA transport: a short review.

2000 • 85 citations

Linearized models of calcium dynamics: formal equivalence to the cable equation

1994 • 84 citations

Synapses in hippocampus occupy only 1–2% of cell membranes and are spaced less than half-micron apart: a quantitative ultrastructural analysis with discussion of physiological implications

1998 • 82 citations

Assessment of frequency-dependent alterations in the level of extracellular Ca2+ in the synaptic cleft

1997 • 82 citations

Modulation of extracellular calcium and its functional implications.

1980 • 78 citations

Transmitter concentration profiles in the synaptic cleft: an analytical model of release and diffusion

1996 • 76 citations

The effects of geometrical parameters on synaptic transmission: a Monte Carlo simulation study

1997 • 65 citations

A mathematical description of miniature postsynaptic current generation at central nervous system synapses

1996 • 52 citations

Presynaptic Calcium Channels and the Depletion of Synaptic Cleft Calcium Ions

2000 • 48 citations

Astrocytes, oligodendroglia, extracellular space volume and geometry in rat fetal brain grafts

1999 • 44 citations

Computational Properties of Peri-Dendritic Calcium Fluctuations

1998 • 39 citations

Glial K⁺ Permeability and CNS K⁺ Clearance by Diffusion and Spatial Buffering

1991 • 36 citations

The resource consumption principle: attention and memory in volumes of neural tissue.

1996 • 35 citations

Stochastic Model of Central Synapses: Slow Diffusion of Transmitter Interacting with Spatially Distributed Receptors and Transporters

1999 • 34 citations

Calcium diffusion in the brain cell microenvironment

1987 • 32 citations

Laminar profiles of the changes in extracellular calcium concentration induced by repetitive stimulation and excitatory amino acids in the rat dentate gyrus

1986 • 30 citations

Freeze-fracture scanning electron microscopy and comparative freeze-etching study of parallel fiber-Purkinje spine synapses of vertebrate cerebellar cortex.

1990 • 8 citations

Conventional and high resolution scanning electron microscopy and cryofracture techniques as tools for tracing cerebellar short intracortical circuits.

1994 • 3 citations