Changes in distribution, morphology, and tumor necrosis factor-alpha secretion of alveolar macrophage subpopulations during the development of bleomycin-induced pulmonary fibrosis.

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.

1989 • 578 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Production of fibronectin by the human alveolar macrophage: mechanism for the recruitment of fibroblasts to sites of tissue injury in interstitial lung diseases.

1981 • 344 citations

Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages

1986 • 344 citations

The Pulmonary-Alveolar Macrophage

1979 • 331 citations

Bronchoalveolar Lavage in Interstitial Lung Disease

1978 • 302 citations

Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production.

1980 • 282 citations

Human Alveolar Macrophage-derived Chemotactic Factor for Neutrophils

1980 • 253 citations

Immunologic Abnormalities in Sarcoidosis

1980 • 244 citations

Characterization of the inflammatory and immune effector cells in the lung parenchyma of patients with interstitial lung disease.

1981 • 233 citations

Specific assays for cytokine production by T cells

1989 • 228 citations

Mechanisms of pulmonary fibrosis. Spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders.

1983 • 217 citations

Characterization of mononuclear phagocyte subpopulations in the human lung by using monoclonal antibodies: changes in alveolar macrophage phenotype associated with pulmonary sarcoidosis.

1985 • 163 citations

Morphometric estimates of infiltrative cellular changes during the development of bleomycin-induced pulmonary fibrosis in hamsters.

1983 • 144 citations

Lymphocyte modulation of fibroblast function in vitro: stimulation and inhibition of collagen production by different effector molecules.

1984 • 139 citations

The Pulmonary-Alveolar Macrophage

1979 • 134 citations

Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin: pathology and stereology.

1978 • 132 citations

Human alveolar macrophage inhibition of lung fibroblast growth. A prostaglandin-dependent process.

1985 • 110 citations

Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin. Lung volumes, volume-pressure relations, carbon monoxide uptake, and arterial blood gas studied.

1978 • 107 citations

Differential cellular analysis of bronchoalveolar lavage fluid obtained at various stages during the development of bleomycin-induced pulmonary fibrosis in the rat.

1982 • 100 citations

Tumor Necrosis Factor Interacts with Interleukin-1 and Interferons to Inhibit Fibroblast Proliferation via Fibroblast Prostaglandin-dependent and -independent Mechanisms

1988 • 96 citations

Bleomycin-induced pulmonary fibrosis in hamsters. An alveolar macrophage product increases fibroblast prostaglandin E2 and cyclic adenosine monophosphate and suppresses fibroblast proliferation and collagen production.

1983 • 79 citations

Inhibition of bleomycin-induced pulmonary fibrosis by nordihydroguaiaretic acid. The role of alveolar macrophage activation and mediator production.

1986 • 64 citations

Secretion of Macrophage-Derived Growth Factor During Acute Lung Injury Induced by Bleomycin

1985 • 60 citations

Human Alveolar Macrophage and Blood Monocyte Inhibition of Fibroblast Proliferation: Evidence for Synergy between Interleukin-1 and Tumor Necrosis Factor

1988 • 48 citations

Prostaglandin synthesis and release by subpopulations of rat alveolar macrophages.

1987 • 47 citations

The Role of Macrophage-derived Chemoattractant Activities in the Early Inflammatory Events of Bleomycin-induced Pulmonary Injury^1–4

1983 • 43 citations

Fractionation of Rat Alveolar Macrophages by Isopycnic Centrifugation: Morphological, Cytochemical, Biochemical, and Functional Properties

1986 • 39 citations

Changes in Plasma Concentrations of Prostaglandins and Plasma Angiotensin-Converting Enzyme during Bleomycin-induced Lung Fibrosis in Hamsters^1–3

1983 • 37 citations

Expression of Ia-like (DR) antigen on human alveolar macrophages isolated by bronchoalveolar lavage.

1984 • 36 citations

Modulation of the effects of alveolar macrophages on lung fibroblast collagen production rate.

1987 • 31 citations

Studies of membrane receptors and phagocytosis in subpopulations of rat alveolar macrophages.

1986 • 29 citations

Enhanced fibroblast collagen production by a macrophage-derived factor (CEMF)

1982 • 24 citations

Human monocyte modulation of endothelial cells and fibroblast growth: Possible mechanism for fibrosis

1986 • 24 citations

Alterations in Alveolar Macrophages in Hamsters Developing Pulmonary Fibrosis

1984 • 15 citations

[Bronchoalveolar lavage in interstitial lung diseases].

1987 • 12 citations

Studies on Bronchoalveolar Cells in Humans

1978 • 11 citations