A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Methods in yeast genetics

1979 • 7,824 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Methods in Yeast Genetics

1988 • 4,905 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity

1974 • 1,532 citations

Yeast transformation: a model system for the study of recombination.

1981 • 1,491 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene

1982 • 1,406 citations

Amino Acid Preferences for Specific Locations at the Ends of α Helices

1988 • 1,356 citations

Principles of protein structure

1980 • 1,094 citations

DNA sequence required for efficient transcription termination in yeast

1982 • 1,014 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

PRE-mRNA SPLICING

1986 • 673 citations

A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases

1988 • 602 citations

GTP-binding domain: three consensus sequence elements with distinct spacing.

1987 • 602 citations

The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro

1983 • 593 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes

1987 • 530 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA

1987 • 508 citations

Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

1989 • 474 citations

A multicomponent complex is involved in the splicing of messenger RNA precursors

1985 • 451 citations

ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors.

1985 • 404 citations

The 5′ terminus of the RNA moiety of U1 small nuclear ribonucleoprotein particles is required for the splicing of messenger RNA precursors

1984 • 404 citations

Spliceosome assembly in yeast.

1987 • 402 citations

Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts

1983 • 396 citations

Genetic map of Saccharomyces cerevisiae

1980 • 394 citations

Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing

1989 • 391 citations

Lariat structures are in vivo intermediates in yeast pre-mRNA splicing

1984 • 379 citations

Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae.

1985 • 342 citations

Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast

1984 • 339 citations

5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements.

1988 • 307 citations

RNA helicase activity associated with the human p68 protein

1989 • 307 citations

Multiple DNA-pRotein Interactions Governing High-Precision DNA Transactions

1986 • 302 citations

Functions of the Abundant U-snRNPs

1988 • 284 citations

Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes

1986 • 283 citations

Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

1988 • 278 citations

Genetic map of Saccharomyces cerevisiae, edition 10

1989 • 276 citations

An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly.

1987 • 272 citations

An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly

1988 • 271 citations

Cap-Binding Proteins of Eukaryotic Messenger RNA: Functions in Initiation and Control of Translation

1988 • 266 citations

A comparison of yeast ribosomal protein gene DNA sequences

1984 • 256 citations

Signals for the selection of a splice site in pre-mRNA

1987 • 247 citations

Refined structure of porcine cytosolic adenylate kinase at 2.1 Å resolution

1988 • 243 citations

Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit β-globin gene

1983 • 235 citations

Mutations in conserved intron sequences affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome.

1986 • 215 citations

Mitochondrial splicing requires a protein from a novel helicase family

1989 • 212 citations

RNA-stimulated ATPase activity of eukaryotic initiation factors.

1984 • 211 citations

The ATP-dependent interaction of eukaryotic initiation factors with mRNA.

1987 • 209 citations

Pre-mRNA Splicing in Yeast

1989 • 209 citations

5′ cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5′ splice region, not by the conserved 5′ GU

1987 • 206 citations

Nuclear protein with sequence homology to translation initiation factor eIF-4A

1988 • 190 citations

Ribosomal Discrimination of tRNAs

1971 • 188 citations

Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing

1985 • 180 citations

EFTu provides an internal kinetic standard for translational accuracy

1988 • 176 citations

An eIF-4A-like protein is a suppressor of an Escherichia coli mutant defective in 50S ribosomal subunit assembly

1988 • 162 citations

Cloning of eukaryotic protein synthesis initiation factor genes: isolation and characterization of cDNA clones encoding factor eIF-4A

1985 • 157 citations

Mutations in a yeast intron demonstrate the importance of specific conserved nucleotides for the two stages of nuclear mRNA splicing

1986 • 150 citations

Early commitment of yeast pre-mRNA to the spliceosome pathway.

1988 • 143 citations

Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes.

1987 • 143 citations

Polypeptide chain elongation factor 1 alpha (EF-1 alpha) from yeast: nucleotide sequence of one of the two genes for EF-1 alpha from Saccharomyces cerevisiae.

1984 • 140 citations

Splicing of yeast nuclear pre-mRNA in vitro requires a functional 40S spliceosome and several extrinsic factors.

1987 • 137 citations

A point mutation in the conserved hexanucleotide at a yeast 5′ splice junction uncouples recognition, cleavage, and ligation

1985 • 129 citations

Mutations in elongation factor EF-1 alpha affect the frequency of frameshifting and amino acid misincorporation in Saccharomyces cerevisiae.

1988 • 125 citations

Position effects in ectopic and allelic mitotic recombination in Saccharomyces cerevisiae.

1989 • 123 citations

A quantitative analysis of the effects of 5′ junction and TACTAAC box mutants and mutant combinations on yeast mRNA splicing

1985 • 115 citations

RNA11 protein is associated with the yeast spliceosome and is localized in the periphery of the cell nucleus.

1988 • 102 citations

PRP4 (RNA4) from Saccharomyces cerevisiae: Its Gene Product Is Associated with the U4/U6 Small Nuclear Ribonucleoprotein Particle

1989 • 98 citations

[53] Isolation of genes by complementation in yeast

1987 • 95 citations

A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation.

1987 • 95 citations

Molecular Biology of Rna: New Perspectives

1988 • 91 citations

A RAPID CHROMOSOME-MAPPING METHOD FOR CLONED FRAGMENTS OF YEAST DNA

1983 • 87 citations

A Lysine Substitution in the ATP-Binding Site of Eucaryotic Initiation Factor 4A Abrogates Nucleotide-Binding Activity

1989 • 75 citations

Cloning of the RNA8 gene of Saccharomyces cerevisiae, detection of the RNA8 protein, and demonstration that it is essential for nuclear pre-mRNA splicing.

1988 • 72 citations

Mitotic gene conversion lengths, coconversion patterns, and the incidence of reciprocal recombination in a Saccharomyces cerevisiae plasmid system.

1986 • 70 citations

Architecture of Fungal Introns: Implications for Spliceosome Assembly

1987 • 59 citations

PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle.

1989 • 53 citations

A lysine substitution in the ATP-binding site of eucaryotic initiation factor 4A abrogates nucleotide-binding activity.

1989 • 47 citations

Effects on mRNA splicing of mutations in the 3' region of the Saccharomyces cerevisiae actin intron.

1987 • 43 citations

Isolation and characterization of the RNA2, RNA3, and RNA11 genes of Saccharomyces cerevisiae.

1984 • 42 citations

Transcriptional proofreading in Escherichia coli.

1989 • 41 citations

An elF-4A-like protein is a suppressor of an Escherichia coli mutant defective in 5OS ribosomal subunit assembly

1989 • 37 citations

[14] Use of transposon-promoted deletions in DNA sequence analysis

1987 • 31 citations

Isolation and characterization of the RNA2+, RNA4+, and RNA11+ genes of Saccharomyces cerevisiae

1984 • 31 citations

GTP and methionine bristles

1989 • 30 citations

Principles of protein structure

2018 • 30 citations

Cloning of the RNA2 gene of Saccharomyces cerevisiae.

1984 • 28 citations

Identifying domains in protein sequences.

1988 • 15 citations