Ultrastructural alterations induced by 1-methyl-4-phenylpyridinium (MPP+) in canine substantia nigra and rat mesencephalon in vitro

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1984 • 1,007 citations

Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice

1984 • 1,005 citations

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

1984 • 772 citations

1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

1984 • 423 citations

Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys

1984 • 323 citations

Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

1985 • 290 citations

Selectivity of the Parkinsonian Neurotoxin MPTP: Toxic Metabolite MPP ⁺ Binds to Neuromelanin

1986 • 289 citations

Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes

1985 • 270 citations

Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism

1986 • 250 citations

IV. MPTP, MPP+ and mitochondrial function

1987 • 249 citations

Neurochemical and behavioral effects of systematic and intranigral administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the rat

1984 • 221 citations

IV. Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects

1985 • 210 citations

Evidence for neuromelanin involvement in MPTP-induced neurotoxicity

1987 • 120 citations

1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Destroys Dopamine Neurons in Explants of Rat Embryo Mesencephalon

1984 • 113 citations

Dopamine uptake blockers protect against the dopamine depleting effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum

1985 • 110 citations

Dopaminergic toxicity after the stereotaxic administration of the 1-methyl-4-phenylpyridinium ion (MPP+) to rats

1985 • 88 citations

1-methyl-4-phenylpyridine (MPP+) is toxic to mesencephalic dopamine neurons in culture

1985 • 83 citations

The development of the dog nigrostriatal system in organotypic culture

1981 • 30 citations

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