Review: Potential of renin inhibition in cardiovascular disease

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

2000 • 8,612 citations

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

1999 • 8,588 citations

Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure

1991 • 8,296 citations

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 • 7,165 citations

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

2001 • 5,812 citations

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

2002 • 5,471 citations

Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack

2001 • 3,093 citations

A Randomized Trial of the Angiotensin-Receptor Blocker Valsartan in Chronic Heart Failure

2001 • 3,065 citations

Global Burden of Cardiovascular Diseases

2001 • 2,932 citations

A Randomized Trial of Propranolol in Patients With Acute Myocardial Infarction

1982 • 1,286 citations

Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial

2002 • 1,190 citations

Essential Hypertension: Renin and Aldosterone, Heart Attack and Stroke

1972 • 1,098 citations

The Renin-Angiotensin System

1978 • 969 citations

Niere und Kreislauf¹

1898 • 761 citations

Tissue Angiotensin and Pathobiology of Vascular Disease

2001 • 750 citations

Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

2002 • 545 citations

Angiotensin II Type 1 Receptor Blockers

2001 • 477 citations

Renal protective effect of enalapril in diabetic nephropathy.

1992 • 437 citations

Effect of Angiotensin-Converting Enzyme Inhibitors on the Progression of Nondiabetic Renal Disease

1997 • 436 citations

A CRYSTALLINE PRESSOR SUBSTANCE (ANGIOTONIN) RESULTING FROM THE REACTION BETWEEN RENIN AND RENIN-ACTIVATOR

1940 • 427 citations

Angiotensin II Suppression in Humans by the Orally Active Renin Inhibitor Aliskiren (SPP100)

2002 • 409 citations

Angiotensin-(1-7) Dilates Canine Coronary Arteries Through Kinins and Nitric Oxide

1996 • 401 citations

Levels of angiotensin and molecular biology of the tissue renin angiotensin systems

1993 • 333 citations

Angiotensin-(1–7) Attenuates the Development of Heart Failure After Myocardial Infarction in Rats

2002 • 323 citations

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

2000 • 310 citations

The Renin-Angiotensin System

1974 • 307 citations

Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV.

1995 • 303 citations

Angiotensin-(1-7) Inhibits Vascular Smooth Muscle Cell Growth

1996 • 294 citations

Metabolism of Angiotensin-(1–7) by Angiotensin-Converting Enzyme

1998 • 290 citations

Discovery of a distinct binding site for angiotensin II (3–8), a putative angiotensin IV receptor

1992 • 265 citations

Functional and Biochemical Analysis of Angiotensin II–Forming Pathways in the Human Heart

1997 • 246 citations

Angiotensin-(1–7) Augments Bradykinin-Induced Vasodilation by Competing With ACE and Releasing Nitric Oxide

1997 • 245 citations

Effects of captopril related to increased levels of prostacyclin and angiotensin-(1-7) in essential hypertension

1996 • 229 citations

Vasodepressor Actions of Angiotensin-(1–7) Unmasked During Combined Treatment With Lisinopril and Losartan

1998 • 228 citations

From the hope to the ontarget and the transcend studies: challenges in improving prognosis

2002 • 171 citations

Natriuretic action of angiotensin(1–7)

1994 • 155 citations

Contrasting effects of enalapril and metoprolol on proteinuria in diabetic nephropathy.

1990 • 131 citations

Renin inhibition by substituted piperidines: A novel paradigm for the inhibition of monomeric aspartic proteinases?

1999 • 124 citations

Canine Ventricular Myocytes Possess a Renin-Angiotensin System That Is Upregulated With Heart Failure

2001 • 115 citations

Angiotensin (1???7) is an antagonist at the type 1 angiotensin II receptor

1994 • 108 citations

Specific inhibition of renin by an angiotensinogen analog: studies in sodium depletion and renin-dependent hypertension.

1980 • 100 citations

Responses to converting enzyme and renin inhibition. Role of angiotensin II in humans.

1994 • 78 citations

The Nature of Intracrine Peptide Hormone Action

1999 • 78 citations

Is there a future for renin inhibitors?

2001 • 69 citations

Renal Circulation and Blockade of the Renin-Angiotensin System

1995 • 62 citations

Effects of Blocking the Angiotensin II Receptor, Converting Enzyme, and Renin Activity on the Renal Hemodynamics of Normotensive Guinea Pigs

1993 • 45 citations

Effects of an Orally Active Renin Inhibitor, Ro 42-5892, in Patients With Essential Hypertension

1993 • 41 citations

Assessment of renin dependency of hypertension with a dipeptide renin inhibitor.

1990 • 41 citations

Immediate blood pressure effects of the renin inhibitor enalkiren and the angiotensin-converting enzyme inhibitor enalaprilat

1991 • 39 citations

La sustancia hypertensora de la sangre del rinon isquemiado

1939 • 26 citations

Comparison of blood pressure and angiotensin responses to the renin inhibitor Ro 42-5892 and the angiotensin converting enzyme inhibitor enalapril in essential hypertension

1993 • 24 citations

Dose response antihypertensive efficacy of aliskiren (SPP 100), an orally active renin inhibitor

2002 • 9 citations