Increase of Circulating CD4+CD25highFoxp3+ Regulatory T Cells in Patients With Metastatic Renal Cell Carcinoma During Treatment With Dendritic Cell Vaccination and Low-Dose Interleukin-2

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

How regulatory T cells work

2008 • 3,048 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

2007 • 1,446 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Intratumoral Balance of Regulatory and Cytotoxic T Cells Is Associated With Prognosis of Hepatocellular Carcinoma After Resection

2007 • 1,060 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

2005 • 878 citations

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

2007 • 836 citations

Tolerance, not immunity, crucially depends on IL-2

2004 • 826 citations

Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions

2006 • 746 citations

Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype

2007 • 730 citations

Regulatory T cells in cancer

2006 • 717 citations

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

2006 • 712 citations

IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients

2005 • 602 citations

The Expression of the Regulatory T Cell–Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in Ovarian Cancer

2005 • 494 citations

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

2006 • 474 citations

Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans

2004 • 415 citations

Cutting Edge: TGF-β Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells

2004 • 395 citations

Human CD4+CD25+ regulatory T cells

2004 • 389 citations

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells

2005 • 378 citations

Characterization of CD4⁺CD25⁺ Regulatory T Cells in Patients Treated With High-Dose Interleukin-2 for Metastatic Melanoma or Renal Cell Carcinoma

2006 • 348 citations

Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients

2006 • 302 citations

IL-21 Enhances and Sustains CD8+ T Cell Responses to Achieve Durable Tumor Immunity: Comparative Evaluation of IL-2, IL-15, and IL-21

2004 • 259 citations

Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period

2005 • 237 citations

Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells

2007 • 227 citations

Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival

2007 • 191 citations

Impact of Cytokine Administration on the Generation of Antitumor Reactivity in Patients with Metastatic Melanoma Receiving a Peptide Vaccine

1999 • 188 citations

An Open-Label, Two-Arm, Phase I Trial of Recombinant Human Interleukin-21 in Patients with Metastatic Melanoma

2007 • 160 citations

Immunologic and Clinical Outcomes of Vaccination With a Multiepitope Melanoma Peptide Vaccine Plus Low-Dose Interleukin-2 Administered Either Concurrently or on a Delayed Schedule

2004 • 149 citations

Interleukin-2: Clinical applications

2002 • 145 citations

CD49d provides access to “untouched” human Foxp3+ Treg free of contaminating effector cells

2008 • 144 citations

IL-21–mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes

2007 • 144 citations

Induction of FOXP3‐expressing regulatory CD4^pos T cells by human mature autologous dendritic cells

2004 • 135 citations

Therapeutic Dendritic Cell Vaccination of Patients With Metastatic Renal Cell Carcinoma

2008 • 95 citations

Interleukin-21 Signaling: Functions in Cancer and Autoimmunity

2007 • 85 citations

Increased Intratumoral FOXP3-positive Regulatory Immune Cells during Interleukin-2 Treatment in Metastatic Renal Cell Carcinoma

2009 • 84 citations

Effects of the Administration of High-Dose Interleukin-2 on Immunoregulatory Cell Subsets in Patients with Advanced Melanoma and Renal Cell Cancer

2007 • 75 citations

In vitro studies with bendamustine: Enhanced activity in combination with rituximab

2002 • 73 citations

Intra-tumoural regulatory T cells: A potential new target in cancer immunotherapy

2006 • 69 citations

Therapeutic Dendritic Cell Vaccination of Patients with Renal Cell Carcinoma

2006 • 56 citations