Substrate Turnover by Transporters Curtails Synaptic Glutamate Transients

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

1994 • 988 citations

Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptors

1998 • 880 citations

Flux coupling in a neuronal glutamate transporter

1996 • 835 citations

Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake

1990 • 728 citations

The Number of Glutamate Transporter Subtype Molecules at Glutamatergic Synapses: Chemical and Stereological Quantification in Young Adult Rat Brain

1998 • 666 citations

Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors

1990 • 649 citations

dl-threo-β-Benzyloxyaspartate, A Potent Blocker of Excitatory Amino Acid Transporters

1998 • 545 citations

Ion fluxes associated with excitatory amino acid transport

1995 • 544 citations

Transporters Buffer Synaptically Released Glutamate on a Submillisecond Time Scale

1997 • 471 citations

Glutamate receptor desensitization and its role in synaptic transmission

1989 • 459 citations

Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells

1987 • 430 citations

Kinetics of a human glutamate transporter

1995 • 401 citations

NMDA channel behavior depends on agonist affinity

1992 • 401 citations

Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells

1994 • 361 citations

Glial contributions to excitatory neurotransmission in cultured hippocampal cells

1994 • 349 citations

Block of glutamate transporters potentiates postsynaptic excitation

1994 • 345 citations

Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin

1999 • 311 citations

Asynchronous release of synaptic vesicles determines the time course of the AMPA receptor-mediated EPSC

1995 • 310 citations

Glial Contribution to Glutamate Uptake at Schaffer Collateral–Commissural Synapses in the Hippocampus

1998 • 289 citations

Macroscopic and Microscopic Properties of a Cloned Glutamate Transporter/Chloride Channel

1998 • 279 citations

Post‐synaptic potentiation: interaction between quanta of acetylcholine at the skeletal neuromuscular synapse.

1975 • 259 citations

Electrogenic properties of the cloned Na+/glucose cotransporter: I. Voltage-clamp studies

1992 • 251 citations

Delayed clearance of transmitter and the role of glutamate transporters at synapses with multiple release sites

1996 • 235 citations

Rapid desensitization of glutamate receptors in vertebrate central neurons.

1988 • 205 citations

Electrogenic uptake of glutamate and aspartate into glial cells isolated from the salamander (Ambystoma) retina.

1991 • 194 citations

Binding order of substrates to the (sodium + potassium ion)-coupled L-glutamic acid transporter from rat brain

1982 • 184 citations

Anion Currents and Predicted Glutamate Flux through a Neuronal Glutamate Transporter

1998 • 179 citations

Glutamate uptake from the synaptic cleft does not shape the decay of the non-NMDA component of the synaptic current

1993 • 170 citations

Pre- and postsynaptic determinants of EPSC waveform at cerebellar climbing fiber and parallel fiber to Purkinje cell synapses

1995 • 167 citations

Passive and synaptic properties of hippocampal neurons grown in microcultures and in mass cultures

1995 • 161 citations

Defining Affinity with the GABA_AReceptor

1998 • 156 citations

The uptake inhibitor L-trans-PDC enhances responses to glutamate but fails to alter the kinetics of excitatory synaptic currents in the hippocampus

1993 • 148 citations

Neuronal Expression of the Glutamate Transporter GLT-1 in Hippocampal Microcultures

1998 • 141 citations

Permeation Properties of Neurotransmitter Transporters

1994 • 140 citations

Retinal glial cell glutamate transporter is coupled to an anionic conductance.

1996 • 132 citations

Direct Evidence For Diazepam Modulation of GABA A Receptor Microscopic Affinity

1996 • 118 citations

Anion Conductance Behavior of the Glutamate Uptake Carrier in Salamander Retinal Glial Cells

1996 • 118 citations

A Reentrant Loop Domain in the Glutamate Carrier EAAT1 Participates in Substrate Binding and Translocation

1998 • 111 citations

Prolonged Physiological Entrapment of Glutamate in the Synaptic Cleft of Cerebellar Unipolar Brush Cells

1997 • 109 citations

The Competitive Transport Inhibitor L‐trans‐pyrrolidine‐2,4‐dicarboxylate Triggers Excitotoxicity in Rat Cortical Neuron‐Astrocyte Co‐cultures via Glutamate Release rather than Uptake Inhibition

1996 • 105 citations

The glutamate uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylate depresses excitatory synaptic transmission via a presynaptic mechanism in cultured hippocampal neurons

1994 • 103 citations

Presynaptic influence on the time course of fast excitatory synaptic currents in cultured hippocampal cells

1995 • 93 citations

Rapid desensitization of glutamate receptors in vertebrate central neurons.

1988 • 75 citations

[29] High-level expression and detection of ion channels in Xenopus oocytes

1998 • 73 citations

New β-Hydroxyaspartate Derivatives Are Competitive Blockers for the Bovine Glutamate/Aspartate Transporter

1997 • 72 citations

Efflux of L-glutamate by synaptic plasma membrane vesicles isolated from rat brain

1982 • 59 citations

Pharmacological characterization of a cloned rat glutamate transporter (GluT-1)

1994 • 26 citations

Rapid desensitization of glutamate receptors in vertebrate central neurons.

1988 • 14 citations