Regulation of apoptosis resistance and ontogeny of age-dependent diseases

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria

1993 • 1,033 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Molecular regulation of apoptosis: Genetic controls on cell death

1993 • 923 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Replicative Senescence: the Human Fibroblast Comes of Age

1990 • 649 citations

Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview

1992 • 600 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Apoptosis-the molecular basis of cell death

1992 • 517 citations

Repression of c- fos Transcription and an Altered Genetic Program in Senescent Human Fibroblasts

1990 • 478 citations

Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved.

1995 • 478 citations

Replicative Senescence: An Old Lives' Tale?

1996 • 429 citations

Apoptosis: The Molecular Basis of Cell Death

1991 • 425 citations

Failure to Phosphorylate the Retinoblastoma Gene Product in Senescent Human Fibroblasts

1990 • 367 citations

Depolymerization of F-actin by deoxyribonuclease I

1976 • 261 citations

Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle.

1992 • 245 citations

Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.

1995 • 242 citations

Identification of Actin as a Substrate of ICE and an ICE-like Protease and Involvement of an ICE-like Protease but Not ICE in Vp-16-Induced U937 Apoptosis

1995 • 210 citations

Death by suicide: one way to go in mammalian cellular development?

1991 • 167 citations

p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin.

1995 • 167 citations

Contractile proteins

1975 • 153 citations

A Specific 1:1 G‐actin: DNAase I complex formed by the action of DNAase I on F‐actin

1975 • 153 citations

Cells en route to apoptosis are characterized by the upregulation of c‐fos, c‐myc, c‐jun, cdc2, and RB phosphorylation, resembling events of early cell‐cycle traverse

1995 • 144 citations

Programmed cell death and apoptosis

1991 • 115 citations

Is there a role for actin in virus budding?

1977 • 112 citations

Involvement of contractile proteins in the changes in consistency of oocyte nucleoplasm of the newt Pleurodeles waltlii.

1981 • 94 citations

The presence of actin in enveloped viruses

1976 • 91 citations

Overexpression of deoxyribonuclease I (DNase I) transfected into COS-cells: its distribution during apoptotic cell death.

1993 • 76 citations

A Unifying Hypothesis To Explain the Retardation of Aging and Tumorigenesis by Caloric Restriction

1995 • 64 citations

Purification, Morphology and Antigenic Characterization of Measles Virus Envelope Components

1984 • 63 citations

The presence of actin in nuclei: a critical appraisal

1977 • 59 citations

Purification from Crude Extract by Affinity Chromatography of the Inhibitor of Deoxyribonuclease I

1971 • 54 citations

Binding of deoxyribonuclease I to actin: a new way to visualize microfilament bundles in nonmuscle cells.

1978 • 51 citations

Death Gives Birth to the Nervous System. But How?

1993 • 41 citations

Actin filaments in paramyxovirus-infected human fibroblasts studied by indirect immunofluorescence

1978 • 39 citations

Commitment to Cell Death Is Signaled by the Appearance of a Terminin Protein of 30 kDa

1994 • 37 citations

Immunochemical localization of contractile proteins in mammalian meiotic chromosomes

1980 • 32 citations

Transitional mucosa in human colorectal lesions

1990 • 24 citations

Mucosal field change in colorectal cancer

1987 • 19 citations

Isolation and Immunological Characterization of the Nucleocapsid and Membrane Proteins of Measles Virus

1980 • 18 citations

Replication of poliovirus and measles virus in cultures of human lymphoblastoid and of burkitt lymphoma cell lines

1981 • 13 citations

Down‐regulation of statin, a nonproliferation‐specific nuclear protein, and up‐regulation of c‐myc after initiation of programmed cell death in mouse fibroblasts

1995 • 12 citations

Characterization of senescence- and apoptosis-dependent forms of terminin as derived from a precursor found in replicating and nonreplicating cells

1996 • 8 citations

Phase-dependent polymerization and depolymerization of actin in physarum polycephalum nuclei

1984 • 4 citations