The Biosynthesis of Collagen

CROSS-LINKING IN COLLAGEN AND ELASTIN

1984 • 1,267 citations

The Chromatographic Separation and Amino Acid Composition of the Subunits of Several Collagens^*

1963 • 706 citations

Studies of muscle capillary basement membranes in normal subjects, diabetic, and prediabetic patients

1968 • 598 citations

The acid mucopolysaccharides of connective tissue

1956 • 584 citations

On the biological role of glycoproteins

1966 • 443 citations

The Structure Of Collagen And Gelatin

1962 • 391 citations

The Chemistry and Reactivity of Collagen

1956 • 387 citations

An autoradiographic and electron microscopic study of collagen synthesis in differentiating cartilage

1963 • 367 citations

Cross-linking of collagen and elastin. Properties of lysyl oxidase

1970 • 342 citations

The Structure of the Disaccharide Unit of the Renal Glomerular Basement Membrane

1967 • 333 citations

CHICK CARTILAGE COLLAGEN: A NEW TYPE OF α1 CHAIN NOT PRESENT IN BONE OR SKIN OF THE SPECIES

1969 • 329 citations

BIOLOGICAL FUNCTIONS OF COLLAGEN

1961 • 309 citations

Cofactor and substrate requirements of collagen proline hydroxylase

1967 • 300 citations

Evidence for the Linkage of a Disaccharide to Hydroxylysine in Tropocollagen

1966 • 298 citations

WOUND HEALING AND COLLAGEN FORMATION

1965 • 298 citations

Characterization and Quantitative Determination of the Hydroxylysine-linked Carbohydrate Units of Several Collagens

1969 • 289 citations

Degradation Products from Elastin: Partial Structure of Two Major Degradation Products from the Cross-linkages in Elastin

1963 • 288 citations

A SUBUNIT MODEL FOR THE TROPOCOLLAGEN MACROMOLECULE

1964 • 284 citations

Synthesis and extrusion of collagen by freshly isolated cells from chick embryo tendon

1971 • 280 citations

SOME ASPECTS OF THE METABOLISM OF HYDROXYPROLINE, STUDIED WITH THE AID OF ISOTOPIC NITROGEN

1949 • 277 citations

Synthesis and Transfer of Amylase in Pigeon Pancreatic Microsomes

1966 • 272 citations

Action of Proteolytic Enzymes on Tropocollagen and Insoluble Collagen^*

1966 • 258 citations

THE DETERMINATION OF COLLAGEN AND ELASTIN IN TISSUES, WITH RESULTS OBTAINED IN VARIOUS NORMAL TISSUES FROM DIFFERENT SPECIES

1941 • 256 citations

The Determination of Collagen and Elastin

1967 • 250 citations

Purification and partial characterization of a soluble elastin-like protein from copper-deficient procine aorta

1969 • 238 citations

The Nature of the Collagen Synthesized by Cultured Human Fibroblasts

1971 • 238 citations

The formation of fibrils from collagen solutions. 3. Effect of chondroitin sulphate and some other naturally occurring polyanions on the rate of formation

1960 • 237 citations

Connective tissue growth stimulated by carrageenin. 1. The formation and removal of collagen

1957 • 228 citations

The metabolism of collagen from liver, bone, skin and tendon in the normal rat

1953 • 213 citations

Bausteinanalysen von humanserumproteinen

1964 • 197 citations

Evidence for Procollagen, a Biosynthetic Precursor of Collagen

1971 • 193 citations

Isolation of two distinct collagens from chick cartilage

1970 • 193 citations

Glycoproteins: Their Biochemistry, Biology and Role in Human Disease

1969 • 193 citations

Collagen Cross-linking

1970 • 193 citations

Chemistry of the collagen cross-links. Isolation and characterization of two intermediate intermolecular cross-links in collagen

1970 • 189 citations

Collagen Proline Hydroxylase in Wound Healing, Granuloma Formation, Scurvy, and Growth

1967 • 185 citations

ENZYMATIC HYDROXYLATION OF PROLINE IN MICROSOMAL POLYPEPTIDE LEADING TO FORMATION OF COLLAGEN

1965 • 184 citations

Hydroxylation of Proline and the Intracellular Accumulation of a Polypeptide Precursor of Collagen

1966 • 180 citations

Conversion of Proline to Collagen Hydroxyproline in a Cell-free System from Chick Embryo

1963 • 180 citations

Resting transmembrane potential difference of skeletal muscle in normal subjects and severely ill patients

1971 • 179 citations

A Defect in the Intramolecular and Intermolecular Cross-linking of Collagen Caused by Penicillamine

1969 • 177 citations

Human Glomerular Basement Membrane: Chemical Alteration in Diabetes Mellitus

1970 • 176 citations

The Structure of Human Hemoglobin

1962 • 176 citations

THE METABOLISM OF l(-)-PROLINE STUDIED WITH THE AID OF DEUTERIUM AND ISOTOPIC NITROGEN

1944 • 176 citations

Structural components of epithelial and endothelial basement membranes

1969 • 174 citations

ENZYMATIC HYDROXYLATION OF PROLINE AND LYSINE IN PROTOCOLLAGEN

1967 • 171 citations

Collagen and Cell Protein Synthesis by an Established Mammalian Fibroblast Line

1964 • 169 citations

Hydroxylation of Proline in Synthetic Polypeptides with Purified Protocollagen Hydroxylase

1967 • 167 citations

Aging of the Collagen Fiber

1964 • 167 citations

IMMUNOGLOBULIN SYNTHESIS AND SECRETION

1970 • 163 citations

EFFECT OF PENICILLAMINE ON HUMAN COLLAGEN AND ITS POSSIBLE APPLICATION TO TREATMENT OF SCLERODERMA

1966 • 158 citations

Isolation and characterization of the collagen from glomerular basement membrane

1968 • 152 citations

Isotopic Studies on Collagen Degradation and the Urine Excretion of Hydroxyproline *

1964 • 152 citations

Purification and properties of collagen proline hydroxylase from newborn rat skin

1970 • 152 citations

Comparative Sequence Studies of Rat Skin and Tendon Collagen. I. Evidence for Incomplete Hydroxylation of Individual Prolyl Residues in the Normal Proteins^*

1967 • 149 citations

Isotopic Studies on Urinary Hydroxyproline as Evidence for Rapidly Catabolized Forms of Collagen in the Young Rat

1961 • 148 citations

Structure of α1-CB8, a large cyanogen bromide produced fragment from the α1 chain of rat collagen. The nature of a hydroxylamine-sensitive bond and composition of tryptic peptides

1970 • 146 citations

Isolation and characterization of the cyanogen bromide peptides from the .alpha.1(II) chain of chick cartilage collagen

1971 • 145 citations

The Separation and Characterization of the α- and β-Components of Calf Skin Collagen

1960 • 142 citations

Further evidence for a transport form of collagen. Its extrusion and extracellular conversion to tropocollagen in embryonic tendon

1971 • 135 citations

Biosynthesis of abnormal collagens with amino acid analogues

1969 • 134 citations

Glycoprotein biosynthesis: The localization of polypeptidyl: N-acetylgalactosaminyl, collagen: Glucosyl, and glycoprotein: Galactosyl transferases in HeLa cell membrane fractions

1968 • 133 citations

The effect of penicillamine on the laboratory parameters in rheumatoid arthritis

1965 • 130 citations

SYNTHESIS OF HYDROXYPROLINE IN VITRO BY THE HYDROXYLATION OF PROLINE IN A PRECURSOR OF COLLAGEN

1965 • 130 citations

Hydroxylation of proline residues in collagen nascent chains

1970 • 129 citations

Studies on the Biosynthesis of the Hydroxylysine-linked Disaccharide Unit of Basement Membranes and Collagens

1971 • 127 citations

Decarboxylation of alpha-ketoglutarate coupled to collagen proline hydroxylase.

1968 • 127 citations

COLLAGEN PROFILE IN VARIOUS CLINICAL CONDITIONS

1966 • 122 citations

Influence of chelating agents on the biosynthesis of collagen

1965 • 119 citations

Incorporation of 18O from air into hydroxyproline by chick embryo

1962 • 113 citations

Electron microscope studies of the effects of endo- and exopeptidase digestion on tropocollagen

1970 • 108 citations

The Formation of Triple‐Helical Collagen Molecules from α1 or α2 Polypeptide Chains

1969 • 108 citations

Purification and partial characterization of the enzyme for the hydroxylation of proline in protocollagen

1967 • 106 citations

On the Molecular Structure of Collagen

1969 • 105 citations

Incorporation of Labelled Lysine into the Desmosine Cross-bridges in Elastin

1966 • 105 citations

Protocollagen Proline Hydroxylase in Normal Liver and in Hepatic Fibrosis

1969 • 105 citations

Protocollagen Proline Hydroxylase Activity in the Skin of Normal Human Subjects and of Patients with Scleroderma

1969 • 103 citations

A Comparative Study of Glycopeptides Derived from Selected Vertebrate Collagens

1970 • 101 citations

The utilization of lysine in the biosynthesis of elastin crosslinks

1964 • 100 citations

Purification and amino acid composition of monomeric and polymeric collagens

1967 • 96 citations

Collagen chain formation and peptidyl proline hydroxylation in monolayer tissue cultures of L-929 fibroblasts

1969 • 95 citations

Isolation and partial characterization of highly purified protocollagen proline hydroxylase

1970 • 93 citations

Intermolecular Cross-links in Reconstituted Collagen Fibrils

1968 • 93 citations

Cofactor requirements for the enzymatic hydroxylation of lysine in a polypeptide precursor of collagen

1967 • 93 citations

Studies on the Biosynthesis of the Hydroxylysine-linked Disaccharide Unit of Basement Membranes and Collagens

1971 • 92 citations

Attachment of carbohydrate to collagen. Isolation, purification and properties of the glucosyl transferase

1968 • 92 citations

Incorporation of cis-Hydroxyproline into Protocollagen and Collagen

1971 • 91 citations

Biochemistry of collagen crosslinking isolation of a new crosslink, hydroxylysinohydroxynorleucine, and its reduced precursor, dihydroxynorleucine, from bovine tendon

1970 • 88 citations

Effect of Lactate on Collagen Proline Hydroxylase Activity in Cultured L-929 Fibroblasts

1970 • 87 citations

Proposed Mechanism for the Biological Assembly of Collagen Triple Helix

1971 • 85 citations

Collagen synthesis on polyribosomes of cultured mammalian fibroblasts

1967 • 84 citations

Chemical studies on the cyanogen bromide peptides of rat skin collagen. Covalent structure of α1-CB5, the major hexose-containing cyanogen bromide peptide of α1

1970 • 80 citations

Fibrinogen to Fibrin Transformation

1967 • 80 citations

Incorporation of cis- and trans-4-Fluoro-L-prolines into Proteins and Hydroxylation of the trans Isomer During Collagen Biosynthesis^*

1965 • 79 citations

THE CONVERSION OF LYSINE TO HYDROXYLYSINE AND ITS RELATION TO THE BIOSYNTHESIS OF COLLAGEN IN SEVERAL TISSUES OF THE RAT

1957 • 79 citations

Oxygen-18 studies on the conversion of proline to collagen hydroxyproline

1963 • 79 citations

The compositio of bovine cartilage and bone

1967 • 77 citations

Incorporation of 3,4-Dehydroproline into Protocollagen and Collagen

1970 • 77 citations

Dissociation of the synthesis of sulphated mucopolysaccharides and the synthesis of collagen in embryonic cartilage

1966 • 77 citations

Protocollagen proline hydroxylase activity in experimental pulmonary fibrosis of rats.

1970 • 76 citations

INTRACELLULAR ACCUMULATION OF PROTOCOLLAGEN AND EXTRUSION OF COLLAGEN BY EMBRYONIC CARTILAGE CELLS

1968 • 75 citations

THE SOURCE AND STATE OF THE HYDROXYLYSINE OF COLLAGEN

1955 • 75 citations

Synthetic polypeptides as substrates and inhibitors of collagen proline hydroxylase

1968 • 75 citations

Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo I. Arrest of collagen accumulation in growing chick embryos

1971 • 75 citations

Synthesis of Collagen on Polyribosomes

1964 • 74 citations

H³‐proline incorporation into cartilage: Electron microscope autoradiographic observations

1968 • 74 citations

Sedimentation-Equilibrium Studies of the Molecular Weight of Single and Double Chains from Rat-Skin Collagen

1964 • 74 citations

Amino acid sequence of cyanogen bromide peptides from the amino-terminal region of chick skin collagen

1970 • 72 citations

Biosynthesis of abnormal collagens with amino acid analogues. II. Inability of cartilage cells to extrude collagen polypeptides containing L-azetidine-2-carboxylic acid or cis-4-fluoro-L-proline.

1969 • 70 citations

Studies in vivo on the biosynthesis of collagen and elastin in ascorbic acid-deficient guinea pigs. Evidence for the formation and degradation of a partially hydroxylated collagen

1970 • 68 citations

Studies on beta‐aminopropionitrile in patients with scleroderma

1967 • 68 citations

Glycoprotein biosynthesis: The biosynthesis of the hydroxylysine-galactose linkage in collagen

1968 • 68 citations

Inhibition of proline and lysine hydroxylation prevents normal extrusion of collagen by 3T6 fibroblasts in culture

1971 • 67 citations

Partial characterization of protocollagen from embryonic cartilage

1967 • 67 citations

Collagen polysomes: Site of hydroxylation of proline residues

1971 • 66 citations

The Source and State of the Hydroxylysine of Collagen

1959 • 66 citations

PROLINE-HYDROXYLASE ACTIVITY IN HUMAN BLOOD

1970 • 65 citations

Direct evidence for a correlation between amino acid sequence and cross striation pattern of collagen

1970 • 63 citations

Kinetic patterns of protocollagen hydroxylase and further studies on the polypeptide substrate

1968 • 62 citations

Biosynthesis of abnormal collagens with amino acid analogues

1969 • 61 citations

Experimental Lathyrism

1965 • 60 citations

Formation of Enzyme-Substrate Complexes with Protocollagen Proline Hydroxylase and Large Polypeptide Substrates

1969 • 59 citations

Collagen metabolism of the skin in Marfan's syndrome

1968 • 57 citations

Biosynthesis of the α Chains of Collagen Studied by Pulse-labeling in Culture

1970 • 56 citations

Polymers of tripeptides as collagen models

1969 • 56 citations

Elevation of Aortic Proline Hydroxylase: A Biochemical Defect in Experimental Arteriosclerosis

1970 • 54 citations

Variations in the carbohydrate content of human and bovine polymeric collagens from various tissues

1969 • 53 citations

Hydroxylation of lysine in a polypeptide precursor of collagen

1966 • 52 citations

Partial Hydroxylation of Certain Lysines In Collagen

1968 • 51 citations

Connective Tissue: I. Age and Sex Influence on Protein Composition of Rat Tissues

1959 • 48 citations

Mucopolysaccharides and mucoproteins of calf scapula

1967 • 46 citations

Calcium, Cholesterol, and Collagen Levels in Human Aortas

1960 • 46 citations

Hydroxylation of proline in particulate fractions from cartilage

1965 • 46 citations

The cross-linking of collagen and elastin and its inhibition in osteolathyrism

1970 • 45 citations

The sulfhydryl nature of collagen proline hydroxylase

1969 • 44 citations

The Incomplete Hydroxylation of Individual Prolyl Residues in Collagen

1967 • 43 citations

α-Ketoglutarate and hydroxylation of γ-butyrobetaine

1968 • 41 citations

BIOSYNTHESIS OF COLLAGEN

1967 • 41 citations

The structure of collagen.

1969 • 41 citations

Penicillamine for Scleroderma

1968 • 41 citations

Oligopeptides with the Sequences Ala-Pro-Gly and Gly-Pro-Gly as Substrates or Inhibitors for Protocollagen Proline Hydroxylase

1969 • 40 citations

Effect of Polymer Size on the Inhibition of Protocollagen Proline Hydroxylase by Polyproline II

1969 • 39 citations

The size of the polypeptide precursor of collagen hydroxyproline.

1966 • 39 citations

Carbohydrate content of bovine collagen preparations

1968 • 39 citations

Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo II. Morphological and physical properties of collagen containing the analogue

1971 • 39 citations

Hydroxylation of proline and lysine in protocollagen involves two separate enzymatic sites

1969 • 38 citations

Solubility of skin collagen in normal human subjects and in patients with generalised scleroderma

1971 • 38 citations

The polyribosomal synthesis of collagen

1967 • 36 citations

HOMOCYSTINURIA

1969 • 35 citations

Basicity differences among peptide bonds

1970 • 34 citations

Relationship between the Intra and Inter molecular Cross-links of Collagen

1970 • 33 citations

Increased protocollagen proline hydroxylase activity in synovial tissue in rheumatoid arthritis

1970 • 30 citations

Carbohydrate content of insoluble elastins prepared from adult bovine and calf ligamentum nuchae and tropoelastin isolated from copper-deficient procine aorta

1971 • 29 citations

The Physiology of Connective Tissue

1955 • 28 citations

Biosynthesis of the Intramolecular Cross-links in Rat Skin Collagen

1968 • 27 citations

Capillary basement membrane structure: a comparative study of diabetics and sexual ateliotic dwarfs

1970 • 27 citations

Spontaneous generation of cross-links in aldehyde-containing collagen

1970 • 26 citations

Inhibition of collagen hydroxylysine formation by chelating agents

1967 • 24 citations

Untersuchungen zur Chemie der Arterienwand, I. Quantitative Zusammensetzung des Gefäßbindegewebes

1958 • 22 citations

HERITABLE DISORDERS OF CONNECTIVE TISSUE: Third Edition

1966 • 22 citations

Ocular fine structure : selected electron micrographs

1964 • 21 citations

The absence of iron and certain coenzymes in highly purified protocollagen proline hydroxylase

1971 • 19 citations

Electron Microscopy of Protocollagen Proline Hydroxylase from Chick Embryos

1970 • 18 citations

Hydroxyprolyl-soluble ribonucleic acid and the biosynthesis of collagen

1966 • 15 citations

The intracellular biosynthesis of collagen. Some possible implications for diseases of bone and other connective tissues

1969 • 15 citations

Biochemistry of experimental lathyrism

1961 • 14 citations

Age and the Fibrous Proteins of the Human Lung

1961 • 13 citations

A textbook of biochemistry

1946 • 13 citations

Site of proline hydroxylation during collagen synthesis in mouse fibroblasts

1970 • 12 citations

Collagen biosynthesis. A review.

1970 • 11 citations

In vitro Incorporation and Hydroxylation of Lysine-2-C14 In Rat Biopsy-Connective Tissue.

1958 • 9 citations

CELLULAR SYNTHESIS OF COLLAGEN: RIBOSOMAL AGGREGATES IN HYPERTHYROIDISM, HYPOTHYROIDISM, AND ASCORBIC ACID DEPLETION.

1965 • 8 citations

Collagen Fractions in the Skin of New-Born and Adult Rats

1961 • 4 citations