C-C chemokines: novel mediators of the profibrotic inflammatory response to bleomycin challenge.

Transforming growth factor beta

2011 • 1,990 citations

Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family

1991 • 1,864 citations

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

Preferential Migration of Activated CD4 ⁺ and CD8 ⁺ T Cells in Response to MIP-1α and MIP-1β

1993 • 737 citations

Fibrogenic cytokines: the role of immune mediators in the development of scar tissue

1991 • 607 citations

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.

1989 • 578 citations

Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties.

1988 • 575 citations

Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.

1982 • 553 citations

Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes.

1993 • 530 citations

Monocyte chemoattractant protein-1 regulates adhesion molecule expression and cytokine production in human monocytes.

1992 • 509 citations

Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation.

1989 • 502 citations

Exaggerated Spontaneous Release of Platelet-Derived Growth Factor by Alveolar Macrophages from Patients with Idiopathic Pulmonary Fibrosis

1987 • 420 citations

Expression and generation of interleukin-8, IL-6 and granulocyte-macrophage colony-stimulating factor by bronchial epithelial cells and enhancement by IL-1 beta and tumour necrosis factor-alpha.

1992 • 355 citations

Regulation of neutrophil-derived chemokine expression by IL-10.

1994 • 347 citations

Hormonal Control of Immunoreactive Somatomedin Production by Cultured Human Fibroblasts

1981 • 323 citations

Lung Cytokine Production in Bleomycin-Induced Pulmonary Fibrosis

1992 • 321 citations

Macrophage inflammatory protein 1 modulates macrophage function.

1992 • 321 citations

Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin.

1979 • 306 citations

Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritis.

1994 • 304 citations

Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice

1994 • 287 citations

Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties.

1988 • 285 citations

Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells.

1985 • 257 citations

Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines.

1993 • 253 citations

Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia.

1995 • 248 citations

Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells

1989 • 247 citations

Platelet-derived growth factor and heparin-like glycosaminoglycans regulate thrombospondin synthesis and deposition in the matrix by smooth muscle cells.

1985 • 232 citations

The Biosynthesis of Collagen

1972 • 227 citations

Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica

1993 • 210 citations

Expression and regulation of human neutrophil-derived macrophage inflammatory protein 1 alpha.

1993 • 207 citations

Macrophage Inflammatory Proteins 1 and 2: Expression by Rat Alveolar Macrophages, Fibroblasts, and Epithelial Cells and in Rat Lung after Mineral Dust Exposure

1993 • 195 citations

Morphologic and biochemical study of pulmonary changes induced by bleomycin in mice.

1976 • 194 citations

Macrophage inflammatory protein-1 alpha activates basophils and mast cells.

1992 • 191 citations

Human eosinophils can express the cytokines tumor necrosis factor-alpha and macrophage inflammatory protein-1 alpha.

1993 • 188 citations

Induction of collagenase secretion in human fibroblast cultures by growth promoting factors.

1985 • 186 citations

The Role of Strain Variation in Murine Bleomycin-lnduced Pulmonary Fibrosis^1,2

1983 • 183 citations

Macrophage inflammatory protein-1 alpha expression in interstitial lung disease.

1993 • 180 citations

Alveolar type II epithelial cells produce interleukin-6 in vitro and in vivo. Regulation by alveolar macrophage secretory products.

1994 • 173 citations

The production of hydroxyl radical by bleomycin and iron (II)

1979 • 168 citations

Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis.

1994 • 164 citations

Production and function of murine macrophage inflammatory protein-1 alpha in bleomycin-induced lung injury.

1994 • 161 citations

The Effects of the Nude(nu/nu)Mutation on Bleomycin-induced Pulmonary Fibrosis

1983 • 145 citations

Biosynthesis and regulation of type V collagen in diploid human fibroblasts.

1983 • 142 citations

Platelet-derived growth factor promotes polymorphonuclear leukocyte activation

1984 • 132 citations

Modulation of JE/MCP-1 expression in dermal wound repair.

1995 • 130 citations

The role of macrophage inflammatory protein 1 alpha in Schistosoma mansoni egg-induced granulomatous inflammation.

1993 • 126 citations

Macrophage inflammatory protein-1 alpha and monocyte chemoattractant peptide-1 elicit immediate and late cutaneous reactions and activate murine mast cells in vivo.

1994 • 124 citations

Bi‐functional action of transforming growth factor‐β on DNA synthesis in early passage human fetal fibroblasts

1986 • 121 citations

Platelet-derived growth factor promotes human peripheral monocyte activation

1985 • 116 citations

The development of bleomycin-induced pulmonary fibrosis in neutrophil-depleted and complement-depleted rats.

1981 • 107 citations

Possible Mechanisms of Bleomycin-Induced Fibrosis

1990 • 106 citations

Differential cellular analysis of bronchoalveolar lavage fluid obtained at various stages during the development of bleomycin-induced pulmonary fibrosis in the rat.

1982 • 100 citations

Stimulation of rat endothelial cell transforming growth factor-beta production by bleomycin.

1991 • 98 citations

Transforming growth factor-beta and the glomerular extracellular matrix in renal pathology.

1994 • 96 citations

Production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 alpha by inflammatory granuloma fibroblasts.

1994 • 95 citations

Macrophage inflammatory protein‐1α influences eosinophil recruitment in antigen‐specific airway inflammation

1995 • 93 citations

SpontaneousIn VitroRelease of Alveolar-Macrophage Cytokines after the Intratracheal Instillation of Bleomycin in Rats: Characterization and Kinetic Studies

1988 • 86 citations

Effects of intratracheal administration of bleomycin on GSH-shuttle enzymes, catalase, lipid peroxidation, and collagen content in the lungs of hamsters

1983 • 85 citations

Platelet-Derived Growth Factor

1987 • 85 citations

Platelet-derived growth factor stimulates mouse 3T3 cell mitogenesis and leukocyte chemotaxis through different structural determinants.

1983 • 81 citations

Bleomycin-induced synthesis of type I procollagen by human lung and skin fibroblasts in culture

1980 • 78 citations

Stimulus and cell-specific expression of C-X-C and C-C chemokines by pulmonary stromal cell populations

1995 • 71 citations

A comparison of lymphocyte populations in lung tissue and in bronchoalveolar lavage fluid of rats at various times during the development of bleomycin-induced pulmonary fibrosis.

1984 • 68 citations

Potentiation of bleomycin-induced lung injury by exposure to 70% oxygen. Morphologic assessment.

1982 • 64 citations

Effect of Iron Deficiency on Bleomycin-induced Lung Fibrosis in the Hamster

1988 • 63 citations

Modulation of bleomycin-induced pulmonary fibrosis in the BALB/c mouse by cyclophosphamide-sensitive T cells.

1984 • 61 citations

Bleomycin-Induced Pulmonary Fibrosis in Genetically Mast Cell-Deficient WBB6F<sub>1</sub>-W/W<sup>v</sup> Mice and Mechanism of the Suppressive Effect of Tranilast, an Antiallergic Drug Inhibiting Mediator Release from Mast Cells, on Fibrosis

1991 • 54 citations

The Effect of Deferoxamine on Bleomycin-induced Lung Fibrosis in the Hamster

1985 • 53 citations

Secretion of Chemotaxins by Guinea Pig Lung Macrophages I. The Spectrum of Inflammatory Cell Responses

1980 • 50 citations

Genomic structure of murine macrophage inflammatory protein-1 alpha and conservation of potential regulatory sequences with a human homolog, LD78.

1991 • 48 citations

Potentiation of Bleomycin-induced Lung Injury by Exposure to 70% Oxygen

2015 • 44 citations

The Role of Macrophage-derived Chemoattractant Activities in the Early Inflammatory Events of Bleomycin-induced Pulmonary Injury^1–4

1983 • 43 citations

Enhanced release of a chemoattractant for alveolar macrophages after asbestos inhalation.

1983 • 42 citations

Changes in distribution, morphology, and tumor necrosis factor-alpha secretion of alveolar macrophage subpopulations during the development of bleomycin-induced pulmonary fibrosis.

1992 • 40 citations

Pulmonary fate of [3H]bleomycin A2 in mice.

1984 • 39 citations

Stimulatory effect of bleomycin on the synthesis of acidic glycosaminoglycans in cultured fibroblasts derived from rat carrageenin granuloma

1976 • 39 citations

Evidence for free radical involvement in the hydroxylation of proline: Inhibition by nitro blue tetrazolium

1972 • 37 citations

Changes in Plasma Concentrations of Prostaglandins and Plasma Angiotensin-Converting Enzyme during Bleomycin-induced Lung Fibrosis in Hamsters^1–3

1983 • 37 citations

Immunohistochemical demonstration of interleukin-1 receptor antagonist protein and interleukin-1 in human lymphoid tissue and granulomas.

1992 • 36 citations

Protective Effect of Hypoxia on Bleomycin Lung Toxicity in the Rat

1984 • 35 citations

Secretion of monocyte chemotactic activity by alveolar macrophages.

1989 • 35 citations

Transforming growth factor-β1 inhibits activation of macrophage cell line RAW 264.7 for cell killing

1990 • 34 citations

Induction, characterization, and functional coupling of the high affinity chemokine receptor for RANTES and macrophage inflammatory protein-1 alpha upon differentiation of an eosinophilic HL-60 cell line.

1994 • 32 citations

Deferoxamine injection does not affect bleomycin-induced lung fibrosis in rats.

1985 • 32 citations

The effect of prostaglandin E2 (PGE2) on amino acid uptake and protein formation by lung fibroblasts.

1986 • 25 citations

Regulation of Rat Pulmonary Endothelial Cell Interleukin-6 Production by Bleomycin: Effects of Cellular Fatty Acid Composition

1993 • 18 citations

Effects of bleomycin on ¹⁴C‐proline uptake, its incorporation into proteins and hydroxylation in collagenous proteins of hamster lung slices

1985 • 13 citations

Effects of Intratracheal Administration of Bleomycin on Prostaglandins and Thromboxane-B₂and Collagen Levels of the Lung in Hamsters

1985 • 12 citations

Rat macrophage activation after treatment with the bleomycin group of antitumour antibiotics in vivo

1992 • 11 citations

Influence of 6-keto-PGF1α on collagen synthesis in the human cervix during various phases of the menstrual cycle

1981 • 11 citations

Expression of monocyte chemotactic and activating factor (MCAF) in skin related cells. A comparative study

1993 • 11 citations

[Interstitial pulmonary fibrosis].

1970 • 9 citations

Continuous secretion of monocyte chemotactic factors and fibroblast growth factors by alveolar macrophages following a single exposure to bleomycin in vitro.

1992 • 7 citations

Deleted Work

1955 • 0 citations